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Biomedical subjects

T Matsuda

Publications and source records attributed to T Matsuda.

At least 1,423 records · Page 79Linked to original sources
PubMed1986

Effect of activated lymphocytes on the regulation of hematopoiesis: enhancement and suppression of in vitro BFU-E growth by T cells stimulated by autologous non-T cells.

Autologous mixed lymphocyte culture (AMLR) is an immunologic response with memory and specificity and plays a role in immune regulation. Effects of T cells activated by AMLR were studied in the regulation of in vitro erythropoiesis. AMLR-activated T cells were cocultured with autologous non-T, nonphagocytic peripheral blood mononuclear cells for assaying erythroid progenitor cells (BFU-E). T cells activated for 3 days in AMLR showed significant enhancement of in vitro colony growth by BFU-E. In contrast, activated T cells from day 7 AMLR caused significant suppression of BFU-E growth. Both enhancing and suppressing activities of AMLR-activated T cells were mediated by an la-positive and radiosensitive population within the OKT4+ subset. These observations suggest that AMLR-activated T cells may play a role in the immune-mediated regulation of in vitro erythropoiesis. It is also suggested that heterogeneous T-cell subsets may exert regulatory functions in the regulation of in vitro hematopoiesis.

Antibodies, Monoclonal↗
PubMed1986

On the ovarian bursa of the golden hamster. I. Scanning electron microscopy of the inner surface and stomatal orifices.

The inner surface of the ovarian bursa in the golden hamster was observed by scanning electron microscopy. There were numerous discontinuities in the bursal epithelium. Crevice-like gaps were formed between irregularly spaced epithelial cells, and the subepithelial connective tissue was exposed to the bursal cavity through the gaps. Through circular defects in the epithelial lining or pores, which were less than 20 microns in diameter, either the subepithelial connective tissue or stomatal orifices were visible. There were smooth surfaced areas lined with lymphatic endothelium, instead of bursal epithelium, which was continuous from the wall of the lymphatic vessel to the inner surface of the bursa. These areas were not present in all bursae, but if they were present, stomatal orifices consistently opened in them. Stomata in the ovarian bursa had two types of orifices, (1) circular orifices opening predominantly in smooth surfaced areas and measuring up to 50 microns in diameter; (2) jagged orifices opening usually in pores and measuring less than 10 microns in diameter. Blood cell components derived from ovulation entered lymphatics via stomata. Bursal fluid and small particles may drain into lymphatics directly via stomata and indirectly by diffusion through gaps, pores and connective tissue. Judging from the structural appearance of the stomatal orifices, the degree of opening of jagged orifices may change in response to changes in the cavity, while circular orifices may be stable openings.

Animals↗
PubMed1986

Disseminated hyalohyphomycosis in a leukemic patient.

A 69-year-old man with acute myeloblastic leukemia was admitted to the hospital for induction chemotherapy. A complication caused by a disseminated mycotic infection occurred while the neutropenic patient was maintained on a course of cytotoxic drugs, antibiotics, and corticosteroid therapy. The causal isolate was identified as Fusarium solani on the basis of its colonial and microscopic morphology. This fungus developed in the patient's tissue in the form of hyaline, branched, septate hyphae. This case fits the definition of the disease entity known as hyalohyphomycosis. The term hyalohyphomycosis encompasses infections caused by various nondematiaceous opportunistic fungi with a filamentous tissue form. The purpose of this article is to review and discuss the literature on hyalohyphomycosis caused by Fusarium species. Combined histopathologic and mycologic findings were evaluated to determine the nature of opportunistic mycotic infections.

Dermatomycoses↗