Search PubMed⌕ Search

Biomedical subjects

T Kano

Publications and source records attributed to T Kano.

At least 253 records · Page 14Linked to original sources
PubMed1983

Pharmacological effects of flurazepam and diazepam on isolated canine arteries.

The effects of flurazepam and diazepam, benzodiazepine derivatives, on contractions (or contractures) induced by Ca++, K+ or norepinephrine were examined in the isolated canine coronary artery and thoracic aorta. Ca++-Induced contraction was evoked by cumulative addition of CaCl2 to Ca++-depleted K+-depolarizing solution; K+: and norepinephrine-induced contractions were evoked by cumulative addition of KCl and norepinephrine, respectively, to the medium. Flurazepam and diazepam (1 X 10(-5), 3 X 10(-5) and 1 X 10(-4) M for coronary artery; 3 X 10(-5) and 1 X 10(-4) M for thoracic aorta) shifted the dose-response curves for KCl downwards in a non-competitive manner, and shifted the dose-response curves for CaCl2 to the right in a competitive manner. Ca++-Induced contracture was inhibited completely by addition of flurazepam or diazepam (1 X 10(-4) M), and the inhibition was reversed dose-dependently by addition of CaCl2. Flurazepam and diazepam (3 X 10(-5) and 1 X 10(-4) M) shifted the dose-response curves for norepinephrine both rightwards and downwards in the thoracic aorta. These findings suggest that flurazepam and diazepam inhibit Ca++-influx into the cells (Ca++-antagonistic effect), causing relaxation and inhibition of K+-, Ca++-, or norepinephrine-induced contraction (or contracture) of the vascular smooth muscle.

Animals↗
PubMed1983

Polymorphism of parathyroid glands in patients with chronic renal failure and secondary hyperparathyroidism.

The excised parathyroid glands of twenty-one patients with secondary hyperparathyroidism due to chronic renal failure were submitted to careful histopathologic examinations including electron-microscopy. The previous history of these patients who had been on hemodialysis treatment for a certain period was relatively uniform with no association with primary hyperparathyroidism. Although eleven patients had four evenly enlarged parathyroid glands, eight patients showed four unevenly enlarged parathyroid glands with one or two glands weighing less than 100 mg. Histopathologic patterns of hyperplasia are easily divided into two distinctly different patterns, diffuse and nodular. Thirteen cases showed the same histopathological patterns of hyperplasia, either diffuse or nodular, in all excised glands. However, one or two out of four glands in eight patients evidenced a different histopathological pattern.

Adult↗
PubMed1983

[Adjuvant chemotherapy for aged patients with gastric carcinoma].

The effectiveness of postoperative adjuvant chemotherapy on aged patients (more than 70 years old) with resectable gastric carcinoma was examined in our Department. Of the 178 patients, 75 patients received the drugs on various regimen and 103 patients had no chemotherapy a control group). No significant difference was noted in patient characteristics of age, sex and curability. In advanced gastric carcinoma such as stage III and IV, a significant increase in long-term survival after surgery was obtained with combination chemotherapy or immunochemotherapy compared with the control group (P less than 0.05). On the other hand, there was no significant difference in a survival rate of the patients with stage I and II.

Aged↗
PubMed1983

[Echocardiography of ischemic heart disease simulating dilated cardiomyopathy, with special reference to abnormal wall movement on the short-axis].

The purpose of this study was to determine whether two-dimensional echocardiography (2DE) can differentiate ischemic myocardial disease (IMD) from dilated cardiomyopathy (DCM). The subjects consisted of six cases of IMD which showed left ventricular dilatation (LVDd greater than or equal to 60 mm) and diffuse abnormality of wall motion, but did not show obvious localized myocardial infarction or left ventricular aneurysm on 2DE, and 16 cases of DCM. Two cases of IMD had previous myocardial infarction, and five cases of DCM had cardiomegaly following myocarditis. A short-axis image of the left ventricle was recorded at the chordal and the papillary muscle levels. Each image was divided into 4 segments, which were comprised of the septum, anterior wall, lateral (posterolateral) wall, and posterior (posteromedial) wall. Regional wall motion abnormality with reference to systolic thickening was analyzed qualitatively in each segment. The results were as follows: In ECG findings in IMD group, only one case showed abnormal Q waves and five cases showed left ventricular hypertrophy (LVH) similar to intraventricular conduction defect. On the other hand, in DCM group seven cases showed abnormal Q waves and five cases showed LVH. Two cases of IMD had two-vessel disease and four three-vessel disease, respectively. Left ventricular ejection fraction by cine-angiography ranged from 0.10 to 0.39 (mean 0.24) in IMD group and from 0.22 to 0.42 (mean 0.36) in DCM group. Mean LVDd showed no significant difference between these two groups. Five cases of DCM showed marked left ventricular dilatation (LVDd greater than or equal to 75 mm), but there were no such cases in IMD group. B-B' step was recognized in only one case of IMD, though it was present in eight cases in DCM. In regional wall motion, incidence of asynergy such as akinesis or dyskinesis was higher in IMD group than in DCM group. Left ventricular asynergy was more serious in the posteromedial wall than the posterolateral wall at the same image in five cases of IMD. However, in 12 cases of DCM, the degree of asynergy was equal at the both walls. In conclusion, it is recommended to examine echocardiographically the extent of severe asynergy in the posteromedial and posterolateral walls in order to differentiate IMD from DCM.

