Occupational cancer and chemical structure: past, present, and future.
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Biomedical subjects
Publications and source records attributed to T J Haley.
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Twelve hundred and fifty-one pregnant women were contacted and their infants followed to age 5 years. Nine hundred and fifty-one (76%) children completed the trial. Measurements were made of birthweight, length, head circumference, and triceps skinfold at 10 days, and of weight, height, head circumference, and triceps at 5 years. Throughout the entire period of the study half the families, selected at random, were supplied with milk tokens entitling the mother, while pregnant, and all children under age 5 years, to 1 pint of milk a day at half its current price. The tokens led to a small increase in milk purchases by the families and to a small increase in milk drunk by the children. However no effect was detected in any growth measurement either in the total group, or in a more "vulnerable" group of children from the largest families.
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A more detailed analysis of material from the 20-year follow-up of men in the Rhondda Fach confirms the similarity between the Standardised Mortality Ratios (SMRs) of miners and exminers with radiological categories 0, 1, 2, 3 and A (120.3, 116.5, 119.0, 115.7, and 120.1 respectively) as well as the difference between these SMRs and that of the non-moners (98.7). The specific death rates show a raised SMR for bronchitis and other respiratory diseases excluding pneumoconiosis for all categories including category 0, but little difference between those for category 0 and those for simple pneumoconiosis. The SMRs for ischaemic heart disease and other circulatory diseases for categories A, B and C combined are lower than those for simple pneumoconiosis and category 0 (84.2 and 85.0, compared with 109.8 and 121.8 for simple pneumoconiosis, and 117.5 and 114.6 for category 0). Fortunately the SMR for leukaemia is low. A comparison between the survival rates of men aged 55-64 in Leigh, Lancashire and those in the Rhondda Fach suggests that nonminers in the two areas have similar survival rates while the survival rates for category 0 and simple pneumoconiosis are lower in the Rhondda Fach.
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A pharmacokinetic study of an intentional pentachlorophenol ingestion by an elderly human has been undertaken. Information on the presence or absence of forced diuresis either continuously or for a short restricted period indicates that such treatment would materially reduce the body burden of pentachlorophenol. It is suggested that forced diuresis is the treatment of preference for such intoxication at this time.
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