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Biomedical subjects

T Kamada

Publications and source records attributed to T Kamada.

At least 811 records · Page 45Linked to original sources
PubMed1978

Oxidative and phosphorylative activities of the gastric mucosa of animals and humans in relation to the mechanism of stress ulcer.

In order to elucidate the mechanism of stress ulceration, which is mainly involved with the corpus mucosa of the stomach, the aerobic energy metabolism of the corpus mucosa of rats, rabbits and humans was investigated and compared with those of the antral mucosa as well as other organs such as heart, kidney and liver. The results showed that the activities of respiration and oxidative phosphorylation and the concentration of the respiratory chain components were far greater in the corpus mucosa than in the antral mucosa, the activities in the former being almost equal to that of the highly aerobic tissue, kidney cortex. Furthermore, the endogenous respiratory rate (in the absence of added substrate) was also much higher in the corpus mucosa than in the antral mucosa, indicating that oxygen demand at resting state (during the period of H+ secretion) is also higher in the corpus mucosa. We conclude that in the corpus mucosa of the stomach the aerobic energy metabolism is predominant. It is suggested that circulatory insufficiency may easily result in cell damage mainly of the corpus mucosa due to energy deficit.

Animals↗
PubMed1978

Cadmium toxicity and liver mitochondria. I. Different effects of cadmium administered in vivo to adult, young, and ethionine-fed rats.

The changes in liver mitochondrial respiratory activities and cytochrome concentrations were investigated when cadmium chloride was administered orally to adult, young, and ethionine-fed rats. Following a seven-day administration of 30 ppm cadmium in drinking water, adult rats showed no change, while young rats and ethionine-fed rats exhibited a marked increase in mitochondrial respiration with concomitant decrease of respiratory control index and P/O ratio. The concentrations of cytochromes aa3, b, and c + c1 in liver mitochondria were unchanged in adult rats, but increased significantly in ethionine-fed rats. In young rats receiving cadmium the liver mitochondrial protein increased with a slight change in the cytochrome concentration in mitochondria. It was further found that in adult rats a higher concentration (300 ppm) of cadmium in drinking water was toxic to the liver mitochondrial functions. Thus, the effect of oral administration of cadmium on the liver mitochondrial function depends on the condition of the animals.

Aging↗
PubMed1978

Measurement of regional hepatic blood flow by scintiphotosplenoportography.

A new technique for estimating regional hepatic blood flow using the inert gas washout technique and scintillation camera following injection of 133Xe into the spleen is presented. This technique is easily, rapidly and repeatedly performed and permits the measurement of nutrient hepatic tissue blood flow. Measurement of regional hepatic blood flow in right and/or left lobes was performed in 28 patients. In all but one patient the right lobar flow value was equal to or greater than the left one. The right lobar flow was 86.20 +/- 12.83 ml/100 gm/min in 3 patients without liver disease, 75.12 +/- 14.54 ml/100 gm/min in 12 with chronic hepatitis and 51.24 +/- 17.13 ml/100 gm/min in 11 with liver cirrhosis. This result suggests that hepatic tissue blood flow is significantly decreased in patients with liver cirrhosis. Scintillation camera images of initial xenon distribution in combination with monitor of washout curves over the liver also provide more informations on the presence of extra-and intrahepatic shunts. Therefore, this technique appears to be clinically useful in evaluation of hemodynamic phenomena associated with liver diseases.

Collateral Circulation↗
PubMed1977

Simultaneous measurement of mitochondrial and microsomal cytochrome levels in human liver biopsy.

The mitochondrial and microsomal cytochromes in patients' livers obtained from needle biopsies have been analyzed using a sensitive spectrophotometric method. To determine simultaneously the concentration of these cytochromes from hemoglobin-contaminated liver, difference spectra of liver homogenates were taken at the temperature of liquid nitrogen before and after photolysis of carbon monoxide molecules from various hemoprotein-CO complexes. This method utilizes a characteristic property of hemoprotein-CO complexes, in which the reassociation of CO molecules with photolyzed hemoglobin, cytochrome P-450 and cytochrome alpha3 is temperature-dependent. The results in 69 cases with a variety of liver diseases have revealed that the concentrations of cytochromes alphaalpha3, P-450 and beta5 showed a huge variation in the injured livers as compared with those in the normal controls. The significance of the measurement of these cytochrome concentrations and their ratios is discussed.

Biopsy↗
PubMed1977

Carcinoembryonic antigen, alpha-fetoprotein and carcinoplacental alkaline phosphatase in gastric carcinoma metastatic to the liver.

Carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and carcinoplacental alkaline phosphatase (CPALP) were detected simultaneously in the sera and body fluids of two male patients with gastric carcinoma matestatic to the liver. At autopsy, widely disseminated gastric cancer of Borrmann III type with liver metastases was revealed in both bases. Histologically, they were moderately differentiated tubular and papillary adenocarcinomas with marked cellular atypia and necrosis. In Case 1, the properties of CPALP were identical to Nagao type CPALP, and in Case 2 the Variant type CPALP. Using immunofluorescence, CEA and CPALP were demonstrated in both primary and metastatic cells. However, only in Case 2 was AFP observed in some of the primary tumor cells.

Adenocarcinoma, Papillary↗