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Biomedical subjects

T Kamada

Publications and source records attributed to T Kamada.

At least 829 records · Page 46Linked to original sources
PubMed1977

Gastrointestinal bleeding following head injury: a clinical study of 433 cases.

The incidence of gastrointestinal bleeding was studied in 433 patients with head injury. This complication has a strong correlation to the severity of the injury. Other factors such as shock, arterial pO2 and glucocorticoid administration were not related to incidence of gastrointestinal bleeding. Forty per cent of patients developed bleeding within 48 hours and approximately and additional 40% within one week. Only nine patients required more than 1,000 ml of blood, and eight of these died and one requiring emergency abdominal surgery lived.

Adolescent↗
PubMed1977

Acute gastroduodenal lesions in head injury. An endoscopic study.

Early and serial endoscopic examinations were performed in patients with head injury to determine the actual incidence and course of the acute gastroduodenal lesions. Acute gastroduodenal lesions were found in high incidence of 35 in 47 patients (75%). It was stressed that the lesions were found in 16 of 25 cases without obvious gastrointestinal bleeding. The lesions were mainly found in the stomach (78%) and of these lesions erosive gastritis was seen in the greatest frequency. Gastric ulcer was found in 11 patients. Erosive gastritis was found within one week after the trauma, while gastric ulcer usually developed after one week. Erosive gastritis was mainly located in the body of the stomach and usually healed within ten days. Gastric ulcer also had a good course. There was no case in which the erosive lesion extended to the ulcer. Among 22 patients with gastrointestinal bleeding, three had intractable bleeding. Steroid administration seemed to have little effect on the occurrence of acute gastroduodenal lesions.

Adolescent↗
PubMed1976

An abnormal ratio of cytochromes in the respiratory chain of mouse and human myelomas.

Mouse myeloma cells and mitochondria had the same kinds of cytochrome components in the respiratory chain as the normal ones. Their constitution, however, was abnormally different from that found in normal cells and mitochondria. The cytochrome aa3 concentration was especially low in the myeloma as compared with cytochrome c concentration, and the resulting cytochrome aa3/c ratio was 0.25, which was the lowest ever reported in animal mitochondria. Normal lymph node cells, producing the immunoglobulin similar to the myeloma cells, had a ratio of 1.1. Human myeloma mitochondria had the same characteristics as the mouse myeloma. Ascite form myeloma originated from mouse solid from myeloma grew faster, and yet aa3/c of 0.5 in the ascites myeloma was found to be quite similar to that observed in various ascites tumor cells such as hepatomas, Ehrlich and sarcoma 180. A significant part of the cytochromes in the respiratory chain of the mouse myeloma remained in the oxidized form in the cyanide-inhibited or anaerobic states, and was reduced only by the addition of dithionite. The properties of the b cytochromes in mouse myeloma mitochondria are also described and discussed in the context of multiple forms of the b cytochromes in the respiratory chain.

Anaerobiosis↗
PubMed1976

Preferential phosphorylation of NP-protein of influenza A2 virus by virion-associated protein kinase.

Influenza A2 virions were found to contain protein kinase activity which was stimulated, like in other virion-associated kinases, with Mg++ and Nonidet-P 40 but not with cyclic AMP. The kinase phosphorylated only the NP-protein fraction of the influenza virions in the in vitro reaction. In contrast, none of the influenza virion proteins were phosphorylated significantly during the process of virus production in infected chorioallantoic membranes. The in vitro and in vivo phosphorylations of influenza viral proteins were compared with those of Sendai virus (HVJ).

Animals↗
PubMed1976

Endoscopic observation of the gastric mucus in vivo stained with azure A.

Gastric mucus was stained with Azure A, a cationic dye, which had the highest affinity with macromolecular constituents of the mucus, under such conditions as 0.2% Azure A-0.5% NaHCO3 solution (pH 8.1) in dye concentration, staining for ten minutes, 37 degrees C in reaction temperature and the salt concentration and ionic strength below 6.0 x 10(-2). In rat and resected human stomachs, gastric mucus was clearly stained under these conditions. In human subjects, the in vivo stained muscu was observed endoscopically. The pyloric gland region. The difference was seen in the pattern of the gastric area between the fundic and pyloric gland region. Histological examination revealed that only the mucous layer was stained with Azure A. The stained macromolecules in the mucus and factors affecting the staining were discussed.

Adolescent↗
PubMed1975

"Trench ulcer" of the stomach.

The clinical, endoscopic and histological findings of 14 cases with unusual gigantic ulcers of the stomach were reported. The patients were mainly aged, complicated by cardiovascular diseases. The ulcer was designated as "trench ulcer" from the characteristic endoscopic features, which ran from the cardiac portion to the angle along the lesser curvature.

Adult↗
PubMed1975

Dynamic studies on the portal hemodynamics of scintiphotosplenoportography. Streamline flow in the human portal vein.

To demonstrate streamline flow in the human portal vein, the hepatic lobar distribution of splenic flow was studied in 6 patients without liver disease and 4 patients with chronic hepatitis using a new technique, scintiphotosplenoportography, followed by 198Au-colloid liver scintigraphy. In two patients, a 99mTcO4-bolus injected into the spleen drained predominantly into the left lobe of the liver. A repeat examination performed in one patient revealed that the bolus was chiefly directed to the other lobe, the right lobe. In 3 patients, the distribution of 99mTcO4- radioactivity was the same as that observed with 198Au-colloid. In the other 5 patients the predominant distribution of 99mTcO4- was observed in the right lobe. In 8 of 11 studies, splenic flow was distributed either to the right or left lobe instead of diffusely to both lobes. This result suggests that flow in the human portal vein is streamline rather than turbulent.

Adult↗