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Biomedical subjects

T Miyake

Publications and source records attributed to T Miyake.

At least 325 records · Page 18Linked to original sources
PubMed1987

[Screening for endometrial cancer using a curettage stamp method].

The present study shows the value of a routine screening program for the detection of endometrial malignancies. From 1980 to 1985, 5,640 subjects were screened for endometrial malignancies using the curettage stamp method. Of 60 cases whose smears were abnormal, 25 were found to have malignant lesions. These patients included endometrial cancer (15 cases), sarcoma (3 cases) and metastatic cancer (4 cases). Three cases were found to have cervical cancer. Among 22 patients, excluding 3 cases with cervical cancer, 17 cases had negative results in a cervical smear test. Also 3 cases of endometrial cancer showed no history of abnormal genital bleeding. All 15 patients with endometrial cancer were over 40 years of age. These results indicated the clinical importance of the routine endometrial cytological smear in the detection of malignancies of the uterine body, especially in women over 40 years of age.

Adult↗
PubMed1987

Cobalamin-binding protein in gastric juice as a new tumor marker in gastric cancer.

Cobalamin-binding protein (binder) in gastric juice was studied as a biochemical marker of gastric cancer. Fasting gastric juice of cancer patients and controls with benign disease was used for separation of cobalamin binders by gel filtration and DEAE-cellulose column chromatography. Physicochemical properties of the binder in gastric cancer patients were shown to have a larger molecular size and more acidic isoelectric point than the control binder. The binder was found in the gastric juice of all patients with early gastric cancer. Detection of the binder may be clinically valuable as a possible marker in the diagnosis of gastric cancer.

Chromatography, DEAE-Cellulose↗
PubMed1987

[Treatment of gynecological cancer with cis-platinum].

Seven patients with gynecological cancer were treated with cis-platinum. Cis-platinum at 50 mg/m2 was administered by intravenous infusion for 2 hours, followed by 2,000 ml of intravenous fluid. This treatment was repeated every three weeks. Five of the seven patients were evaluable. These patients included those with ovarian cancer (3 cases), metastatic ovarian cancer (1 case), and endometrial cancer (1 case). One patient attained a complete response, two a partial response, and two showed progressive disease. The response rate for both complete and partial response was 60%. Gastrointestinal symptoms were most frequently found. Nephrotoxicity was generally mild, but one patient had to discontinue cis-platinum treatment due to severe nephrotoxicity. Cis-platinum treatment is considered to be effective and useful for gynecological cancer. Second-look operation and two-channel chemotherapy were also discussed in this paper.

Adenocarcinoma↗
PubMed1987

Central signals of gallstones in magnetic resonance imaging.

The magnetic resonance imaging of gallstones was studied in 34 patients. Diagnosis of the gallstones using magnetic resonance imaging was possible in 29 patients (85%). The gallstones showed as no-signal areas in all cases, with relatively strong signals being detected from the center of the stones in six cases. Postoperative studies showed the stones with the central signals to be of the so-called mixed stone type, in which the central area consists of cholesterol with a radiating structure. The central signal was thought to originate in water that accumulates in the central cavity of the stone, the cavity not being isolated from the exterior of the stone and there being a passage of fluids. The central signal is a characteristic indication of the stone's structure.

Cholelithiasis↗
PubMed1986

Scoring method for identifying patients with Kawasaki disease at high risk of coronary artery aneurysms.

The beneficial effect of immunoglobulin in preventing coronary artery aneurysms in patients with Kawasaki disease is recognized, but immunoglobulin should be selectively given to patients at high risk for coronary lesions. The present study was designed to present a scoring method to evaluate the severity of Kawasaki disease in terms of coronary artery disease based on clinical and early laboratory findings. Seventy-eight patients who were admitted at 4 to 7 days of illness and who had received aspirin alone during the acute febrile period were separated into 2 groups according to significant coronary artery involvement, and possible related factors to the discrimination of the 2 groups were studied using multivariate analysis. Age at onset, C-reactive protein and platelet count contributed significantly to the discrimination, and from these 3 items a simple scoring system was devised to predict patients at high risk for coronary lesions. Retrospective study using this scoring method indicated that significant coronary artery disease was more often seen in patients predicted to be at high risk treated with aspirin, while no patients who received immunoglobulin had coronary lesions of moderate or severe degree. Thus, the present scoring method provides simple but clinically useful criteria for predicting patients at high risk of coronary artery disease, and immunoglobulin therapy for selected patients may reduce the significant coronary artery complications of Kawasaki disease.

Coronary Disease↗
PubMed1986

Clinical application of an ultrasonic duplex system in the quantitative measurement of portal blood flow.

