Search PubMed⌕ Search

Biomedical subjects

T Nakata

Publications and source records attributed to T Nakata.

At least 289 records · Page 16Linked to original sources
PubMed1985

[Clinical studies with cefoperazone in the biliary disease].

The concentration of cefoperazone (CPZ) in serum and bile was estimated after intravenous drip infusion of 1 g of the drug in 11 patients, who have performed cholecystectomy, choledocholithotomy and T-tube drainage for gallstone diseases. Administration of cefazolin (CEZ) 1 g was compared by the cross over method. After 1 g intravenous drip infusion of CPZ, the mean serum concentration was 88.3 +/- 24 micrograms/ml at 1 hour, 52 +/- 11.7 micrograms/ml at 2 hours and 36.5 +/- 10 micrograms/ml at 4 hours. The maintenance period of serum concentration was inclined to be longer in CPZ than in CEZ. After 1 g intravenous drip infusion of CPZ, the mean bile concentration reached to 810 +/- 459 micrograms/ml in 2 hours and it was maintained as high as 562 +/- 319 micrograms/ml even after 4 hours. On the other hand, after 1 g intravenous drip infusion of CEZ, the mean bile concentration was only 28.7 +/- 26 micrograms/ml in 1 hour and was low level in the progress. As compared with the highest concentration of CPZ and CEZ in same patient, the mean bile concentration of CPZ (942 +/- 525 micrograms/ml) was about 30 times higher than that of CEZ (28.6 +/- 26.3 micrograms/ml). There was no difference in the group of Gram-positive cocci between minimum inhibitory concentration (MIC) of CPZ and that of CEZ. While MIC of CEZ in the group of Gram-negative bacilli was from 0.78 to over 400 micrograms/ml, MIC of CPZ in that group was from 0.10 to 50 micrograms/ml. The value in CPZ was lower than that in CEZ at all strains. No side effects was seen in all patients.

Adult↗
PubMed1984

Mass screening for neuroblastoma in infants in Japan. Interim report of a mass screening study group.

A mass screening system for the early detection by means of a vanillylmandelic acid test of neuroblastoma in 6-month-old infants in Japan has been developed in eight districts. 16 of the 281 939 infants screened by this test had neuroblastoma, equivalent to a very high incidence of 1 in 17 621. 15 of the 16 children with neuroblastoma are alive; the other child died 1 month after surgery. This mass screening system for neuroblastoma used in infancy can help to improve prognosis in infants with this malignant disorder.

Adrenal Gland Neoplasms↗
PubMed1984

Substance P-like immunoreactivity in the pulp-dentine zone of human molar teeth demonstrated by indirect immunofluorescence.

Freshly-extracted human third molars were fixed in Zamboni fixative, demineralized with the mixture of EDTA and the fixative; substance P-like immunoreactivity (SPLI) was revealed by the indirect immunofluorescence technique of Coons. Substance P (SP) was observed in the pulp-dentine zone and the dental pulp. Some of SP-containing fibres ended at the odontoblast layer and did not reach the predentine; others terminated at the predentine surface or penetrated into the predentine. In the predentine, some of SP fibres accompanied odontoblast processes and ended near the mineralized dentine; others changed course transversely at various levels.

Dental Pulp↗
PubMed1984

Ultrastructure of granular materials in rat incisor enamel organ at early maturation stage.

With scanning electron microscopy, globules were seen in inter-cellular spaces between ameloblasts with ruffled borders and papillary cells at early maturation stage. Numerous globules were located on longitudinal folds between parallel ridges on the sides of ameloblasts, but only a few in the papillary layer. In previously-scanned specimens sectioned for transmission electron microscopy, the globules were composed of finely granular material. Vacuoles containing material identical to extra-cellular granules were observed in intra-cellular portions of the ameloblasts and papillary cells.

Ameloblasts↗
PubMed1984

[Autofluorescence of gastric cancer--study by flow cytometry].

Autofluorescence from cancer cells and non-cancerous cells of the stomach was measured by flow cytometry. The number of cells with fluorescence and its intensity was higher in cancer than in the surrounding mucosa. Preliminary results suggest that, if fluorescence emission from non-cellular substances is eliminated, measurement of fluorescence excited by laser illumination would permit earlier detection of gastric cancer.

Aged↗
PubMed1983

Scanning electron microscopy of the papillary layer of the rat-incisor enamel organ.

The enamel organ isolated from the maturation zone was treated with hydrochloric acid to remove such extracellular materials as collagen fibrils and basal lamina covering the papillary layer. Two types of the ridges were classified on the basis of their morphology and distribution: (1) globular and irregularly arranged ridges at the periphery of the early maturation zone, (2) elliptical and parallel ridges in the central part of this zone and over the whole of the late maturation zone. The fine surface structures of the ridges were characterized by numerous interdigitating cell processes.

Animals↗
PubMed1983

[Transitory abnormal myelopoiesis of the monoblastic form in a newborn infant with Down's syndrome and liver cirrhosis].

A case of 5-day old newborn infant with trisomy 21, who presented a leucocytosis (151 000/ml) with 60% of monoblasts and marked hepatosplenomegaly is reported. Transient abnormal myelopoiesis (TAM) was retained. TAM regressed spontaneously. However the baby died at the age of 50 days. The autopsy showed extramedullary hematopoiesis with marked monocytosis and liver cirrhosis of neonatal hepatitic origin. The pathogenesis of TAM in this case was discussed.

Bone Marrow↗
PubMed1983

[Determination of malignancy of cartilaginous tumors (2). Determination of malignancy by nuclear DNA contents and their distribution patterns in cartilaginous tumors].

In 40 different types of cartilaginous tumors, the number of binuclear cells was calculated and DNA content was examined using fluorescent Feulgen cytophotometric technique. In 7 enchondromas and 1 synovial chondromatosis, the DNA content was diploid in 7 and hypotetraploid in 1, and showed a unimodal normal distribution. The number of binuclear cells was 0.1-0.45%, and the mean DNA content was below 4. These cases showed no evidence of disease after curettage and bone graft. The follow-up period was from 4 years 6 months to 7 years 1 month, averaging 6 years 2 months. In 2 enchondromatoses and 2 benign chondroblastomas, the DNA content was diploid and showed a unimodal normal distribution. One chondromyxoid fibroma showed a broad-unimodal tetraploid distribution, and one benign chondroblastoma showed a broad-aneuploid distribution. The nuclear DNA content was sometimes histologically similar to that of chondrosarcoma in some benign cartilaginous tumors. In 5 secondary chondrosarcomas, the DNA content was hypo- or hypertetraploid, hexaploid, and showed broad-unimodal or broad-bimodal distribution. The number of binuclear cells was from 13% to 23%. Although the size of the nucleus was small, the number of binuclear cells was evidently numerous. The preferred treatment for secondary chondrosarcoma is principally wide resection, but amputation is sometimes indicated in cases of recurrence and large tumor size. The follow-up period was from 2 years 2 months to 18 years 11 months, averaging 9 years 11 months. All 5 patients were surviving at the time of follow-up. The DNA content in chondrosarcoma was mostly hypo- or hypertetraploid, hexaploid, or octaploid and showed broad-unimodal, broad-bimodal or broad-aneuploid distribution. The number of binuclear cells was 0.55-3.5%. The mean DNA content was proportional to the number of binuclear cells, the positive correlation between the mean DNA content and the number of binuclear cells was found (p less than 1%).

Adolescent↗