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Biomedical subjects

T K Chatterjee

Publications and source records attributed to T K Chatterjee.

At least 55 records · Page 3Linked to original sources
PubMed1983

Effects of chloroquine on lysosomal enzymes, NADPH-induced lipid peroxidation, and antioxidant enzymes of rat retina.

Chloroquine (1, 5 and 10 mg/kg), given in acute and in chronic (7 and 15 days) treatment schedules, caused characteristic alterations in the lysosomal enzyme system, antioxidant enzymes, NADPH-induced lipid peroxidation, and glutathione content in the retina of the rat. One-half hour and four hours after chloroquine administration, increased free activities of lysosomal enzymes and NADPH-induced lipid peroxidation were observed, associated with a decrease in tissue glutathione content. In contrast to the acute effect, chloroquine, given in 7- and 15-day treatment schedules, had no significant effect on the lysosomal enzyme system, while at the same time a normalization or a decrease in NADPH-induced lipid peroxidation, associated with a significant increase in tissue glutathione content, was noted. Catalase and peroxidase activities were decreased after both the acute and the daily treatment schedules. Superoxide dismutase activity, although increased in the high dose acute study, appeared otherwise little affected by chloroquine treatment.

Acetylglucosaminidase↗
PubMed1983

Modification of morphine antinociceptive response by blood glucose status: possible involvement of cellular energetics.

The antinociceptive response to morphine was enhanced in insulin-hypoglycemic animals whereas it was decreased in diabetic or in hypertonic glucose-pretreated hyperglycemic animals. 3-O-Methylglucose was, however, without effect on morphine analgesia whereas 2-deoxyglucose sensitized this effect. Furthermore, as malate and isocitrate attenuated the morphine analgesic response of insulin hypoglycemic animals and 2,4-dinitrophenol sensitized this response in diabetic animals, it is possible that the blood glucose level affects the morphine analgesic response by affecting cellular energetics.

Analgesia↗
PubMed1982

Adrenal involvement in captopril-induced potentiation of morphine analgesia.

The involvement of the angiotensin-adrenal system as a possible mechanism in the potentiation of morphine analgesia by the angiotensin-converting enzyme inhibitor, captopril (SQ 14225), was studied in rats. Captopril pretreatment sensitized the animals to the analgesic effects of morphine while angiotensin II exerted an attenuating influence. These effects, however, were not demonstrable in adrenalectomized animals. Although captopril could inhibit the plasma angiotensin-converting enzyme activity, it appeared to have no significant effect on the brain enzyme. It has been suggested that the effects of captopril and angiotensin II on morphine analgesia are mediated indirectly through their effects on adrenal function.

Adrenal Glands↗
PubMed1982

Possible physiological role of adrenal and gonadal steroids in morphine analgesia.

The effects of adrenal and gonadal steroids on the antinociceptive potency of parenteral morphine were studied in male rats. At all doses studied, dexamethasone pretreatment 30 min before morphine sensitized the animals to the effects of parenteral morphine. However, at higher doses of dexamethasone this sensitization was masked when dexamethasone was given 4 h before morphine by a cycloheximide-sensitive attenuating effect. This feature is not a specific glucocorticoid effect since testosterone showed similar characteristics. Estradiol-17beta and progesterone, however, produced only a cycloheximide-sensitive attenuating response at 4 h. Deoxycorticosterone on the contrary had a cycloheximide-independent attenuating influence with both pretreatment schedules. Results of the present study indicate that morphine subsensitivity after castration or supersensitivity after adrenalectomy may be attributed to the relative lack of testosterone or mineralocorticoid in the respective conditions. Furthermore, in view of the fact that testosterone plays a rate-limiting role in determining the morphine sensitivity of the animals and that mineralocorticoids exert their effects indirectly via antagonism of testosterone action.

Adrenalectomy↗
PubMed1981

Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats.

In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of (i) DNA, RNA and protein content, (ii) the tartrate-insensitive form of acid phosphatase, and (iii) the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. These results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.

Acid Phosphatase↗
PubMed1980

Gonococcal infection in women with pelvic inflammatory disease in Lusaka, Zambia.

