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Biomedical subjects

T Imamura

Publications and source records attributed to T Imamura.

At least 649 records · Page 36Linked to original sources
PubMed1982

Malignant fibrous histiocytoma of the nasal septum. A report of an unusual lesion.

A case of malignant fibrous histiocytoma of the nasal septum is described in a 51-year-old woman who has presented with nasal pain, nasal obstruction and a swelling at the base of the nose. Histological examination revealed a malignant fibrous histiocytoma. Total resection of the tumor was performed and, 26 months after operation, the patient was well and free of recurrence or metastasis. This is the first reported case of malignant fibrous histiocytoma of the nasal septum.

Female↗
PubMed1982

Hypoglycemia, hypopotassemia and hyperleukocytosis associated with squamous cell carcinoma of the lung.

We studied a patient with lung cancer, who exhibited severe systemic derangements of metabolism causing cachexia preceding the appearance of a large bulky tumor. The data described herein left no doubt that lung cancer growing in the patient acted as a powerful hypoglycemic factor, setting in motion widespread metabolic disorders. Inappropriate secretion of insulin may be involved in the manifestation of hypoglycemia. However, no ectopic secretion of insulin, glucagon, ACTH and aldosterone appeared to be associated with the carcinoma in the patient. From the present and previous observations, it is stressed that progressive energy loss from the patient occurs by virtue of a combination of severe anorexia and the establishment of a systemic energy-losing cycle dependent on an interplay of glycolysis in the cancer cells and stimulated gluconeogenesis in the host tissues, which in turn results in derangements of protein, lipid and electrolyte metabolism. Attempts to ameliorate the patient's distress and counterbalance the effect of the tumor by parenteral hyperalimentation were not satisfactory and resulted in only a temporary improvement. This study also demonstrated that marked granulocytosis was the result of production of an excess granulopoietic colony stimulating activity by the cancer cells.

Cachexia↗
PubMed1982

Subacute sclerosing panencephalitis. An autopsy case with impaired cellular immunity.

An autopsy case of subacute sclerosing panencephalitis (SSPE) in a 5-year-old boy, with rapid progression to a comatose state in 2 weeks after the onset of right hemiplegia, is described. The levels of antibody to measles virus in the serum and the cerebrospinal fluid were increased, and high levels of IgG in the latter were found. A characteristic pattern of electroencephalogram (EEG) showing periodic suppression of high voltage complexes was also found during the course of the disease. Microscopical examination revealed perivascular cuffing, numerous hypertrophied astrocytes with a diffuse gliosis and sporadic intranuclear inclusions in the brain. In addition to these typical findings of SSPE, impaired cellular immunity was recognized by delayed skin test in vivo, and pathologically severe atrophy of thymus, and follicular atrophy of spleen with amyloid deposition in the wall of the sheathed arteries were found.

Antibodies, Viral↗
PubMed1981

Separation of low molecular weight RNA species by high-speed gel filtration.

By employing a high-speed gel filtration method using a column of silica-based aqueous gel, TSK-GEL G 300 SW, the three low molecular weight RNA species, 5.8S and 5S rRNA, and tRNA, were clearly separated from each other and from high molecular weight RNA species in 200 mM sodium phosphate buffer, pH 7.0, containing 0.1% SDS. Excellent reproducibility and resolution were obtained under these conditions, about 30 min being required for a single run. Furthermore, the 5.8S rRNA from rat liver cells was eluted at a different position compared with that of the yeast, Saccharomyces cerevisiae, although they have the same nucleotide chain length but at different sequence. The 5.8S rRNA from the cellular slime mold, Dictyostelium discoideum, was eluted at the same position as that of yeast.

Animals↗
PubMed1981

Transformation of bile acids by mixed microbial cultures from human feces and bile acid transforming activities of isolated bacterial strains.

Microbiol transformation of cholic acid and chenodeoxycholic acid by anaerobic mixed cultures of human fecal microorganisms was investigated, and the results were examined in relation to the bile acid transforming activities of 75 bacterial strains isolated from the same fecal cultures. The reactions involved in the mixed cultures were dehydrogenation and dehydroxylation of the 7 alpha-hydroxy group in both primary bile acids and epimerization of the 3 alpha-hydroxy group in all metabolic bile acids. Extensive epimerization of the 7 alpha-hydroxy group of chenodeoxycholic acid yielding ursodeoxycholic acid was also demonstrated by certain fecal samples. 7 alpha-Dehydrogenase activity was widespread among the fecal isolates (88% of 16 facultative anaerobes and 51% of 59 obligate anaerobes), and 7 alpha-dehydroxylase activity was revealed in one of the isolates, and unidentified gram-positive nonsporeforming anaerobic bacterium. 3 alpha-Epimerization was effected by seven strains assigned to Eubacterium lentum, which were also active for 3 alpha- and 7 alpha-dehydrogenations. No microorganism accounting for 7 alpha-epimerization was recovered among the isolates. Splitting of conjugated bile acid was demonstrated by the majority of obligate anaerobes but the activity was rare among facultative anaerobes.

Bacteria↗
PubMed1981

The TC double socket above-knee prosthesis.

The conventional total contact suction AK prosthesis presents several disadvantages, such as difficulty in wearing the socket in a sitting position, difficulty in obtaining a favourable disposition of the stump soft tissues in the socket and difficulty in avoiding stump perspiration problems. In an attempt to solve these disadvantages, a new AK prosthesis with a thermoplastic double socket was developed at the Tokyo Metropolitan Rehabilitation Center for the Physically and Mentally Handicapped. The double socket is composed of an external socket attached to the lower parts and a detachable internal socket, and appears to solve all the disadvantages of the conventional prosthesis. This prosthesis is called the TC prosthesis, and abbreviation for the Tokyo Metropolitan Rehabilitation Center. The first model of this prosthesis, (TC-1) has a metal valve. A new rubber sheet valve was developed to solve several disadvantages of the metal valve in the TC-2 prosthesis. Since November 1978 the TC-1 has been fitted to 295 AK amputees, including 9 bilateral AK amputees, and since March 1980, 145 AK amputees have received the TC-2, including 6 bilateral amputees. Satisfactory results have been obtained with both prostheses.

Amputation Stumps↗