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T Niijima

Publications and source records attributed to T Niijima.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Antiemetic effects of MS-5080 associated with cisplatin chemotherapy--an attempt in assessment based on the sample score system using multivariate analysis].

Effect of a new antiemetic drug, MS-5080 was evaluated against nausea and vomiting induced by chemotherapy including cisplatin. Fifty patients with various urological malignancies were registered into this study, which were distributed to the aliquot number with a respective dose schedule of 2, 3, 4 and 5 mg/kg body weight of MS-5080. Forty-seven patients with a total of 73 chemotherapeutic courses were eligible for evaluation of antiemetic efficacy, whereas the side effect of MS-5080 were evaluated in 48 patients with a total of 74 courses. Antiemetic efficacy was evaluated in terms of duration of nausea, duration of vomiting, duration of food intolerance, and the number of vomiting episodes. No statistically significant difference was observed in relation to the dose dependency of MS-5080. In assessment of the side effects, a relatively high incidence of diarrhea was observed compared to the other known antiemetic drugs. In the present study, we attempted an evaluation based on the sample score system using multivariate analysis. The results were correlated well with results of a grading system of efficacy that were determined by each physician who treated the patients.

Adult↗
PubMed1986

Phase II study of alpha interferon on renal cell carcinoma. Summary of three collaborative trials.

A cooperative study was carried out in 44 institutions in Japan to evaluate the clinical efficacy of two kinds of recombinant human leukocyte interferon (Ro 22-8181 and Sch 30500) and a human lymphoblastoid interferon (MOR-22) on metastatic lesions of renal cell carcinoma. Of 226 evaluable cases, efficacy was observed in 40 cases; complete response (CR) in 4 cases, and partial response (PR) in 36 cases, indicating an overall response rate of 17.7%. Although there were no statistically significant differences in age range, sex distribution, and performance status between responders and nonresponders, the incidence of poor response was significantly higher among patients in whom primary renal cell carcinoma had remained or in those who had prior chemotherapy and/or radiation therapy. When response was assessed with regard to individual metastatic sites of renal cell carcinoma, pulmonary metastasis was significantly susceptible to interferon treatment, compared to other metastatic sites. The median period to achieve CR or PR was 45 days (range, 22-211 days) and the median length to maintain CR or PR was 79 days (range, 29-278 days). The median of pulmonary metastatic area that was measured by the sum of the products of the largest perpendicular diameters was 7.2 cm2 (0.5-107.8 cm2), which was reduced to 1.1 cm2 (0-48.8 cm2) by alpha interferons. Cumulative survival of all responder patients was significantly longer than that of other patients with poor response.

Adenocarcinoma↗
PubMed1986

Mutual neoplastic promotion by instillation of mitomycin C and cauterization on rat bladder urothelium.

The authors studied the effect of bladder instillation of mitomycin C (MMC), a potential carcinogen, on the duration and severity of the hyperplasia induced by transurethral fulguration. This experimental system may simulate closely the intravesical chemoprophylaxis of MMC after transurethral resection of bladder cancer. Physiologic saline or MMC was instilled into the rat bladder once on the day of, or 3 or 7 days after cauterization. In all groups instilled with physiologic saline the changes were reversed by day 14. On the other hand, five of nine MMC-instilled rats developed papillary lesions, and three of these had mild dysplastic epithelium on day 84. Under the scanning electron microscope, the animals of these groups showed pleomorphic microvilli on the luminal surface of the regenerative cells on days 10 and 14 after cauterization. These results may indicate the mutual neoplastic promotion by instillation of MMC and cauterization to a certain extent.

Animals↗
PubMed1986

Quantitative analysis of ultrasonogram of the prostate.

