The possible involvement of aluminum in Alzheimer's disease (AD) is discussed focusing, on the one hand, on a critical review of the analytical results concerning the brain aluminum content of AD patients, and on the other hand, on the in vitro interactions of AI(III) with biologically relevant potential AI(III) binders occurring in intracellular and/or extracellular fluids. The biomolecules considered are such as amino acids, organic and inorganic phosphates, nucleotides, catecholamines and transferrin. It is quite clear from the results that definition of the actual AI(III) species present in the biological systems is essentially important in any studies of the neurotoxic role of aluminum.

Journal Article↗

PubMedDate not supplied

[Speciation of bioactive Al(III) and VO(IV) complexes in biological systems].

The speciation of the toxic Al(III) and the beneficial VO(IV) in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in the organism. The possibility and the importance of ternary complex formation with relevant biomolecules is emphasised. The importance of the biospeciation of Al(III) ion in its transport and involvement in neurological disorders, and of insulin mimetic VO(IV) complexes is discussed.

Aluminum↗

PubMedDate not supplied

Follow-up examinations of laparoscopic cholecystectomies.

The postoperative complaints of patients having been subjected to laparoscopic cholecystectomy have been studied. Residual gallstones involving clinical symptoms have not been observed. Right subcostal pain, meteorism, and nausea due to faulty diet showed a slight difference in favour of the laparoscopic method when compared to traditional surgery. The laparoscopic method was qualified as excellent by over 95 per cent of the patients.

Adult↗

PubMedDate not supplied

Single-channel analysis of Pb2+ modified steady-state Na-conductance in snail neurons.

Patch-clamp technique was used in order to study properties of the steady-state Na-channel in snail neurons. Experiments revealed that Pb-ions, applied extracellularly, close these channels, which are preferably in open state at the resting membrane potential. Elementary currents have a linear current-voltage (I-V) relationship with single channel conductance of 14 pS between -100 and -40 mV both in control saline and in the presence of 50 microM Pb in the pipette. Pb-ions decreased the mean open and increased the mean closed time. It was found that both open and closed times showed little voltage-dependence, however the probabilities of the open and closed times proved to be voltage-dependent. Open and closed time histograms were fitted by one exponential, therefore first order kinetics were assumed for the blocking effect of Pb2+ at the single channel level.

Animals↗

PubMedDate not supplied

[Comparative physiological study of the processes of myocardial cellular stimulation].

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Action Potentials↗