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Biomedical subjects

T Morishima

Publications and source records attributed to T Morishima.

At least 199 records · Page 11Linked to original sources
PubMed1983

Acycloguanosine therapy of the localized form of herpes simplex virus infection in a low-birth-weight infant.

It is known that the localized form of herpes simplex virus (HSV) infection does not always show a good prognosis. A preterm infant who evidenced skin and tongue lesions, caused by HSV type 1, was treated by acycloguanosine. The result was satisfactory without any complications. Therefore, a localized form of HSV infection of the newborn infant, even though the patient has a low-birth-weight, should be treated by the drug immediately after the observation of the positive HSV culture.

Acyclovir↗
PubMed1983

Local T cell subsets in mumps meningitis.

In the acute phase of mumps meningitis, more than 85% of the cells in cerebrospinal fluid (CSF) were OKT 3 positive, while 76% of the peripheral mononuclear cells (PMN) were OKT 3 positive. The ratio of OKT 4:8 positive cells in CSF was significantly lower than that in PMN, showing that suppressor/cytotoxic T cells had selectively accumulated in CSF. In addition, 58% of CSF cells were immune associated (Ia) positive, probably activated T cells.

Cerebrospinal Fluid↗
PubMed1983

Formaldehyde-induced fluorescence method for touch preparations from amelanotic melanoma tissues: a simple and rapid method for the demonstration of melanogenic activities of amelanotic melanoma cells.

Touch preparations from four amelanotic melanoma tissue samples were studied with the formaldehyde-induced fluorescence method. Fluorescent amelanotic melanoma cells could easily be detected under a fluorescence microscope. The fluorescence microscopic pictures obtained by the touch-fluorescence method were equally evaluated with those obtained by the classical fluorescence method. The method made it possible to demonstrate the melanogenic activity of amelanotic melanoma cells within 30 min. The routine application of this method to the diagnosis of amelanotic melanoma is suggested.

Fluorescence↗
PubMed1983

[Study on distribution to oral tissues of long acting amoxicillin].

The distribution of L-AMPC, a newly developed long acting amoxicillin granules, was studied in oral tissues using New Zealand White rabbits. The antibiotic was dosed at 20 mg/kg and the tissue concentrations were measured in the tongue, gingiva, submaxillary gland, cervical lymph node and the parotid gland. Amoxicillin concentrations in liver and kidney were monitored for reference and urinary recovery was measured over 5 hours. All tissue concentrations were both high and persistent whereas amoxicillin concentrations in kidney and liver were high and low, respectively, the observation consistent with the published data for amoxicillin.

Amoxicillin↗
PubMed1981

The effect of rectal administration of insulin on the short-term treatment of alloxan-diabetic dogs.

Six alloxan-diabetic dogs with fasting plasma glucose levels above 200 mg/100 mL were treated with rectal administration of insulin suppositories twice a day for 6--9 days. The effectiveness was compared with that of subcutaneous insulin injections. In three diabetic dogs with fasting plasma glucose levels below 300 mg/100 mL, both insulin suppository at a dose of 20 U (2.3 U/kg) and subcutaneous insulin at a dose of 0.2 U/kg showed a similar effect in reducing fasting glucose levels and daily urinary glucose amounts. In dogs with higher fasting glucose levels, 0.5 U of subcutaneous insulin/kg is less effective in reducing fasting glucose than 50 U (5.2 U/kg) suppositories, in spite of the same effects on daily urinary glucose output. Postprandial glucose responses were significantly lessened with rectal administration of insulin suppositories. The integrated area of increase in peripheral insulin concentration after subcutaneous infection of 0.2 or 0.5 U insulin/kg was significantly greater than that after rectal administration of an insulin suppository (2.3 or 5.2 U/kg, respectively). These results indicate that diabetes could be controlled by the daily rectal administration of an insulin suppository instead of the conventional subcutaneous injection.

Animals↗
PubMed1981

Urinary excretion of 5-S-cysteinyldopa in healthy Japanese.

Urinary excretion of 5-S-cysteinyldopa was investigated in 20 healthy Japanese (10 men and 10 women). The values of excretion varied between 46 and 193 microgram/24 h. The mean (+/- S.D.) was 96 1 +/- 9.8 microgram/24 h. It was higher in the men than in the women, being 13 +/- 15 vis-a-vis 80.8 +/- 11.4 microgram/24 h. This finding indicates that 5-S-cysteinyldopa is formed and excreted by active melanocytes even in Mongoloids. The excretion of dopa and dopamine was found not correlative with the excretion of 5-S-cysteinyldopa.

Adolescent↗
PubMed1980

Local immunity in mumps meningitis.

Titers of antibodies to mumps and measles virus and interferon activity were measured in sera and CSF obtained from 15 children with mumps meningitis. Antibody to mumps virus was found in 11 of 15 CSF samples. Evaluation of the CSF-serum ratio for antibodies to both viruses showed a substantially higher ratio for antibody to mumps virus. The ratio of IgG/IgM antibody activity to mumps virus was greater in CSF than in sera. These results could be attributed to antibody synthesis, particularly IgG, in the CNS. Titers of antibodies to mumps virus in CSF increased rapidly, reaching a peak four to ten days from onset of meningitis, and swiftly decreased thereafter. During the acute phase, interferon activity was found in almost all cases ranging from 16 to 128 IU/mL in sera, and 4 to 16 IU/mL in CSF. In cases of mumps meningitis that followed the usual clinical course, interferon disappeared within a week, whereas it persisted in the CSF in cases of persistent pleocytosis.

Antibodies, Viral↗
PubMed1980

Changes of the rotavirus concentration in faeces during the course of acute gastroenteritis as determined by the immune adherence hemagglutination test.

Concentrations of rotavirus were studied in serially sampled faecal specimens from 55 patients with acute gastroenteritis, utilizing the immune adherence hemagglutination (IAHA) test. Rotavirus antigen was detected in 45 (82%) out of 55 cases. In the faeces which were positive for rotavirus antigen, the concentrations reached their maximum titer shortly after the onset of the illness and diminished gradually until the 9th day.

Acute Disease↗
PubMed1980

Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus.

Peritoneal macrophages obtained from mice after an intraperitoneal injection of tryptose peptone inhibited the development of herpes simplex virus type 2 plaques in syngeneic mouse embryonic fibroblasts. In contrast, peritoneal macrophages, spleen cells, and thymocytes from untreated mice showed only a minimal inhibitory effect on the development of viral plaques. The effect was age dependent. Macrophages from 2 and 3-week-old mice showed weaker functions, requiring a larger number of cells for an equivalent reduction of plaques and virus yield than those from adult mice. When macrophages were treated with procaine, their phagocytic activity was completely abolished. However the procaine-treated macrophages still could inhibit the development of viral plaques. Peritoneal macrophages did not show any increased cytotoxicity against herpes simplex virus-infected cells; plaque inhibition might rather be attributable to their cytostatic effects on target cells.

Aging↗