[Late clinical results in 170 patients operated on for mitral stenosis. Their return to work].
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Biomedical subjects
Publications and source records attributed to T Maros.
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On the basis of data from the literature, as well as on his personal experience, the author defines a series of notions concerning the structural particularities of the terminal choledocus, highly interesting from the surgical view point. It is shown that at this level a valve exists, with a special structure, as well as a complex sphincteral system, highly refined in its functions, that should be carefully preserved, within the possibilities of techniques applied during surgical interventions.
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The nervous elements of the extrahepatic bile ducts were studied on serial sections prepared from rabbit and human embryos and foetuses, using silver impregnation techniques. In the gallbladder of rabbit embryos and foetuses, the nervous elements are absent, whereas the bile ducts possess a dense parasympathetic vegetative plexus. In human embryos, the muscular layers and submucosa of the gallbladder and bile ducts have well developed parasympathetic plexuses and a sympathetic subserous plexus, without nerve cells, respectively. The histotopical identification of nervous elements in the bile ducts allows the distinction of parasympathetic plexuses from the sympathetic ones.
Using the model of cholestasis after ligation of the common bile duct in the rat, some aspects concerning the ductular neoformation were studied. The authors' observations sustain the hepatocytic origin of neoformed tubular structures by a process of regressive metamorphosis of the hepatic cells which is to be considered as a dedifferentiation phenomenon. Neocanaliculi appear in relation with hyperplastic connective tissue through which the liver could regain its embryofetal cholangiogenesis.
Injecting urine obtained from patients suffering from hepatitis (acute and chronic-active), into the dorsal lymph sac of 336 frogs, the authors repeatedly observed serious motor disturbances, which caused the death of animals, in proportion of 66%. Histologically, in the treated animals grave neuronal lesions appear (reaching sclerosis and disintegration of motor neurons) at the level of the midbrain, pons and medulla oblongata, attaining the highest degree in the motor zones of the ventral horns, of the spinal cord. In the control group (200 frogs), treated in the same manner with urine originating from healthy persons, the mortality was only 6%. It is concluded that in the active stage of hepatites, in the urine of the patients cytolytic substances of a definite neurotoxic action appear, which is manifest by motor disorders and grave dystrophic lesions of the brainstem and spinal cord.
Comparative studies on three-dimensional models give new possibilities in examination of the internal and external evolution of the thymus, phenomena that occur concomitantly with the histogenesis of the organ during the fetal life period. During the antenatal period, the invasion and burgeoning of capillaries represent a strong potential of biostimulation with a special role in organizing and determining thymus lobulation.
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