Adolescent↗
PubMed1983

[Significance of splenectomy in the treatment of cancer].

With inoculation of a large amount of tumor cells, the tumor growth of splenectomized mice was depressed compared to sham operated mice. On the contrary, with inoculation of a small amount of tumor cells the occurrence of tumor was lower in sham-operated mice. The effect of splenectomy on tumor growth was bidirectional depending on the dose of the inoculate. The effect was due to the production of the immunosuppressive factor in sera obtained from mice inoculated with a large but not small amount of tumor cells. Studies for the late survivals of 113 patients who had received curative total gastrectomy with or without splenectomy revealed that the non-splenectomized group showed a significantly better late survival rate than the splenectomized group when the splenic hilar lymph nodes were not involved with cancer metastasis.

Animals↗
PubMed1983

[A case of solitary myeloma (BJ-lambda) showing marked morphological changes].

The case report here was documented clinically, cytologically and histologically over a period of 5 years. A 49-year-old man was admitted to our hospital in September, 1975 because of a painful lump over the sternum and a diagnosis of solitary well-differentiated plasmocytoma (BJ-lambda) was made. The tumor promptly subsided following chemotherapy. In July, 1980 as it had in June, 1979, the sternal tumor relapsed; morphologically it was a poorly differentiated plasmocytoma. It promptly subsided following the start of chemotherapy and/or radiation therapy. In February, 1981, an abdominal tumor and ascites developed, morphologically it was plasma cell sarcoma composed of giant and bizarre tumor cells of plasma cell origin as demonstrated by immunoelectron microscopy. In April, 1981, the patient died of cachexia. At autopsy, multiple tumor formations consisting of giant and bizarre myeloma cells were found in the abdominal cavity, liver, retroperitoneum, diaphragm, left adrenal gland, mediastinum and lymph nodes. There was no infiltration of myeloma cells into bones other than the sternum.

Abdominal Neoplasms↗
PubMed1983

Bromocriptine therapy of luteal insufficiency accompanied with hyperprolactinemia in the follicular phase.

The therapeutic effectiveness of bromocriptine was studied in 24 patients (40 cycles) with luteal insufficiency accompanied with hyperprolactinemia in the follicular phase. Treatment with bromocriptine was started on day 5 of each menstrual cycle and continued for 7 days per cycle. In the first menstrual cycle, this 7-day treatment lowered the blood prolactin level, and significantly increased blood estradiol and progesterone in 83.3% of the patients. Among the patients whose prolactin levels were not lowered by bromocriptine, only a few showed increases in estradiol or progesterone. In many of the patients whose prolactin levels were excessively lowered to 5 ng/ml or less, progesterone was decreased. These results suggests that bromocriptine produces a favorable effect on hyperprolactinemic luteal insufficiency by secondarily stimulating progesterone secretion as a result of suppressing the follicular growth "inhibiting action of prolactin. Prolactin of an appropriate concentration, however, was considered to be needed for the maintenance of normal function of the corpus luteum.

Anovulation↗
PubMed1982

Effects of flurazepam and diazepam in isolated guinea-pig taenia coli and longitudinal muscle.

The effects of the benzodiazepine derivatives flurazepam and diazepam on K+- and Ca2+ -induced contracture were examined in isolated taenia coli and longitudinal muscle of the guinea-pig. Flurazepam and diazepam inhibited the tonic component more than the phasic component of the K+ -induced contracture of taenia coli. In longitudinal muscle, both flurazepam and diazepam inhibited the Ca2+ -induced contracture dose-dependently. These findings suggest that the observed effects of flurazepam and diazepam may have been due to inhibition of the transmembrane influx of Ca2+.

Animals↗
PubMed1982

Combined effect of prophylactic lymphadenectomy and long term combination chemotherapy for curatively resected carcinoma of the stomach.

Effectiveness of prophylactic extensive lymph node dissection (PELD) plus postoperative long term combination chemotherapy (PLCC) for patients with curatively resected gastric carcinoma was assessed in terms of the degree of serosal invasion and lymph node metastasis. Either the Group 1 and Group 2 lymph nodes were eradicated by PELD. PLCC included intermittent intravenous administration of mitomycin C (0.4 mg/kg intraoperatively followed by 0.2 mg/kg every 3 months) and oral administration of Tegafur (600-800 mg/day) and PSK (3.0 g/day), an immunostimulator, for as long a period as possible. PELD alone resulted in a cure when the malignancy was confined to the mucosal and muscular layers of the stomach as well as to the Group 1 lymph nodes. In cases when the carcinoma involved the serosa and/or the Group 2 lymph nodes, the 5 year survival rate was about 55 per cent the PELD and PLCC groups, such being significantly higher than about 27 per cent in the PELD alone group. Therefore, PELD plus PLCC is highly effective for advanced gastric carcinoma, under a condition of curative resection.

