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Biomedical subjects

T J Eide

Publications and source records attributed to T J Eide.

At least 73 records · Page 4Linked to original sources
PubMed1985

Prevalence of polyps in an autopsy series from areas with varying incidence of large-bowel cancer.

The results of this multicentre autopsy study emphasize the relationship between the prevalence of adenomas and the incidence of large-bowel cancer. The highest proportion of autopsies with adenomas was observed in the area with the highest incidence of large-bowel cancer. The segmental distribution of adenomas within the colon was found to be similar to the site distribution of cancer. However, the lowest proportion of adenomas was found in the rectum, the segment in which cancer is most frequent. The latter finding suggests that either the adenoma-carcinoma sequence is a less important pathway in the pathogenesis of rectal cancer, or that more rectal than colonic adenomas become malignant. The high proportion of hyperplastic polyps in the rectum, and statistically significant regional differences following the same patterns as the incidence of rectal cancer suggest that there could be at least an indirect relationship between hyperplastic polyps and cancer of the rectum. Adenomas of both colon and rectum were more frequent in men than in women, contrary to findings with colon cancer. However, as for colon cancer, the sex ratio of adenomas changed with age, from slightly below unity in persons under 65, to above unity for those aged 65 and over. A major difficulty that emerged was the histological identification of "polyps" because of the degree of autolysis of epithelial cells in the mucous membrane, and this difficulty largely contributed to the poor consistency of histological reporting. Regular consistency surveys of histological preparations should be recommended in any type of multicentre study in which histological examination is included.

Adult↗
PubMed1985

Variant gamma-glutamyltransferase in colorectal carcinoma and liver metastasis. A case study.

Two variant forms of gamma-glutamyltransferase have recently been demonstrated in colorectal carcinoma. They differed from the enzyme in normal colon mucosa by altered sialic acid content, and Concanavalin A affinity. A search for a variant gamma-glutamyltransferase was undertaken in liver metastasis from one patient with colorectal carcinoma. The enzyme in the metastatic tissue was clearly different from the normal liver enzyme and apparently identical to the variant enzyme in the primary tumor. Thus, the variant form appears to be related to the neoplastic transformation. However, as antigenic properties of the metastatic enzyme were apparently identical to those of the normal liver enzyme, they will not be true isoenzymes.

Colon↗
PubMed1985

The probability of overlooking prostatic cancer in transurethrally resected material when different embedding practices are followed.

When all transurethrally resected material of 53 subsequent patients was microscopically examined, primary adenocarcinoma of the prostate was found in 18 patients and benign disease in 35. Only 9 of the patients with histologically confirmed malignancy of the prostate were clinically diagnosed. The proportion of prostatic chips that contained malignant tissue ranged from 1-96%. A mathematical analysis evaluating the probability of including a carcinoma when different numbers of blocks were processes was performed. The analysis showed that when the patient has a clinically malignant diagnosis the probability of 100% is reached by the processing of one block. If the patient has a clinically benign diagnosis, however, the probability of 98% is first reached by the processing of 8 blocks, if such an amount of material is available.

Adenocarcinoma↗
PubMed1985

The relationship between atherosclerosis of the thoracic aorta and renal scarring in an autopsy material.

With the aim of examining the possible association between atherosclerosis of the aorta and renal scarring, an autopsy study comprising 81 men and 43 women was performed. The per cent intimal surface involved with atherosclerosis in the aorta above the renal arteries was determined by morphometry, and the per cent surface profile of the kidney affected by scarring was measured microscopically in a standardized fashion. In addition, the following variables were determined: the age of the patient, diameter of the renal artery ostia, weight of the kidneys, heart weight, presence or absence of signs of sustained myocardial infarction, highest measured systolic blood pressure and the number of macroscopic renal scars. The data were subjected to both simple correlation and multiple regression analyses. In both men and women there was a significant simple correlation between the degree of atherosclerosis in the aorta and the extent of subcapsular microscopic renal scarring. In men, the prime importance of aortic atherosclerosis for microscopic renal scarring was supported in the multiple regression analysis. In women, this analysis showed that age was the determining predictive factor for microscopical renal scarring. The results may be taken to support the hypothesis that micro-embolism from an atherosclerotic aorta may be a cause of microscopic subcapsular scars in the kidneys.

