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Biomedical subjects

T Juszkiewicz

Publications and source records attributed to T Juszkiewicz.

At least 19 recordsLinked to original sources
PubMed1993

Studies on the embryotoxic and teratogenic effects of Tołpa Peat Preparation.

Neither embryotoxic nor teratogenic effects were observed in hamsters and rats after administration of Tołpa Peat Preparation (TPP) in doses of 5 and 50 mg/kg daily. Some maternal toxicity in rats and some embryotoxic effect in hamsters were recorded after the highest dose of TPP (250 mg/kg daily).

Abnormalities, Drug-Induced↗
PubMed1992

Teratological evaluation of Ukrain in hamsters and rats.

The compound Ukrain, containing thiophosphoric acid alkaloid derivatives from the plant Chelidonium majus L., was given intramusculary (i.m.) on days 6-11 of gestation to hamsters and on days 6-15 of gestation to rats in doses of 0.1, 1.67 and 28 mg/kg daily. No clinical signs of toxicity were found in treated animals and no teratogenic effect could be noted in either species. Such parameters as the number of corpora lutea, implantation sites, pre and post-implantation losses, number of live foetuses per litter, placental weight, foetal weight and crown-rump length were not significantly different between the Ukrain treated rats and the controls. Slight embryotoxic effects (increased post-implantation losses) and in consequence decreased number of average litter size were noted in hamsters exposed to Ukrain at doses which were otherwise not embryotoxic to rats.

Alkaloids↗
PubMed1990

[Usefulness of male golden hamsters for experimental reproductive pathology].

Seventy two male Golden hamsters were maintained in normal laboratory conditions (12h light-dark cycle, 20 +/- 2 degrees C) for the annual cycle experiment. Every month 6 animals were sacrificed and testis weight, cauda epididymis weight, caudal sperm number, sperm morphology and body weight were determined. The period of high gonadal activity was found to be from March to the end of July. In September reproductive activity decreased and the low activity period, with azoospermia in some animals, lasted till the end of January. This annual reproductive cycle, shown for the male Golden hamsters, should be taken into consideration when designing new experiments and interpreting their results.

Animals↗
PubMed1990

Zinc status in women with premature rupture of membranes at term.

Zinc concentrations were measured by atomic absorption spectrometry in whole blood, scalp hair, pubic hair, and colostrum from patients at term with and without premature rupture of membranes (PROM). A maternal zinc index was established for each patient, expressed as an average ranking of the four determinations. The mean +/- SD value of the maternal zinc index in patients with PROM was significantly lower than in patients without this complication (4.33 +/- 1.18 versus 5.97 +/- 1.39, respectively; P = .0002). The inverse relationship between maternal zinc index and parity was statistically significant (r = -0.61; P = .04). These results suggest that the subnormal tissue zinc content in pregnancy may play a role as a causative factor in PROM at term.

Adult↗
PubMed1987

Women in dental surgeries: reproductive hazards in occupational exposure to metallic mercury.

Eighty-one women (45 dentists and 36 dental assistants) occupationally exposed to metallic mercury underwent a toxicoclinical examination. Total mercury lebels (TMLs) were determined in scalp and pubic hair by cold vapour AAS. Furthermore a detailed questionnaire study was made concerning adverse reproductive events. TMLs in the hair of the exposed women examined exceeded significantly those determined in the hair of 34 controls not exposed to mercury. All exposed women had continued working during pregnancy. There was a significant, positive association between TMLs in the hair of exposed women and the occurrence of reproductive failures in their history. The relation between TMLs in the scalp hair and the prevalence of menstrual cycle disorders was statistically significant. These findings indicate that dental work could be another occupational hazard with respect to reproductive processes.

Abnormalities, Drug-Induced↗
PubMed1986

Hair trace metal concentration of pregnant women at term in comparison with blood and milk levels.