The ultrasonic duplex system, which is composed of a pulsed Doppler flowmeter and a linear array B-mode scanner, was developed for the purpose of quantitative transcutaneous measurement of blood flow. It was applied here to the study of portal blood flow in a normal series with healthy volunteers as subjects. A preliminary experiment, prepared by setting up a simulation model for blood circulation, demonstrated an excellent correlation between values obtained with the electromagnetic flowmeter (EMF) and the combined ultrasonic B-mode and Doppler system (duplex system). This was confirmed in vivo in a study of blood flow in the canine vena cava. The portal blood flow in 88 healthy adult volunteers ranging in age from 18 to 55 years (average 34.3) was studied using this equipment. Blood flow in fasting subjects who were resting was 889 +/- 284 ml/min (mean +/- SD) or 16.3 +/- 5.0 ml/min/kg body weight (mean +/- SD).

Adolescent↗
PubMed1986

The association of pyoderma gangrenosum with ulcerative colitis in Japan.

A patient with pyoderma gangrenosum (PG) and ulcerative colitis (UC) is described. He had melena and systemic skin lesions. The skin lesions consisted of small discrete ulcers on the back and head and large punched-out ulcers on the legs. He was successfully treated with prednisolone and salazosulfapyridine. He became asymptomatic after two weeks' treatment. Although the association of PG with UC is well documented among Caucasians, it is very rare among Japanese.

Adult↗
PubMed1986

Hemodynamics of splenic artery aneurysm.

Blood flow volume of the portal venous system of 3 patients with splenic artery aneurysm, an uncommon disease, was measured using an ultrasonic duplex system. A huge increase in splenic blood flow volume was found in each case. A large portasystemic shunt through which the portal blood flowed hepatofugally was present in 2 cases. We suspect the shunt is partially responsible for an increase in splenic blood flow volume, which would lead to the formation of splenic artery aneurysm together with portal hypertension.

Adult↗
PubMed1986

Measurement of portal vascular resistance in patients with portal hypertension.

Portal vascular resistance was measured percutaneously in 60 patients with chronic liver disease and in 5 control subjects. The portal vascular resistance (PVR) was calculated, using the following equation, from the portal blood flow (QPV), portal venous pressure (PPV), and hepatic venous pressure (PHV): PVR = (PPV - PHV)/QPV. The portal blood flow was measured using an ultrasonic Doppler duplex system, and the portal venous and hepatic venous pressures were measured using percutaneous transhepatic catheterization and venous catheterization, respectively. The wedged hepatic venous pressure was measured by occluding the hepatic venous branch using a balloon catheter. The portal vascular resistance was 0.25 +/- 0.13 mmHg X ml-1 X min X kg body weight (mean +/- SD, n = 5) in the control group, 0.64 +/- 0.29 mmHg X ml-1 X min X kg body wt (n = 13) in the chronic active hepatitis group, 1.34 +/- 0.79 mmHg X ml-1 X min X kg body wt (n = 30) in the cirrhosis group, and 0.85 +/- 0.69 mmHg X ml-1 X min X kg body wt (n = 13) in the idiopathic portal hypertension group.

Blood Flow Velocity↗
PubMed1986

Inherited deficiency of the seventh component of complement associated with meningococcal meningitis: lack of serum bactericidal activity against Neisseria meningitidis in a girl with C7 deficiency and HLA studies of a C7-deficient Japanese family.

An 8-year-old girl with meningococcal meningitis lacked serum complement activity. The seventh component of complement (C7) could not be detected in her serum by either functional or immunochemical analysis. The levels of the other components were within the normal range. Her serum complement activity was restored by the addition of purified C7. Her fresh serum showed a total absence of bactericidal activity against Neisseria meningitidis, group Y, but her serum bactericidal activity was restored by the addition of purified C7. The restoration of her serum bactericidal activity was completely inhibited in the presence of Mg2+ EGTA. These findings suggest that restoration of the bactericidal activity of her serum against N. meningitidis might be mediated by the specific antibody against N. meningitidis and the reconstituted complement system in her serum. Heterozygous deficiency of C7 was found in 10 of her family members. Genetic studies showed that the mode of inheritance might be an autosomal codominant trait. No genetic linkage between deficiency of C7 and the HLA system was found.

Blood Bactericidal Activity↗
PubMed1986

Portal hemodynamics in patients with hepatocellular carcinoma.

The protal blood flow was assessed in 46 patients with hepatocellular carcinoma, 81 with cirrhosis, and 110 control subjects using an ultrasonic B-mode pulsed Doppler duplex system. The cross-sectional area of the portal vein was increased, and the velocity of portal blood flow was decreased in hepatocellular carcinoma and cirrhosis, whereas the blood flow volume was not significantly different. A significant decrease in portal blood flow was found in hepatocellular carcinoma only when at least three of the four major branches of the portal vein were occluded. The change in portal hemodynamics before and after transcatheter arterial embolization (TAE) was investigated. Immediately after TAE, neither portal venous pressure nor portal blood flow showed any constant trend. The portal blood flow reached a peak 1 week after TAE and then returned to its former value after 3-4 weeks, while all cases with poor prognoses showed a drop in portal blood flow after TAE.

Aged↗