In 51 cases with prostatic cancer, 88 with prostatic hypertrophy, 109 with prostatitis, and 174 normal subjects, the following five parameters were calculated from prostatic ultrasonograms scanned transrectally; prostatic weight (W), presumed circle area ratio (PCAR), anteroposterior diameter/transverse diameter (ATR), asymmetry index (ASI), and dissimilarity index (DSI). The W and PCAR were higher in cancer and hypertrophy than in prostatitis and normal subjects. The ATR and ASI were higher in cancer. The DSI was lower in hypertrophy. A canonical discriminant analysis using these five parameters disclosed two canonical variates that were useful to separate the disease entities: one separated cancer and hypertrophy from prostatitis and normal subjects, and the other separated cancer from hypertrophy. The coefficients of these variates indicated that cancer was separated from prostatitis and normal subjects by increases in W and ATR and from hypertrophy by the greater effect of increases in ATR (as compared to PCAR) and the small increases in W.

Biometry↗
PubMed1986

Species differences in regenerative hyperplasia of bladder urothelium after transurethral cauterization.

The early histological changes in bladder urothelium following transurethral cauterization were sequentially studied in female rats, mice, hamsters and guinea pigs. The changes differed markedly between species: papillary hyperplasia or papilloma in the rats and simple hyperplasia in the mice, hamsters and guinea pigs. The regenerative response to the fulgurative ulcer within a given species was similar to the early response previously observed by others following administration of known bladder carcinogens. This suggests that there may be a regulatory mechanism in the urothelium which is common to urothelial proliferations induced by both carcinogenic and non-carcinogenic stimulations, though differing between animal species.

Animals↗
PubMed1986

[Surgery and adjuvant chemotherapy of disseminated testicular cancer].

The advent of combination chemotherapy regimens including Cis-Platinum (CDDP) in the 1970s brought about revolutionary improvement of short-term as well as long-term results of disseminated testicular cancer. PVB therapy (CDDP, Vinblastine and Bleomycin) introduced by L.H. Einhorn is reported to yield a 100% response rate but in Japan combination chemotherapy incorporating CDDP has not produced its maximal effects according to our results as well as analyses carried out by a multi-center cooperative study group. This is probably due to the toxicities and side effects of the drugs used. Facilities to deal with the high toxicities, i.e., severe myelosuppression, as well as enthusiasm on the part of the physician determined to arrive at a complete cure in each patient are prerequisite for the achievement of this final goal.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Effects of etretinate on spermatogenesis and endocrine parameter function in man].

Nine adult men with psoriasis were treated orally with 50-75 mg/day aromatic retinoid, etretinate for more than 3 months. Semen analyses as well as measurement of serum levels of LH, FSH, prolactin, testosterone and estradiol were performed before and every month during the therapy for 3 months or more in order to study the effects of the drug on male reproductive function. Average sperm concentration at 2 months after the treatment by the drug was higher than the untreated value, although this was statistically not significant due to greater variations. Decrease in sperm count during the therapy was observed only in one patient. Sperm concentration of this case, however, was recovered and increased to higher levels after 6 months on the drug. No change was found in other semen parameters including sperm morphology. All hormone levels remained unchanged except for prolactin which increased. We conclude that etretinate did not cause suppression of spermatogenesis nor impairment of sperm motility or morphology as far as shown by the present observation periods.

Adolescent↗
PubMed1986

[Clinical evaluation of astromicin administered by intravenous drip infusion. Report III. Bacterial infections in the field of urology].

Intravenous drip infusion of a new aminoglycoside agent, astromicin (ASTM), was used for various urological infections, and its clinical efficacy and safety were studied. Each of almost all the patients tested was given 200 mg of ASTM twice a day by intravenous drip infusion. Among 114 cases with complicated urinary tract infections (UTI) evaluated according to the criteria for evaluation of drug efficacy in UTI, clinical response was excellent in 16, moderate in 54 and poor in 44. The efficacy rate was 61.4%. Among 137 cases who were evaluated for side effects, headache was observed in 1 case (0.7%), which recovered spontaneously the day after the withdrawal of the drug. Slight elevation in S-GOT, S-GPT, Al-P and others was observed in 12 cases (8.8%) as abnormal laboratory test values.

Adolescent↗