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Biomedical subjects

T Kitahara

Publications and source records attributed to T Kitahara.

At least 217 records · Page 12Linked to original sources

[An operated case of cervical spontaneous hematomyelia].

We have reported a case of cervical spontaneous hematomyelia caused by cavernous hemangioma. A 47-year-old woman experienced a sudden onset of pain in the neck on 5 December 1979. One week after the onset she began to have tetraparesis. There was a rapidly increasing weakness of the extremities and she was referred to our department on 25 December 1979. At the time, the positive neurological findings were flaccid tetraplegia, bilateral loss of all sensory perception below the C4 level and urinary retention. Chest x-ray films demonstrated an elevation of right diaphragma. Roentgenograms of the cervical spine were normal. Emergency myelography via cisternal puncture revealed a central filling defect at the level of C3-C5. But there was no displacement of dentate ligament on lateral view, suggesting an intramedullary mass lesion. Laminectomy from C2 to Th1 and evacuation of the intramedullary blood clot at C3-C5 level were performed successfully. Microscopic examination of clots revealed cavernous hemangioma. The postoperative course was uneventful and the patient gradually improved in her motility. In the review of the literature including our case, vascular malformations are the commonest cause of spontaneous hematomyelia. They are found 12 out of 18 cases (Table 1). The symptoms of spontaneous hematomyelia are characterized by sudden onset of pain and rapid development of long tract sign in a previously asymptomatic individual. Operated cases are summarized in table 2. Good operative results are obtained 6 out 9 cases. We will emphasize that in a case of spontaneous hematomyelia with acute progression of transverse myelopathy, early diagnosis and operation are extremely important, and for this purpose, myelography is considered to be one of the most useful examinations.

Diagnosis, Differential↗

Reaction time of elbow flexion during passive movements.

The effect of passive movements of the elbow on biceps EMG reaction time (RT) was studied in 10 normal subjects. Each subject was required to perform a simple RT task, flexing the left elbow to a tone stimulus, under three different conditions: (a) during passive flexion (PFLX) of the elbow, (b) during passive extension (PEXT), and (c) without passive movements (STAT). A forearm-rotator was used to produce a constant movement with angular velocity of 20 deg/sec, and in each condition the tone stimulus was always presented at the same angle of the elbow joint. Significant differences in mean EMG-RTs were found between the three conditions; the shortest EMG-RT of all was observed in the PFLX condition (77.0 +/- 15.0 msec), followed by that in STAT (93.1 +/- 11.8 msec) and lastly in PEXT (116 +/- 23.1 msec). Neurophysiological mechanisms underlying these phenomena are discussed.

Adult↗

[A preliminary study of vincristine, methotrexate, and prednisolone (VM*P) combination chemotherapy for advanced adult non-Hodgkin's lymphoma].

The VM*P combination chemotherapy was administered to 13 patients with advanced (Stage III and IV) non-Hodgkin's lymphoma refractory to previous multiagent chemotherapy including cyclophosphamide (EX) and/or adriamycin (ADM). 1) Complete response was obtained in two patients with diffuse histiocytic lymphoma and one patient with diffuse undifferentiated (Burkitt type) lymphoma, and a response rate was 46.2%. 2) Tumor regression in responders was recognized within one week after administration of VM*P, but the duration of response was only 7(2-17) weeks in median (range). 3) Positive correlation was not seen between responsibility and dose of vincristine or methotrexate (MTX), but complete responders were obtained with only over 30 mg/dose of MTX. 4) In spite of resistant cases against EX and/or ADM, complete responders were obtained with VM*P therapy. Clinically, it was shown that cross resistance was minimal among MTX, EX and ADM. 5) Major side effects of VM*P therapy were myelosuppression (75%), hepatotoxicity (46%), and severe infection (23%). Neurotoxicity and nephrotoxicity were rare.

Adult↗

Treatment of biliary atresia: a study of our operative results.

The operative results in 87 biliary atresia cases were investigated from the aspect of the histologic findings in the liver and the remnant of the extrahepatic bile ducts, and the details of the operative procedures. The degree of liver fibrosis, the liver cell changes, and the type of extrahepatic bile ducts are closely related to our operative results. Our operative results have been improving since 1977 due to the advancement of microsurgical techniques and a new type of operative procedure for prevention of ascending cholangitis. Twenty-five of 29 cases (86.2%) surgically corrected are alive, showing bile excretion, and are in a satisfactory general condition.

Bile Ducts↗

Radioimmunoassay for human pancreatic secretory trypsin inhibitor: measurement of serum pancreatic secretory trypsin inhibitor in normal subjects and subjects with pancreatic diseases.

A reliable radioimmunoassay (RIA) for human pancreatic secretory trypsin inhibitor (PSTI) has been developed. The method is highly sensitive (0.4 ng/ml), reproducible and specific. A good parallel relationship was observed between the standard curve and dilution curves for serum and urine. The PSTI bound to trypsin-alpha 2-macroglobulin complexes was found not to be immunoreactive, whereas a part of the psti-trypsin complex was immuno-reactive. In healthy individuals, serum PSTI level ranged from 5.4 ng/ml to 16.0 ng/ml, the average being 11.3 ng/ml (S.D. +/- 2.7). Elevated values were observed in patients with acute pancreatitis (highest value 3200 ng/ml), and in some patients with chronic relapsing pancreatitis.

Acute Disease↗

Computed tomography in perinatal hypoxic and hypoglycemic encephalopathy with emphasis on follow-up studies.

Cranial computed tomography (CT) scans of 10 cases of perinatal hypoxia and 9 cases of perinatal hypoglycemia were reviewed. Emphasis was placed on follow-up studies. Periventricular hypodensity and intracranial (subarachnoidal and/or intraventricular) hemorrhage were the most frequent findings in the early CT scans of perinatal hypoxia. In the follow-up studies of the cases with periventricular hypodensity, return to normality was observed in most instances. In neonatal hypoglycemia, the findings were similar except for the rarity of intracranial bleeding.

Brain Diseases↗