The concentrations of Fe, Cu, Zn and Pb were determined by means of AAS in the scalp hair (SH) and pubic hair (PH) as well as in maternal blood (MB), breast milk (BM) and cord blood (CB) taken from 104 pregnant women and their neonates. SH values of all studied metals correlated with strong statistical significance with their PH levels. Significant correlations were found between maternal Fe-PH and neonatal body length (r = 0.271) as well as between Fe-SH and placental weight (r = 0.168). The age of examined women was found to correlate negatively with Cu-SH values as well as with Zn-SH (P less than 0.05). The inverse relationship between Zn-PH and the parity of examined women was established to be statistically significant (P less than 0.001). The usefulness of hair analyses in assessing trace metal status of a pregnant woman is discussed.

Adolescent↗
PubMed1980

Occurrence and formation of nitrosamines in animal feeds.

A total of 465 samples of ingredients of animal feeds (fish meal, antarctic krill meal, experimental silage containing 40% dried animal wastes) and complete mixed feeds and protein concentrates were analysed for nitrate and nitrite content in the period 1973-78. Over 62% of the samples contained nitrates in concentrations ranging from 1 to 1020 mg/kg, and 6% contained 1-15 mg/kg of nitrites. After a preliminary survey, the samples having the highest levels of nitrate, nitrite and amines were selected and analysed for volatile N-nitrosamines. Of 171 selected samples, 40% were found to contain N-nitrosodimethylamine in the range of 0.003 to 0.417 mg/kg. No statistically confirmed correlation between concentrations of nitrates or nitrites and nitrosamines could be demonstrated. Large amounts of dimethylamine, ranging from 110 to 1765 mg/kg, were found in all samples of krill meal. Incubation of krill meal and fish meal with nitrite, under conditions similar to those existing in the animal stomach, resulted in the formation of substantial amounts of NDMA. The occurrence of N-nitrosamines in feeds and their possible formation in vivo from precursors present in feeds seems to be an important problem from the hygienic standpoint, because of possible "carry-over" to tissues, milk and eggs.

Animal Feed↗
PubMed1978

Absorption, tissue deposition and passage into eggs of N-nitrosodimethylamine in hens.

The experiments were performed on 262 laying hens divided into 8 groups: 5 groups of hens were given orally N-nitrosodimethylamine (NDMA) in single doses of 30, 10, 3, 1 and 0.1 mg/kg of body weight, two groups received tap water containing 2 and 5 mg NDMA/kg, provided ad libitum for 20 consecutive days, and one group of layers served as a control. Birds were selected at random and sacrificed at one or two day intervals and NDMA content was determined in blood, muscles, liver, brain and in collected eggs. The highest concentrations of NDMA were found 24-36 hours after dosing in all investigated tissues and eggs. A single oral dose of 0.1 mg NDMA/kg produced tissue levels up to 0.06 mg/kg and resulted in excretion of detectable amounts of the carcinogen in eggs for up to 6 days. After large doses, 10 mg and 30 mg NDMA/kg, concentrations in corresponding tissues reached 6.0 and 12.7 mg/kg, and the presence of NDMA in eggs could still be detected after 12 and 14 days. Birds receiving NDMA in drinking water showed increasing NDMA concentrations in all analysed tissue and eggs. After 12 days, the highest levels were found in eggs, blood and brain. Practical implications of the results must be evaluated from the point of view of human safety.

Animals↗
PubMed1977

Mycotoxins in grain for animal feeds.

A total of 302 crushed grain samples of barley, wheat, rye, corn and oats from the crop year 1974 were collected from commercial feed processing plants situated in all the provinces (voivodeships) of Poland. For the mycotoxin survey, performed according to the multimycotoxin detection method by Stoloff et al (1971), 150 grain samples were taken. The positive samples were analysed thereafter by the procedures for the individual mycotoxins and chemical confirmatory tests. Of the 150 samples tested by the multimycotoxin detection method, 77 (51 p. 100) showed fluorescing spots and Rf values of aflatoxins, 24 (16 p. 100) were of ochratoxins, 11 (7 p. 100) of zearalenone and 5 (3 p. 100) of sterigmatocystin. However when these samples were assayed by the specific methods and confirmatory procedures, only 8 (5 p. 100) samples were found to be positive, containing ochratoxin A at the level ranging from 50 to 200 microgram/kg.

Animal Feed↗