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Biomedical subjects

T Katsumata

Publications and source records attributed to T Katsumata.

At least 145 records · Page 8Linked to original sources

[Coronary artery bypass grafting with all arterial grafts using the internal thoracic, the gastroepiploic and the inferior epigastric arteries].

CABG with all arterial grafts using both the internal thoracic artery (RITA, LITA), the right gastroepiploic artery (GEA) and the inferior epigastric artery (IEA) was performed in 26 patients from July 1989 to August 1991. There were no early and late deaths. Early postoperative coronary angiography in all patients revealed that the best choice of anastomosis was RITA to LAD, LITA to LCX or DIA, and GEA to RCA (type A). All arterial grafts CABG is safe and feasible, but the saphenus vein graft must be used to avoid the anastomosis from small GEA to small LCX.

Abdominal Muscles↗

[Blood purification after aorto-coronary bypass grafting for dialysis patients].

Four dialysis patients received aorto-coronary bypass grafting (CABG) at Fukuyama cardiovascular hospital from April 1989 to March 1992. We employed continuous ambulatory peritoneal dialysis (CAPD) in two cases, hemodialysis with extracorporeal ultrafiltration method (ECUM + HD) in one case and hemodiafiltration with continuous veno-venous hemofiltration (CVVHF + HDF) in one case for perioperative management. In each cases, intermittent HD was undergone during 4 days before operation. Intraoperatively, HD was used together with extracorporeal circulation. Blood pressure in the postoperative course changed more frequently in CAPD cases than ECUM + HD or CVVHF + HDF case. Especially, CVVHF + HDF stabilized the movement of circulation and kept balance of serum BUN, Cr after the operation (BUN; 27.2 +/- 6.3, Cr; 5.0 +/- 0.6). We concluded that CVVHF + HDF would be the most favorable method to maintain the fluid balance stably for the uremic patients after CABG.

Adult↗

[Successful repair of partial atrioventricular septal defect in a 70-year-old female patient].

A 70-year-old female with partial atrioventricular septal defect underwent a total correction of the anomaly. The patient was in NYHA functional class II. Preoperative cardiac catheterization demonstrated a primum-type atrial septal defect through which 33% of left to right shunt occurred and a cleft of mitral valve causing moderate regurgitation. The operative procedure as our routine for this anomaly consisted of suture of mitral septal commissure and closure of atrial septal defect with autologous pericardial patch. Postoperative examination showed satisfactory competence of mitral valve and improved functional capacity. A successful correction for the case aged more than 66 with this anomaly has not been reported so far in Japanese literature. We conclude that surgical treatment should be basically considered for this anomaly in spite of senility.

Aged↗

[A case report--successful surgical treatment of prosthetic aortic valve detachment with enlargement of sinuses of Valsalva caused by the recurrence of aortitis].

A successful operation on a 49-year-old female with aortitis syndrome associated with prosthetic aortic valve detachment was reported. Aortic valve replacement using SJM 25A had been performed for aortic regurgitation caused by aortitis. Though her C-reactive protein (CRP) was kept between (+/-) and (2+) with prednisolone administered, general fatigue suddenly appeared 4 years after the first operation. The blood sedimentation rate was 65 mm/30 min and CRP was (4+), and the echocardiography showed abnormal movement of the prosthetic valve with perivalvular leakage on admission. Aortography showed the valve detachment and abnormal movement due to enlargement of sinuses of Valsalva, one of which was transformed as a diverticulum and projected into Left ventricular cavity with moderate leakage. After the inflammation was well controlled, she was operated upon. Dilatation of sinuses, perforation of intima around the prosthetic valve were recognized as left ventricular-aortic discontinuity, but ascending aorta was not enlarged. So the prosthetic valve was suspended below coronary ostia with transmural mattress sutures from right atrium. Postoperative course was uneventful. The postoperative aortography revealed only trivial perivalvular leakage without abnormal movement of the valve. This was a rare case of the valve detachment in the aortitis patient.

Aortic Arch Syndromes↗

An anatomical study of a new method for enlargement of narrowed aortic annulus: intra-arterial aorto-infundibuloplasty.

A new procedure "intraarterial aorto-infundibuloplasty" for the narrowed aortic annulus is described. Aortic valve replacement is performed through an aorto-pulmonary and infundibular septal incision which is eventually enlarged by a single patch, i.e., a two-dimensional patch instead of a three-dimensional patch as in Konno's procedure. An anatomical study showed that a prosthetic valve three sizes larger than the natural annular diameter could be implanted and the natural annular diameter was increased by as much as 42%.

Animals↗

Biological potency of a fluorinated vitamin D analogue in hypoparathyroidism.