Aged↗
PubMed1984

Clustering of adenomas in the large intestine.

In a necropsy study of 68 men and 36 women with single or multiple adenomas of the large intestine the distribution of all adenomas within the bowel in individual patients was examined. Each adenoma was recorded both by its distance in centimetres from the caecal pole and by the intestinal segment in which it was found. Adenomas in individual patients were shown to occur significantly closer together than expected from the general distribution of adenomas within each age group. The statistically significant, but not very strong effect of clustering may be caused by the existence of one or more fields of the large intestine specific to individuals who have a higher than average propensity for neoplastic development.

Adenoma↗
PubMed1984

Huge arteriovenous malformation in the mediastinum. Clinical presentation and surgical management.

A 24-year-old asymptomatic women presented with a large posterior mediastinal mass and a vertebral defect. Cardiac enlargement was found at roentgenographic and echocardiographic investigation. The ECG was abnormal and right heart catheterization showed cardiac output 17.1 l/min with a large left-to-right shunt at the level of the right atrium and the superior caval vein. The mass was seen on angiograms to be fed by numerous vessels originating from the descending aorta between the aortic arch and the coeliac axis. Computed tomography demonstrated a homogeneous, highly vascular structure. Radical excision was successfully accomplished in a two-step procedure aided by partial cardiopulmonary bypass. This seems to be the first report of a macrofistulous arteriovenous malformation in the mediastinum.

Adult↗
PubMed1984

Pancreatic cystadenoma. Angiographic and histologic findings illustrated by two cases.

Two cases of pancreatic cystadenoma are presented, demonstrating the typical angiographic and histologic pattern as given in previous literature. Although computed tomography and ultrasound examinations may be useful [11], angiography seems to play a decisive role in establishing the diagnosis, demonstrating the localization and extent of the tumor, and permitting the possible differentiation of benign and malignant lesions.

Aged↗
PubMed1984

Platelet trapping and haemodynamics in unilateral and bilateral experimental pulmonary macroembolism.

Cat lungs were embolized with autocoagulated autologous blood clots and the platelet-trapping ability of the lung vessels and the haemodynamic responses were studied. Embolization was bilateral or strictly unilateral. It elicited on average a twofold increase in 51Cr-labelled platelets in embolized parts of the lungs. Microscopy revealed platelet aggregates in arteries with diameter 50-100 microns. A temporary decrease in systemic platelets immediately postembolus was found. In the nonembolized lung at unilateral embolization the pulmonary platelet aggregation did not occur and no haemodynamic response was detected, indicating that platelet-aggregating substances or humoral factors did not recirculate from affected to unaffected parts of the lungs.

Animals↗
PubMed1983

Variant gamma-glutamyltransferases in colorectal carcinomas.

Two variants of gamma-glutamyltransferase were demonstrated in colorectal carcinomas. When compared to the enzyme in normal large bowel mucosa, one of the variants showed reduced affinity to concanavalin A and considerable charge heterogeneity largely due to variable sialic acid content. The other variant appeared to be an asialo form with no affinity to concanavalin A. The two novel forms were of identical size and antigenicity compared to the normal enzyme. They might therefore reflect different post-translational modifications of the carbohydrate moiety of the enzyme.

Aged↗
PubMed1983

Remnants of adenomas in colorectal carcinomas.

In consecutive large bowel resectates in patients older than age 20 years, primary colorectal cancer remnants of adenomas were histologically identified in 39 of 169 carcinomas (23%). Remnants of pure tubular adenomas were seen in 17 and of tubulovillous adenomas in 22 cases. There was no significant difference among sexes, intestinal segments, or age groups older than 55 years with the regard to the frequency of adenomas in carcinomas. A very low are (0.05) was found in patients of both sexes younger than 55 years. The frequency with which adenomas was identified was independent of tumor size. A high rate was found in those carcinomas which were limited to the submucosal layer (0.57), were well differentiated (0.43), and had an exophytic growth (0.54). Coexisting single or multiple adenomas at a distance from the main tumor were significantly more frequent in resectates in which adenomas was detected in the carcinoma (0.51) than in resectates in which no adenoma contiguous with the carcinoma was seen (0.30). The study shows that carcinomas develop from adenomas in all parts of the large intestine, but it cannot be concluded that all carcinomas in noncolitic patients develop from adenomas.

