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Biomedical subjects

T Ishibe

Publications and source records attributed to T Ishibe.

At least 109 records · Page 6Linked to original sources
PubMed1977

Absorption and excretion of carbenicillin indanyl sodium in patients with reduced kidney function.

On eight volunteers with reduced kidney function, 1 g of carbenicillin indanyl sodium was administered orally for the single dose studies and was given orally in a dose of 1 g every 6 h for 7 days for the multiple dose studies. The patients were divided into two groups according to their kidney functions: group I moderately impaired and group II severely impaired. In the single dose studies, the mean peak level was 12.6 microgram/ml for group I and 26.9 microgram/ml for group II. In the multiple dose studies, the drug tended to accumulate in group II, but the level obtained in group II did not exceed more than 300 microgram/ml. In the single dose studies, the mean peak level in the urine was 1,478.5 microgram/ml for group I and 350.0 microgram/ml for group II. In the multiple dose studies, despite the multiple dose regimen, the level obtained from group II patients only transiently exceeded more than that which will effectively inhibit the growth of Pseudomonas, Klebsiella and Enterobacter. In the single dose studies, the mean cumulative amount excreted in the urine within 24 h was 314.2 mg for group I and 120.1 mg for group II and the difference between both groups was significant (p less than 0.05). For the multiple dose studies, the amount was 278.0 mg for group I and 127.2 mg for group II, respectively. The total amount excreted in the urine within 24 h and the serum level obtained 6 h after ingestion of 1 g of carbenicillin indanyl sodium was correlated to the creatinine clearance and the rate of PSP excreted in the urine within the first 15 min of the test.

Administration, Oral↗
PubMed1977

Alterations of serum lactic dehydrogenase and its isoenzyme V fraction levels following hyperglycemic condition in patients with geitourinary neoplasms.

In patients with various genitourinary neoplasms, except in those with untreated bladder carcinoma, changes of SLDH and SLDH-V fraction levels owing to hyperglycemic conditions were statistically not significant to the pretreatment levels. In patients with untreated bladder carcinoma, the levels after 48 h were statistically significantly lower than the pretreatment levels. However, these decreases disappeared after radical treatment. In patients having abnormally high pretreatment levels, the frequency of cases which decreased to more than 20% of their pretreatment levels was 47% for SLDH and 60% for SLDH-V. This test was useful not only as a diagnostic tool, but also as a means of predicting therapeutic results.

Adenocarcinoma↗
PubMed1976

Liver function in porstatic carcinoma patients.

Liver function tests were carried out for serum zinc turbidity test, icterus index, alkaline phosphatase, bilirubin and transaminases in a series of 222 patients, of whom 119 had prostatic carcinoma, 63 benign hyperplasia of the prostate and 40 congenital abnormality without prostatic trouble. Patients having prostatic carcinoma often displayed abnormally high levels of zinc turbidity test, alkaline phosphatase, bilirubin and transaminases.

Aged↗
PubMed1976

Prognostic usefulness of serum lactic dehydrogenase and its fifth isoenzyme levels in carcinoma of the prostate.

Antiandrogenic treatment with castration, intravenous diethylstibestrol diphosphate and oral estradiol benzoate was given to 51 patients with prostatic carcinoma. The interrelationship between the clinical response to this treatment and the changes of serum lactic dehydrogenase (SLDH) and SLDH isoenzyme V fraction (SLDH-V) level was studied. Pretreatment SLDH level is significant in regard to the 5-year survival rate. Response of SLDH and SLDH-V levels to antiandrogenic treatment has no significant influence on the 5-year survival rates. As regard the index of the 5-year survival rate in patients with prostatic carcinoma, SLDH-V was almost as specific as SLDH.

Clinical Enzyme Tests↗
PubMed1976

Prognostic value of liver function tests in carcinoma of the prostate.

The interrelationship of the liver function tests and the 5-year survival rates were studied in 62 patients with prostatic carcinoma who were treated with antiandrogens. Abnormally high bilirubin, and glutamic oxaloacetic and pyruvic transaminase serum levels were a significant index with regard to the 5-year survival rates.

Alkaline Phosphatase↗
PubMed1975

Retrocaval ureter with carcinoma of the renal pelvis: report of a case.

A case of retrocaval ureter associated with carcinoma of the renal pelvis has been presented. This is the 2nd such case out of 110 cases reported in Japan. It is suggested that long term stagnation of urine is the cause for such a high incidence of malignant neoplasm involving the renal pelvis.

Adult↗
PubMed1975

Effect of long-term estrogen treatment on liver function in patients with prostatic carcinoma.

To evaluate the effect on liver function of therapy with massive doses of synthetic female sex hormones a study was performed on the alterations in levels of serum zinc turbidity test, bilirubin, alkaline phosphatase, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase following antiandrogenic treatment with castration and synthetic female sex hormones in patients with prostatic carcinoma. Results included: 1) Irrespective or response to treatment the zinc turbidity test level tended to increase. 2) After 1 week of treatment some increase was observed in the alkaline phosphatase level and was more pronounced in poor response cases than in the fair ones. However, in general, no definite fluctuation was observed. 3) The bilirubin level tended to decrease in general but in poor response cases an early increase was observed. 4) The glutamic oxaloacetic transaminase level was significantly increased in the early phase and more pronounced in poor response cases than in the fair ones. 5) An increased glutamic pyruvic transaminase level was observed after 2 weeks of treatment but was not significant to the pre-treatment level and later returned to the neighborhood of the pre-treatment level. After 1 week of female sex hormone therapy many indices studied showed abnormality. However, except for a steady increase in the zinc turbidity test level no serious damage on liver functions evaluated was encountered during a year of massive dose therapy with female sex hormones.

Aged↗