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Biomedical subjects

T Koide

Publications and source records attributed to T Koide.

At least 415 records · Page 23Linked to original sources
PubMed1980

Inhibition of (3H)-dopamine uptake into rat brain synaptosomes by the new non-tricyclic antidepressants, FS32 and FS97.

The effects of new non-tricyclic antidepressants, FS32 and its desmethylated compound (FS97), on the uptake of (3H)-dopamine (DA) by rat purified whole brain synaptosomes and the striatal synaptosomes were studied. The uptake into synaptosomes was time- and temperature-dependent and was saturable with a Km value of 9.1 X 10(-8) M. The inhibiting activities of both compounds were comparable to those of amitriptyline, nortriptyline and iprindole, and were nearly twice the activity of imipramine and desipramine. The kinetic constants indicated that both FS32 and FS97 were competitive inhibitors of (3H)-DA uptake. Neither drug caused a significant release of (3H)-DA from the synaptosomes.

Animals↗
PubMed1980

Variable prognosis in congestive cardiomyopathy. Role of left ventricular function, alcoholism, and pulmonary thrombosis.

Prognosis of 36 patients with congestive cardiomyopathy was studied in relation to various clinical factors. Half life of the survival curve after overt heart failure was about 7 years. Although left ventricular function was a major determinant of clinical course in congestive cardiomyopathy in general, its relation to prognosis was variable according to the type of cardiac involvement. In peripartal cardiomyopathy and in a type of cardiomyopathy named subacute cardiomyopathy with pulmonary thrombosis in this paper, factor(s) other than left ventricular function, possibly including pulmonary thrombosis, may be operative as more important determinant of extremely poor prognosis in these subtypes. Alcoholic cardiomyopathy was also unique in its favorable prognosis in association with reversible cardiomegaly following abstention from alcohol.

Adult↗
PubMed1979

Isolation and characterization of antithrombin III from human, porcine and rabbit plasma, and rat serum.

1. Human, porcine, rabbit, and rat antithrombin III have been purified by affinity chromatography using heparin-agarose. The amino acid and carbohydrate compositions, amino-terminal sequences, immunological cross-reactivities, and inhibitions of human thrombin were studied. 2. Human, porcine, rabbit, and rat antithrombin III are single-chain glycoproteins containing hexose, glucosamine, and neuraminic acid. 3. The total carbohydrate contents were 17, 16, 14, and 15% for human, porcine, rabbit, and rat antithrombin III, respectively. 4. Molecular weights estimated from the migration in sodium dodecyl sulfate (SDS)-poly-acrylamide gel electrophoresis were 59,000, 58,000, 63,000, and 63,000 for human, porcine rabbit, and rat antithrombin III, respectively. 5. These four proteins have similar amino acid compositions, although some minor differences were noted. 6. Human, porcine, and rabbit antithrombin III have a histidine residue at the amino-terminus, while rat antithrombin III contains an amino-terminal asparagine residue. 7. The amino-terminal sequences up to the first 17 residues showed high homology among the four proteins. 8. Some immunological cross-reactivity was observed only between human and porcine antithrombin III. 9. The apparent dissociation constants (KI) for the complexes between human thrombin and human, porcine, rabbit, and rat antithrombin III were about 1.2 x 10(-10) M, 9.5 X 10 (-9) M, 1.4 X 10(-7) M, and 2.8 X 10(-9) M, respectively.

Amino Acid Sequence↗
PubMed1979

Calcification in augmentation mammoplasty.

Twenty-five cases of augmentation mammoplasty from among 1,600 routine mammograms were divided into paraffin and silicon compound groups. Calcification occurred in 11 cases and was seen in 75% of the paraffin group and 29% of the silicone group. The calcifications in the paraffin group were small, annular, and too numerous to be counted. They were diffusely distributed and tended to involve the lymph nodes. The calcifications in the silicone group were large, egg-shaped, localized, and fewer in number. Lymphadenopathy was rare. The two groups also differed in time elapsed between mammoplasty and mammography.

Adult↗
PubMed1979

Pharmacological studies on a new thymoleptic antidepressant, 1-[3-(dimethylamino)propyl]-5-methyl-3-phenyl-1H-indazole (FS-32).

Some pharmacological actions of 1-[3-(dimethylamino)propyl]-5-methyl-3-phenyl-1H-indazole (FS-32), a newly synthesized indazole derivative, were investigated in comparison with imipramine. FS-32 showed anti-reserpine activity in a dose-dependent manner, whereas imipramine exhibited a bell-shaped dose-response pattern. Catecholaminergic potentiation was demonstrated with FS-32. The results obtained from a norepinephrine potentiation test in vitro suggest that FS-32 may act in a manner qualitatively different from the tricyclic antidepressant. FS-32 produced a definite suppressive effect on isolation-induced fighting without affecting coordinated motor activity and on the duration of afterdischarge elicited by electrical stimulation to the amygdala or the hippocampus without producing a slow wave pattern in the EEG. Similar effects on fighting behavior and the afterdischarge were shown under imipramine with a slight motor incoordination and with a slow wave pattern, respectively. FS-32 produced practically no peripheral anti-cholinergic action, while it antagonized central cholinergic activity. FS-32 tended to produce an increase in chatecholamine content in the brain without MAO or COMT inhibitory activity. Norepinephrine uptake was inhibited by FS-32, but less than by imipramine. These pharmacological properties suggest a potential clinical utility of FS-32 as an antidepressant possessing thymoleptic activities.

Acetylcholine↗
PubMed1979

Development of the calyceal system in the human fetus.

The calyceal system including the papilla, infundibulum, and renal pelvis in human fetuses and neonates was studied histologically and chronologically. There was a considerable discrepancy between the development of the calyceal muscles and the papilla. The protuberant form of the papilla developed much earlier than the calyceal muscle which was observed in the late stage of intrauterine life. The calyceal muscles were differentiated and extended from the renal pelvic muscles through the infundibular muscles after approximately 21 weeks of intrauterine age and were not fully developed by the late stage of intrauterine life. On the other hand, the cup-shaped calyces and the protuberant form of the papilla developed into the form similar to that observed in the adult by the 21st week; their development began in the 16th week. From these observations the etiology of megacalyces was speculated and discussed based on the discrepancy of the muscular development of the calyceal wall and the development of the protuberant papilla.

Congenital Abnormalities↗
PubMed1979

[Clinical evaluation of cefamandole in infants and children (author's transl)].

Clinical trials were carried out with cafamandole (sodium salt) in pediatric infections. Results were as follows; 1. CMD was applied to 13 patients with pneumonia, 1 patient each with submandibular abscess, urinary tract infection and bacterial meningitis. 2. Results were excellent in 1 and good in 13 patients, being overall efficacy rate 93.3%. 3. Slight elevations of GOT and GPT were observed in 1 patient. No other serious side effects were observed or reported.

Acute Disease↗