Adenoma↗
PubMed1981

Benign lipoblastomatosis: a cervical tumor of children.

Two cases are presented by a rarely reported cause of a supraclavicular mass in the neck of young children. Benign lipoblastomatosis has usually been confused clinically with cystic hygroma. The literature is reviewed and the histological differential diagnosis discussed.

Diagnosis, Differential↗
PubMed1981

Lipomatosis and true lipomas of the ileocecal valve.

Two patients with lipomatosis and two patients with true lipoma of the ileocecal valve are described. The symptomatology, radiological appearances, pathological findings and treatment are discussed. True lipomas of the ileocecal valve should be differentiated from the more commonly occurring lipomatosis or lipohyperplasia. The rare true lipomas have a demarcating capsule around the fatty tissue and are confined to only one of the ileocecal lips. The lipomatosis, on the other hand, is characterized by a diffus fatty deposition in the submucosa of the valve with no encapsulation. Lipomatosis as well as true lipomas may appear as rounded, smoothly outlined and sharply demarcated masses on barium enema examination. Occasionally, these filling defects may present problems of differential diagnosis with respect to malignant involvement of the ileocecal region. A correct preoperative diagnosis, however, is important to prevent unnecessary or too radical surgical treatment.

Aged↗
PubMed1981

Histologic and clinical findings in human scabies.

The epidermal histological findings in the primary scabetic lesion are hyperkeratosis, acanthosis, and spongiotic edema and vesiculation. The dermal changes consist of perivascular and diffuse cell infiltrates, mainly mononuclear cells, and sometimes eosinophilic granulocytes. The number of mast cells are slightly greater in primary scabetic lesions compared with secondary lesions and normal skin. Vasculitis is found in those cases showing tissue eosinophils, severe dermatitis, and many mites. A nodular lesion shows perivascular infiltrates mainly containing histiocytes, some with atypical and hyperchromatic nuclei and a few in mitosis, and some lymphocytes and cells with pyroninophilic cytoplasm. Secondary scabetic lesions show acanthosis and perivascular inflammatory cell infiltrates, mainly mononuclear cells, whereas clinically normal skin presents very slight perivascular and diffuse mononuclear cell infiltrates in half of the patients. Both the number of circulating eosinophilic granulocytes and serum IgE concentrations correlate with the severity of the skin reaction. Ten of 60 patients with scabies had markedly increased numbers of circulating eosinophilic granulocytes during scabies infestation. In most of the patients, however, the number of circulating eosinophils decreased after scabies treatment.

Biopsy↗
PubMed1980

Distribution of atherosclerosis in human descending thoracic aorta. A morphometric study.

A morphometric study of 49 randomly selected human aortas is reported with regard to the distribution of atherosclerotic lesions in the descending thoracic aorta (DTA). The intercostal artery area (ICA-area) revealed a higher degree of atherosclerosis compared with the remaining part of the DTA. The difference was more striking at overall lower grades of atherosclerosis of the DTA. The ventral aspect of the DTA in the proximal and caudal thirds showed a higher degree of atherosclerosis compared with the middle third. The atherosclerotic indices of the proximal and distal areas correlated significantly with increasing heart weights but not for the middle third. The explanation of this is, presumably, irregular flow conditions. For the distal part a possible effect of continuous pounding of an enlarged heart upon the ventral aspect of the descending thoracic aorta is discussed.

Aorta, Thoracic↗
PubMed1980

The diagnosis of carcinoma in transurethral resectates of of the prostate. A study of the probability of overlooking malignant tissue when only part of the material is embedded for histological examination.

The purpose of this retrospective study based on the findings in routinely processed material from fifty-two consecutive cases of prostatic carcinomas is a mathematical calculation of the probability of including a carcinoma in the histological sections from tissue obtained by transurethral resection of the prostate when different embedding practices are followed. The analysis shows that if a material of a composition similar to ours were examined, the calculated probability to include at least one prostatic chip with malgnant tissue in the histological sections would be about 91% if one paraffin-block is made. The probability increases to about 96% when two blocks are used and comes close to 99% with four blocks.

Aged↗