Several in vivo experiments have revealed that a synthesized fluorinated analogue of vitamin D, 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 (26,27-F6-1,25(OH)2D3) has a higher and longer-lasting biological activity than 1,25(OH)2D3 in calcium regulating actions. We evaluated the biological potency and the availability for clinical use of this compound in hypocalcemia associated with hypoparathyroidism. In an experimental setting, daily administration of 650 pmol/kg of 26,27-F6-1,25(OH)2D3 showed an equivalent effect to that of 3250 pmol/kg of 1,25(OH)2D3 in elevating whole blood ionized calcium levels in parathyroidectomized rats. Furthermore, an additional clinical study demonstrated that 0.5-1.5 micrograms/day of 26,27-F6-1,25(OH)2D3 were considered adequate maintenance doses in various types of hypoparathyroidism and that changes of medication to the same doses of 1,25(OH)2D3 resulted in prompt decline of urinary calcium excretion and of whole blood ionized calcium levels, and in recurrence of symptoms related to hypocalcemia. Although the mechanism responsible for the high potency of this analogue remains unclear, our experience confirms that 26,27-F6-1,25(OH)2D3 has higher biological activities in bone calcium mobilization and is more potent than 1,25(OH)2D3 in correcting hypocalcemia of hypoparathyroidism in a hospital setting.

Animals↗

Effects of vitamin D-binding proteins on HL-60 cell differentiation induced by 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D.

Monocytic differentiation-inducing activity of 26,26,26,27,27,27-hexafluoro-1 alpha,25-dihydroxyvitamin D3 [26,27-F6-1 alpha,25-(OH)2D3] was re-evaluated in human promyelocytic leukemia (HL-60) cells in serum-supplemented or serum-free culture. The order of in vitro potency for reducing nitroblue tetrazolium (NBT) was 26,27-F6-1 alpha,25-(OH)2D3 greater than 1 alpha, 25-dihydroxyvitamin D3 [1 alpha,25-(OH)2D3] = 26,26,26,27,27,27-F6-1 alpha,23(S), 25-trihydroxyvitamin D3 [26,27-F6-1 alpha,23(S), 25-(OH)3D3] under serum-supplemented culture conditions, whereas the order was 1 alpha, 25-(OH)2D3 = 26,27-F6-1 alpha,25-(OH)2D3 greater than 26,27-F6-1 alpha,23(S), 25-(OH)3D3 under serum-free culture conditions. This rank order for differentiation-inducing activity under serum-free culture conditions correlated well with the binding affinity of these analogs for vitamin D3 receptor of HL-60 cells. The order of relative % binding affinity for the vitamin D-binding protein in fetal calf serum was 1 alpha,25-(OH)2D3 (100%) much greater than 26,27-F6-1 alpha,25-(OH)2D3 (5.1%) greater than 26,27-F6-1 alpha,23(S), 25-(OH)3D3 (less than 1%). These results suggest that serum vitamin D-binding proteins apparently modulate monocytic differentiation of HL-60 cells by 26,27-F6-1 alpha,25-(OH)2D3 under serum-supplemented culture conditions.

Binding, Competitive↗

Tritium concentration in Akita City diet.

The 3H concentration in the diet of residents in Akita City, northern Japan, during autumn of 1987 and winter of 1988 was analyzed. Results were similar to those for spring and summer samples previously reported. No significant seasonal change of 3H concentration was observed. A simple model was constructed for estimating the mean residence time for organically-bound 3H in diet. However, more data about diet in the 1960s or 1970s are necessary for the estimation.

Diet↗

[Clinical and CT-findings in hemiballismus].

We studied the correlation between clinical and CT-findings in 33 cases with hemiballismus. Of these 33 cases, 4 cases were examined by the authors and 29 cases were obtained from the literature. Cerebrovascular disease was present in 27 cases and the localization of the lesion was examined with CT. Of these 10 cases had lesions in the subthalamus, while 17 cases had lesions outside the subthalamus. In 6 cases, the location of the lesion was not recognized on CT. In cases with lesions outside the subthalamus, 11 cases had lesions in the putamen, 10 cases had lesions in the caudate. Therefore the lesion were largely located in the striatum. Typical hemiballismus was seen in 16 cases. In this group, 6 cases had lesions in the subthalamus, 5 cases had lesions in the putamen, and 3 cases had lesions in the caudate. Hemiballismus accompanied by hemichorea was seen in 17 cases. In this group, while 9 cases had hemichorea with ballismus, and 5 out of 9 cases had lesions in the caudate, 4 cases had lesions in the putamen. Thus, all lesions were located in the striatum. Eight out of 17 cases had hemiballismus with chorea. In these 8 cases, 4 cases had lesions in the subthalamus, these were 2 cases in the putamen, and 2 cases had lesions in the caudate. When all cases were examined in terms of clinical manifestations, 10 cases were considered to have lesions in the caudate and 7 out of 10 cases involved chorea. Ten cases had lesions in the subthalamus, while 6 out of 10 cases showed typical hemiballismus.(ABSTRACT TRUNCATED AT 250 WORDS)

Cerebral Infarction↗

[Transcatheter arterial embolization therapy of metastatic bony tumor in hepatocellular carcinoma--a case report].

