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Biomedical subjects

T James

Publications and source records attributed to T James.

At least 109 records · Page 6Linked to original sources

Curiosa paediatrica V: Inverted nipples.

Inverted, retracted or indrawn nipples are established in very early infancy, perhaps even prenatally, and are to be regarded as a developmental mammary malformation which is not corrigible by any manipulation. This fact should be recognized by parents and by antenatal supervisors who are consulted or called upon to advise about breast-feeding.

Breast↗

Curiosa paediatrica IV: Tortipenis congenitus.

Medical dictionaries have not yet admitted this most rare congenital anatomical deviation, for which the term torsion of the penis has been used. Tortipenis, a neoterism, should be included after tortipelvis.

Child↗

Five human tumour cell lines derived from a primary squamous carcinoma of the tongue, two subsequent local recurrences and two nodal metastases.

Five tumour cell lines have been derived from a primary squamous carcinoma of the tongue, from 2 subsequent local recurrences, and from 2 lymph-node metastases--all from the same patient. While the cell lines shared many morphological and biochemical characteristics, those derived from recurrences and metastases appeared to be less differentiated, were less well organized in culture, and displayed fewer desmosomes and tonofilaments than cells in the primary tumour line. A recurrent line showing greatest morphological divergence from the primary tumour line also demonstrated the greatest differences at the ultrastructural level, in increased production of plasminogen activator and in the composition of cell-surface glycoproteins.

Carcinoma, Squamous Cell↗

Curiosa paediatrica. III: Hemisternum.

Paediatricians know of the condition of pectus excavatum in the growing child and may be acquainted with other anomalies of the sternum, such as forked and perforate xiphisterna and perforations higher up the sternum. The sternal malformation depicted in this case report, although not unusual in appearance, has a most rare origin.

Child↗

Dr Alfred Cox and the South African Medical Association.

The stability and influence of the medical profession in South Africa rest in the South African Medical Association which owes its foundation to a man of inestimable worth and excellent character, but now unknown or long forgotten. This paper is intended as a tribute to Dr Alfred Cox, quondam Organizing Secretary of the British Medical Association, if it be only to place on record our omission to do honour where great honour is due.

History, 19th Century↗

A clinically applicable high-pressure liquid chromatographic method for measurement of serum theophylline, with detailed evaluation of interferences.

A high-pressure liquid chromatographic method for the routine measurement of serum theophylline that is accurate, specific, and sensitive is presented. It is technically simple, requires only 50 microliter serum, and takes relatively little technician time. Values for theophylline in sera obtained by this method correlate well with those obtained by use of a gas-liquid chromatographic method (r = 0.980) and with values obtained by the commonly used spectrophotometric method (r = 0.939) when the latter is free of interference. The assay has been employed for two years in a routine clinical chemistry laboratory, with interassay coefficients of variation of 2.4-3.2%. Interferences have been identified at an incidence rate of 3.8% of all specimens, and interfering substances include cephazolin, chloramphenicol, sulfamethoxazole, and sulfisoxazole. A calculation technic that allows a reliable and clinically useful estimation of a range of concentrations of theophylline in the serum when these interferences are present is described. In contrast, the incidence of interferences with the spectrophotometric method is 4.9%, and in this method the interferences prevent the analysis of theophylline. Of 33 samples having interferences by use of the spectrophotometric method, the high-pressure liquid chromatographic technic yielded precise values for theophylline in 21 and reliable estimates of ranges of concentrations of theophylline in the remaining 12.

Cefazolin↗

Curiosa paediatrica II.

A small series of a dermal curiosity occurring in children is described. It appears not to have been presented heretofore in medical writings and certainly not in our South African medical literature. The constancy of its presentation suggests strongly a genetic localization for its origin (if not a fanciful one!) and the name foveae scapularum cutaneae bilaterales congenitae in true dermatological fashion is wholly descriptive, ponderous though it be for such light 'residua pennarum'!

Child↗

Rudolf Virchow and Heinrich Schliemann. An essay on the friendship of two great men.

This essay briefly relates the great friendship between two great men whose origins and curricula vitae differed exceedingly, but whose common scientific interest in archaeology was to unite them closely. Virchow, a medical doctor, and Schliemann, a doctor of science, were able eventually to secure safekeeping for the Trojan treasure discovered by Schliemann, whose contributions to the culture of our Western civilization have not been surpassed. What has happened to the Trojan treasure since the occupation of Berlin is a question still unanswered.

Anthropology↗

Dr A. C. Jackson.

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Black or African American↗

Curiosa paediatrica.

Curious clinical conditions occasionally seen nowadays are most likely to be genetic aberrations. To find something which is curious but not abnormal nor, indeed, uncommon, but left unrecorded in our medical literature, is worth a notice. This is one of a small collection of curiosities, which I have called for academic reasons 'scalae abdominis infantis' (vel infantum) but the Editor has aptly dubbed the 'inbuilt football jersey'.

Abdomen↗