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T Maeda

Publications and source records attributed to T Maeda.

At least 1,279 records · Page 71Linked to original sources
PubMed1984

[Morphological study on innervation of the cerebrospinal blood vessels. II. Spinal blood vessels].

The distribution patterns of aminergic and cholinergic nerve fibers in the feline spinal blood vessels were studied by means of amine histofluorescence and acetylcholinesterase (AChE) staining. The anterior spinal artery had a dense network of aminergic and AChE-positive (probably cholinergic) nerve fibers. The posterior spinal vein, in contrast, had only aminergic nerve fibers. Intraparenchymal small blood vessels in the spinal cord also had strongly fluorescent (probably peripheral) aminergic nerve fibers. This was quite a characteristic feature in the spinal cord. The distribution pattern and the density of these two sorts of nerve fibers widely varied with the individual segment of the spinal cord. The thoracic spinal cord had the lowest number of these nerve fibers throughout the spinal cord. This fact may give a clue to explain why the thoracic spinal cord is most susceptible to ischemic change.

Acetylcholinesterase↗
PubMed1984

[Peptidergic innervation of the cerebral blood vessels--an immunohistochemical study].

By an immunohistochemical technique, vasoactive polypeptide (VIP)-and substance P-containing nerve fibers are observed in the cerebral blood vessels. VIP-containing nerve fibers distribute in a spiral pattern, similar to the muscle cell distribution pattern. Under an electron microscopic observation, VIP-immunoreactive terminals lie just near to a muscle cell in the inner layer of the adventitia. In contrast, substance P-containing nerve fibers show a meshwork pattern in the outer layer of the adventitia. In combination of acetylcholinesterase (AChE) staining and VIP immunohistochemistry, AChE-positive and VIP-immunoreactive nerve fibers reveal almost same distribution in the same specimen. The present data suggest that VIP-containing nerve fibers may play a role of smooth muscle control of the blood vessels, while substance P-containing nerve fibers may not take part in muscle control.

Animals↗
PubMed1984

[A statistical study of management based on prognostic factors after surgical treatment for cervical carcinoma].

In order to improve the therapeutic results after surgical treatment for cervical carcinoma, 236 patients treated from 1969 to 1976, who could be followed up for five years, were analyzed retrospectively. Various prognostic factors were studied by principal component analysis (quantification method III), and criteria of risk of recurrence were established. Using the discriminant function obtained, another series of 246 patients treated surgically experienced from 1977 to 1982, whose clinical stages were Ib or more, were divided into three groups according to the risk of recurrence and were managed accordingly. The patients in groups II and III, in whom recurrence was possible, received continuous adjuvant chemotherapy with Tegafur (400-600mg/day). The results obtained were as follows. In the principal component analysis, coefficients for the clinical stage, invasion into the parametrium, location of carcinoma and invasion into the uterine body were high on the X1-axis, considered to represent the tumor volume. On the X2-axis, considered to represent the tumor biological characteristics, coefficients of the histological type, CPL classification and lymph node metastasis were high. The risk of recurrence was calculated by the following discriminant function; Z = 0.810X1 + 0.710X2. The values obtained were Z less than 0.053 in group I, 0.053 less than or equal to Z less than 0.376 in group II and Z greater than or equal to 0.376 in group III. Using the equation, 246 cases from 1972 to 1982 were prospectively divided into three groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1984

[Morphological study on innervation of the cerebrospinal blood vessels. I. Cerebral blood vessels].

The distribution of nerve fibers in the cerebral blood vessels was studied by a catecholamine histofluorescence method, acetylcholinesterase (AChE) staining and immunohistochemistry. The ultrastructure of the terminal boutons in the vessel wall was also studied. In the adventitia of the cerebral artery, green fluorescence aminergic fibers and brownish AChE-positive (probably cholinergic) fibers were observed. In contrast, the cerebral venous system showed no AChE-positive fibers. The highest density of aminergic fibers were found in the dural sinus and the second highest in the internal cerebral vein. Serotonin immunoreactive nerve fibers were found along small intraparenchymal blood vessels such as perforating arteries in the brain stem, and arterioles and venules in the cerebral cortex. Under ultrastructural observation, a serotonin immunoreactive terminal was demonstrated in conjunction with the basement membrane of the capillary.

Acetylcholinesterase↗
PubMed1984

[Primary intracranial hypotension associated with chronic subdural hematoma--report of 2 cases].

Low spinal fluid pressure syndrome is characterized by orthostatic headache aggravated in upright position. It is classified into two from etiological standpoint i.e. primary and secondary (most often seen after lumbar puncture). On the other hand, low spinal fluid pressure is one of the promoting factors of chronic subdural hematoma. We report 2 cases of primary low spinal fluid pressure syndrome (primary intracranial hypotension) associated with chronic subdural hematoma. Case 1 is a 47-year-old man who was admitted with disorientation following 2 week history of orthostatic headache. Spinal fluid pressure was 7mmH2O in the lateral recumbent position. CT scan revealed bilateral isodense chronic subdural hematoma. The subdural hematoma reaccumulated 17 days after the first operation. Case 2 is a 31-year-old woman who was admitted with 4 week history of progressive orthostatic headache accompanied by nausea and vomiting. Spinal fluid pressure was 0 mmH2O. CT scan and cerebral angiography showed bilateral chronic subdural hematoma. The hematoma reaccumulated 20 days after the first operation. Six cases including our two cases of primary intracranial hypotention associated with chronic subdural hematoma have been reported. When changes of characters of headache, especially mental symptoms and disturbances of consciousness occurred in patients with chronic orthostatic headache, association of chronic subdural hematoma should be suspected. In cases with chronic subdural hematoma associated with low spinal fluid pressure syndrome, the reaccumulation of hematoma tends to occur after burr hole opening and irrigation of hematoma.

Adult↗
PubMed1984

Antitumor activity of sediment fractions from Fusobacterium nucleatum culture supernatant.

The present study was carried out to examine antitumor activity of extracts from Fusobacterium nucleatum culture supernatant. The extracts were prepared as sediment fractions by ethanol precipitation, isoelectric point precipitation and proteolytic enzyme-treatment. An ethanol fraction obtained by addition of 60% ethanol to the culture supernatant showed effective antitumor activity to ascites and solid type tumor of Ehrlich carcinoma and also to solid type tumor of Sarcoma 180 in ICR mice. A sediment fraction extracted by adjusting an ethanol fraction to pH 4.0 was also found to give distinctive antitumor activity to Ehrlich ascites carcinoma. This fraction was further treated with pronase to eliminate free nucleotides, and then ultrafiltrated. The pronase-treated fraction gave better antitumor activity to both ascites and solid type tumor of Ehrlich carcinoma or Sarcoma 180. The ratios (%) indicating antitumor activity ranged from 131 to 188% even at 4-8 weeks after the tumor cell inoculation.

Animals↗