Metastatic bony tumor was found in a patient with liver metastasis of hepatocellular carcinoma, 5 years and 2 months after hepatectomy. Transcatheter arterial embolization therapy via lumbar artery was performed two times, at first with 20 mg of doxorubicin. The response was Progressive Disease by CT and bone scintigraphy, but recovery of performance status 4 to 2 was achieved in five days. In conclusion, transcatheter arterial embolization therapy may be a choice of therapy for metastatic bony tumor of hepatocellular carcinoma.

Adult↗

[A case report on the sliding commissuroplasty for mitral regurgitation due to posterior commissural chordal rupture].

We have performed a mitral valve reconstruction on a 31-year-old man who suffered from infective endocarditis four years ago. Severe mitral regurgitation and posterior commissural chordal rupture were noted. The mitral valve was repaired by Carpentier's sliding commissuroplasty and ring annuloplasty. The postoperative course was uneventful, and mitral regurgitation completely disappeared. It appears that Carpentier's sliding commissuroplasty is a superior new reconstructive technique for mitral regurgitation due to commissural chordal rupture.

Adult↗

Length of the human umbilical cord in multiple pregnancy.

The factors controlling the length of the human umbilical cord are uncertain. In the generally accepted 'tension theory', the length of the umbilical cord is proposed to increase the tensile force on it in the uterus. The greatest tensile force is supposed to be fetal movement. If this is so, the length of the umbilical cord should be shorter in multiple pregnancy than in single pregnancy. To examine this possibility we measured the umbilical cord lengths in 3314 singleton births, 82 twins births (164 infants), and 11 triplet or quadruplet births (35 infants). The cord lengths in multiple pregnancies (twins 51.3 cm, triplets and quadruplets 50.1 cm) tended to be shorter than that in singleton pregnancies (57.2 cm). However, no significant difference was found in the ratio of the umbilical cord length to the infant body weight in these groups. Therefore, we conclude that an important factor in determining the cord length is the size of the infant.

Body Weight↗

Intracranial metastasis of a choroid plexus papilloma originating in the cerebellopontine angle region: a case report.

The authors present a rare case in which a choroid plexus papilloma originating in the left cerebellopontine angle region metastasized and formed a space-occupying lesion in the right temporal region. A 46-year-old woman with choked disks presented with two separate mass lesions in the right temporal and the left cerebellopontine angle regions. Magnetic resonance imaging exhibited the relationship between the tumors and the surrounding structures. To our knowledge, no case has been reported in which a choroid plexus papilloma originating in the cerebellopontine angle region formed a space-occupying lesion in the right temporal region.

Brain Neoplasms↗

Mechanism of action of newly developed vitamin D analogue.

26,27-F6-1,25(OH)2D3 has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo, instead of almost equal binding to 1,25(OH)2D3 receptor and comparatively short serum half-life. To date, the mechanism of higher action is not known, but using these analogues as a mirror we might be able to elucidate the mechanism of action or the metabolism of the kidney hormone, 1,25(OH)2D3.

Animals↗

Tritium concentration in unpolished rice.

Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples collected from the general environment. To confirm their result, seven unpolished rice samples obtained just after harvesting were analyzed for 3H. The mean specific activity ratio of organically-bound 3H to free water 3H was found to be 0.57, somewhat lower than the data by Inoue and Iwakura. This small difference may be caused by the different sampling years and/or the possible replacement of free water by atmospheric water vapor after harvesting.

Food Contamination, Radioactive↗

[Effectiveness and timing of one shot transarterial infusion and/or transcatheter arterial embolization therapy for recurrence of postoperative hepatocellular carcinoma].

From January '81 to April '91, one shot transarterial infusion therapy and transcatheter arterial embolization therapy were performed in five patients with recurrences of hepatocellular carcinomas after surgery. The results revealed as follows: (1) Mean duration from surgery to initial arterial infusion and/or embolization therapy was 44.3 months, except one recurrence occurred in a short time. (2) The longest survival was 100 months, and mean survival was 64.8 months. One expired with multiple organ failure after arterial embolization therapy, but the others survived and could return to life in society. These results suggested that one shot transarterial infusion therapy and/or transcatheter arterial embolization therapy was effective long-term intermittent treatment for recurrence of postoperative hepatocellular carcinoma.

Adult↗