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Biomedical subjects

T Kamo

Publications and source records attributed to T Kamo.

43 records · Page 3Linked to original sources
PubMed1982

Effect of peptide extracted from skeletal muscles of the fur seal on periodontal diseases.

It has been confirmed previously that a physiologically active peptide extracted from the skeletal muscles of fur seals exhibits excellent dermal absorption and has peripheral vasodilating properties. These properties were postulated to be beneficial to inflamed periodontal tissues. To test this, a dentifrice containing the peptide was prepared and utilized in a double-blind test. Significant improvement in the gingiva conditions was observed when a 0.1% or more concentration of peptide was used. As time progressed, distinct clinical improvement in redness, swelling, drainage, bleeding and pocket depth was noted. No significant side effects were noted although there were seen increased salivation and gingival blanching. It is believed, as a result of this and other studies, that the clinical efficacy of this peptide is due to its vasodilating action on the venules, thus reducing the internal pressure in the vascular beds.

Adolescent↗
PubMedDate not supplied

Subjective experience and related symptoms in schizophrenia.

We had previously extracted two types of subjective experience of schizophrenia (SES); first, a feeling of inadequacy in stream of speech, thought, and action, associated with a distorted sense of self, and second, a feeling that excessive thoughts are filling and sticking to one's head, causing negative affective burden such as misery and oppression. This study tried to validate their content using conventional symptom clusters as external validators. Subjects were 63 patients from two hospitals in Tokyo meeting ICD-10 criteria for schizophrenia. Positive, negative, and depressive psychopathology were measured by the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of the Negative Symptoms (SANS), and Hamilton's Depression Scale (HDS). The two types of SES were measured by an original scale. The first type of SES correlated significantly with the negative symptoms of alogia, avolition, and attention, whereas the second correlated with positive and depressive symptoms. To analyze how schizophrenia is experienced by patients, qualitative and comprehensive descriptions, such as indicated by our subjective factors, will be useful.

Adult↗
PubMedDate not supplied

Insight and clinical correlates in schizophrenia.

It is not clear to what extent poor insight is inherent in schizophrenic psychopathology or is related to clinical factors. It is clinically important to elucidate this point to know how some insight remains intact in schizophrenia. Sixty-three ICD-10 schizophrenics were recruited. Insight was measured by David's three-dimensional scale, which deals with the awareness of the need for treatment, of the illness, and of psychotic experiences. Clinical factors that may influence insight were grouped into objective psychopathology, subjective experience, and treatment settings, according to the normal development of insight starting from objective illness, through subjective perception of it, to seeking treatment. Psychopathology was measured by the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Negative Symptoms (SANS), and the subjective experience was measured by a checklist of our own. Positive symptoms, especially disordered thought, hallucinations, and delusions, had a modest inverse correlation with awareness of illness and of psychotic experiences, but these were not correlated with alogia or other negative symptoms. Later age at the first onset was significantly correlated with poor awareness of psychotic experience, but no correlation of subjective experience with insight emerged. Awareness of the need for treatment was significantly higher in outpatient than in inpatient groups, and was not correlated with any other variables. Poor awareness of illness and of psychotic experience seems to be a trait of the acute rather than the chronic psychopathology of schizophrenia. Poor awareness of psychotic experience was related to later onset. Awareness of the need for treatment seems to improve, even in the absence of awareness of illness or of psychotic experience, in outpatient settings--the effects of social interaction may be relevant to this.

Adult↗
PubMedDate not supplied

Cerebral angiography and ultrasonic quantitative flow measurement of common carotid artery in patients with cerebral infarction.

Blood flow rate and velocity in the common carotid artery were measured with an ultrasonic quantitative flow measurement (QFM) system and cerebral angiography was performed in 98 patients about four weeks after the onset of cerebral infarction. Angiography revealed complete occlusion in 13 patients (CO group), visible stenosis in 45 patients (S group), and no apparent stenosis in 40 patients (N group). In the CO group, damaged-side blood flow (DF; 4.80 ml/sec) and velocity (DV; 10.5 cm/sec) were significantly lower (P less than 0.01) than intact-side blood flow (7.19 ml/sec) and velocity (14.86 cm/sec). Both DF and DV were significantly lower in group CO than group S (7.55 ml/sec and 15.04 cm/sec) and in group S than group N (9.32 ml/sec and 18.07 cm/sec). Degree of stenosis in the internal carotid and middle cerebral arteries was significantly associated with reduced DF (P less than 0.05). Of the 24 patients with a mean DF of under 6.5 ml/sec, 15 had stenosis of 75% or more; of the 74 patients with a mean DF of 6.5 ml/sec or more, 66 had stenosis of less than 25%. The results indicate that blood flow determined by QFM reflects the degree of occlusion or stenosis in the intracranial trunk arteries and may thus provide a practical, noninvasive method of assessing the severity of cerebrovascular lesions.

Acute Disease↗