Gonococcal infection is the most common disease in both male and female patients seen at the Sexually Transmitted Disease Clinic at the University Teaching Hospital in Lusaka, the capital city of Zambia. In this study, 100 women admitted to the gynecology wards for management of pelvic inflammatory disease were screened for gonococcal infection using an endocervical culture on modified Thayer-Martin medium. Forty-six of these women had gonococcal infection, including 65% of those women with PID of less than 2 weeks' duration. Because gonorrhea is so common among women with PID, "standard" antibiotic regimens must be reevaluated. We recommend for countries with a high incidence of gonorrhea that initial treatment of PID should include an antibiotic regimen effective for gonococcal infection.

Adolescent↗
PubMed1978

Surface model of the collagen fibril as determined by two-stage plastic replica.

Two-stage plastic replicas of fresh and vacuum dried rat tail collagen were examined by electron microscopy. Microphotometer tracings made from the replica micrographs showed that the surface of the collagen has a periodic undulating topography which includes an approximately 20--40 A deep depression located within the major band distance.

Animals↗
PubMed1978

Preoperative cervical dilatation with 15(S)15-methyl PGF2alpha methyl ester pessaries.

A clinical trial comparing two vaginal dose schedules of 15(S)15-methyl prostaglandin F2alpha (PGF2alpha) methyl ester (4 or 6 mg) for preoperative dilatation of the cervix is described. The trial included 28 patients at 8-12 weeks' gestation. Vaginal pessaries containing either 1.0 mg (15 patients) or 1.5 mg (13 patients) of the prostaglandin analogue were administered every 3 hours (maximum, 4 doses). The success rates for the two groups were 93% and 100%, respectively. Sixty percent of the patients aborted before the planned vacuum aspiration. Minor side effects, primarily vomiting and diarrhea, occurred in approximately 80% of the cases and were more prominent with the higher dose pessary. It is concluded that the vaginal administration of 15(S)15-methyl PGF2alpha methyl ester is highly effective for preoperative dilatation of the cervix before suction curettage abortion.

Abortion, Therapeutic↗
PubMedDate not supplied

Second trimester abortion with prostaglandin F2 alpha.

A clinical trial comparing 40-mg and 50-mg, intraamniotic dose schedules of prostaglandin F2 alpha (PGF2 alpha) is described. The trial included 48 patients at 15-20 weeks' gestation, with 20 receiving a 40-mg dose of PGF2 alpha and 28 receiving a 50-mg dose of PGF2 alpha. The success rates for the two groups were 85% and 93%, respectively. All nulliparous patients who had 50 mg of PGF2 alpha and all multiparous patients who had 40 mg of PGF2 alpha aborted within the 48-hour trial period. The mean induction-to-abortion interval with the 50-mg dose was two hours shorter than that with the 40-mg dose. All patients who had 40 mg of PGF2 alpha over 16 weeks' gestation aborted within the trial period. In patients who had 50 mg of PGF2 alpha, the period of gestation did not influence the induction-to-abortion interval. Minor side effects, primarily vomiting or diarrhea, were observed in 65% and 93% of the patients who had 40-mg and 50-mg doses, respectively. We conclude that intraamniotic administration of 50 mg of PGF2 alpha successfully induces midtrimester abortion in nulliparous patients, whereas a 40-mg dose suffices for multiparous women.

Abortion, Induced↗
PubMedDate not supplied

Studies on beta-endorphin and membrane-bound calcium interaction using chlorotetracycline (CTC) as a fluorescence probe.

Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mitochondria. It seems that the binding pattern or interaction of beta-endorphin with synaptosomes and erythrocytes are characteristically different from that of mitochondria, indicating some functional significance of this differential interaction.

Animals↗
PubMedDate not supplied

Tubo-ovarian abscess: a review of 46 cases.

Forty-six patients with tubo-ovarian ascess are analysed. The abscess developed mostly in young multiparous women soon after menstruation. Coliforms were the main causative organism. The abscess resolved with conservative management in 21 cases and surgical intervention was necessary in 25. The mortality (4.4%) due to conservative medical and surgical management was nearly half that of radical surgery.

Abscess↗