Pharmacokinetics: first order or zero order.
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Biomedical subjects
Publications and source records attributed to T Juszkiewicz.
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In two experiments, hens received 200 (group I) or 100 ppm of DDT per day and per kg of live weight (group II), for 17 or 10 days resp. The eggs of experimental hens were collected, and a 3 or 6 day collection of eggs was used for preparing a sample of pooled egg yolks; one part of this sample was used for preparation of a 25% egg yolk-citrate diluent, the other for DDT determination. The egg yolks of experimentally poisoned hens contained 12 to 957 ppm of DDT (egg yolks of controls 1-4 ppm) in consecutive collection samples. However, the survival time and survival indexes of bull semen (90 ejaculates) preserved at 3 degrees C and 46 degrees C in yolk citrate diluent containing DDT poluted egg yolk did not differ from those preserved in control diluter.
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A total of 1120 grain samples of oats, wheat, rye, barley, and maize, delivered for processing of mixed feeds for animals, were collected during the years 1975 to 1979 from commercial feed mills located throughout Poland. In addition, 625 samples of the commercially mixed feeds and protein concentrates were collected during 1976. For the mycotoxin survey, 751 laboratory samples were chosen at random and analyzed. When applying confirmatory tests neither aflatoxins B1, B2, G1, G2 nor sterigmatocystin, zearalenone, or ochratoxin B were found to be present in any of the samples of barley, wheat, rye, or oats. Aflatoxins were detected in about 4% of the maize samples. The presence of ochratoxin A in the range of 2 to 200 micrograms/kg was evident in 9% of the grain samples. The commercially mixed feeds were found to be more contaminated with mycotoxins than were the grains. The aflatoxins were confirmed in about 13% of the samples of mixed feeds. After the preliminary multimycotoxin analysis, out of 42 feed samples that could be suspected of containing ochratoxins, 32 failed to prove their presence. Similarly, out of 27 suspected feed samples, zearalenone was found only in one (0.5%) sample. The lowest percentage of samples contaminated with mycotoxins was found in poultry mixed feeds (4%). The highest contamination occurred among the samples of swine rations, where 17% of the samples contained aflatoxins and 13% ochratoxins. The protein concentrates contained only aflatoxins. Out of 31 analyzed samples, aflatoxins were detected in 19 (61%) in concentrations ranging from 5 micrograms/kg to 500 micrograms/kg. In one sample, aflatoxin concentration (B1 + B2) reached 1140 micrograms/kg. Practical implications of the results are discussed in relation to animal and human safety.
Laying Japanese quail (Coturnix coturnix japonica) were given single oral doses of 0, 1, 5, and 20 mg of ochratoxin A (OA) per kg of the body weight. After 6, 12, and 24 hours and 2, 3, 4, 5, 6, and 7 days an appropriate number of birds was sacrificed and OA in blood, muscles, liver, kidney, abdominal yolks, and collected eggs was measured. The highest concentration of OA was found in kidneys and the lowest in muscles. Four days following the application, OA could still be detected in kidney, liver, muscles, yolk, and eggs, although even after six days traces of OA were found in the muscles of birds given 20 mg/kg.
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