Adjuvants, Immunologic↗
PubMed1982

Postoperative long-term cancer chemotherapy (PLCC) extends life-span of non-curatively resected patients with stage IV gastric cancer.

Postoperative long-term cancer chemotherapy (PLCC) with a combination of Mitomycin-C, Tegafur and PSK (an immunostimulant) was applied to non-curatively resected cases with stage IV gastric cancer (invading the adjacent organs and/or with metastasis to the liver, peritoneum, and/or distant lymph nodes). This approach has a significant life-prolongation effect. The two-year survival rate was 16.8 per cent in the PLCC group, such being higher than 6.7 per cent and 1.7 per cent in MMC and no chemotherapy groups (p less than 0.05). 50 per cent survival periods in those with liver metastasis were 8.3 months in the PLCC group, such being longer than 5.2 and 2.8 months in MMC and no chemotherapy groups (p less than 0.002) respectively. Combination therapy of PLCC and intra-arterial infusion of 5-FU through the proper hepatic artery prescribed for 8 patients with liver metastasis resulted in a 3-month prolongation of 50 per cent survival periods, compared with PLCC alone (p less than 0.05). In those with peritoneal dissemination the rate was 10.5 months in the PLCC group, that is longer than 6.5 months in the MMC group (p less than 0.02). In cases of invasion to other organs plus distant lymph node metastasis, the time was 11.0 in PLCC and 7.0 months in MMC groups (p less than 0.05). Thus, PLCC is a palliative approach for non-curatively resected carcinoma of the stomach.

Antineoplastic Agents↗
PubMed1982

Serial determinations of carcinoembryonic antigen for early detection of recurrent gastric cancer.

In attempts to predict the recurrence of gastric cancer, postoperative changes in serum carcinoembryonic antigen (CEA) levels are monitored in our clinic by radioimmunoassay (Dainabot, Japan). Recurrences are suspected when serum CEA levels are 4 ng/ml, in the postoperative period. Out of 34 patients in whom there were increases in serum CEA, 18 were confirmed to have a recurrence and 15 of these 18 patients were assessed accurately by serial postoperative levels of CEA, two patients died of a recurrence after elevation of serum CEA levels. Thus, recurrence was predicted in 17 out of 34 patients (50 per cent) and in 12 out of 17 patients there was a metastasis to the liver. In 14 out of 34 patients there are no signs of recurrence 9 to 25 months after serum CEA elevations.

Adenocarcinoma↗
PubMed1982

Association between the MB system and asthma in the Japanese.

Twenty-three unrelated Japanese patients with asthma who showed a high total serum IgE level, a strong skin test response to Dermatophagoides farinae, and a high score on a radioallergosorbent test (RAST) using Dermatophagoides farinae were typed for HLA-A locus, -B locus, and -D region antigens. No significant difference in the frequencies of HLA-A, -B, and -DR antigens were observed between the asthma patients and the healthy controls. A significant difference in the frequency of MB3', however, was found between the asthma patients and the healthy controls (corrected p = 0.04, relative risk = 18.5).

Asthma↗
PubMed1982

Effects of estrogen and progesterone on adrenoceptors and cyclic nucleotides in rat uterus.

The effects of estrogen and progesterone on adrenoceptors and cyclic nucleotides were studied in ovariectomized rat uterus. The effects on adrenoceptors were examined by measuring mechanical responses to noradrenaline and by binding site determinations with [3H]-dihydroergocryptine and [3H]-dihydroalprenolol. After acute administration of estradiol-17 beta, uterine cyclic GMP was progressively and significantly elevated, but cyclic AMP declined through it was not significant. Phentolamine suppressed this cyclic GMP elevation. Both acute and chronic treatments with estrogen increased the number of alpha-receptors. The increase in uterine cyclic GMP was related to the increase in alpha-stimulation as a result of increased alpha-receptors. Chronic treatment with estrogen increased the number of alpha-receptors. The alpha-effect induced by noradrenaline was bidirectional in the uterus treated with estrogen chronically; there was contraction in normal Tyrode's solution and relaxation in high K+ Tyrode's solution. In other hormonal group, either alpha- or beta-effects produced relaxation. Enhancement of the alpha- and beta-effects by estrogen is attributed to an increased number of the receptors. Acute treatment with estrogen decreased the responses of cyclic AMP to isoproterenol and mechanical reactivity. Progesterone also enhanced the beta-effect as a result of an increase in the number of beta-receptors.

Animals↗