Biomedical subjects
T Harris
Publications and source records attributed to T Harris.
Social origins of depression: a reply.
Many of the criticisms of our work made by Tennant & Bebbington in the current edition of this journal touch on issues which have already been discussed in our recent book Social Origins of Depression. We do not think that any of their points pose significant threats to our aetiological model of depression. We welcome this opportunity to clarify their questions about our data, and to use their re-analysis of our material as a basis for a wider discussion of certain general aspects of the statistical analysis and interpretation of data and the pitfalls which await the unwary.
Psychiatric disorder in London and North Uist.
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Further studies on interviewer training and inter-rater reliability of the Present State Examination (PSE).
The Present State Examination (PSE) is discussed with regard to its use in surveys of subjects who are not psychiatric patients. Although the PSE was originally developed for use by psychiatrists with patients with obvious mental illness, the interview also contains sections dealing in considerable detail with the commoner and less severe complaints and symptoms that are found in a significant proportion of 'normal subjects'. A shortened version of the PSE (8th edition) is described, limited to these sections, which has been used in population surveys, by interviewers who are not psychiatrists, The training of such interviewers is described, and information on a reliability and repeatability study is presented. This shows that with proper training, non-psychiatric interviewers can achieve standards of inter-rater reliability that are comparable to those previously reported between psychiatrists.
Depression and loss.
Recent losses occurring in the two years before onset of depression in women are distinguished from past losses occurring at any time before this. Of past losses only loss of mother before II is associated with greater risk of depression--both among women treated by psychiatrists and among women found to be suffering from depression in a random sample of 458 women living in London. Past loss of a father or sibling before 17 (or a mother between II and 17), or a child or husband, is not associated with a greater chance of developing depression. However, among patients all types of past loss by death are associated with psychotic-like depressive symptoms (and their severity) and other types of past loss with neurotic-type depressive symptoms (and their severity). It is argued that these associations probably reflect direct causal links, and a sociopsychological theory to explain them is discussed.
Care of the critically ill newborn: continuous positive airway pressure.
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An unusual case of poisoning in babies.
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[Biosynthesis, distribution and excretion of 3-acetyl-6-pryidone, a metabolite of 3-acetylpyridine].
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Medical problems related to the hostile environment. I. Problems related to closed ecologic systems.
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A Contribution to the Pathological Anatomy of Pneumonokoniosis (Chalicosis pulmonum).
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Case of Chronic Lobar Pneumonia.
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Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival.
Effective cellular immune responses require increases in antigen-specific T lymphocytes; IL-2 drives antigen-stimulated T cell proliferation and is largely responsible for the increases observed. We used microarrays containing approximately 9000 mouse cDNAs to study IL-2-induced gene expression. IL-2 induces the expression of genes that regulate cell cycle progression, control cell survival, and increase synthetic and metabolic processes during proliferation. IL-2 also suppresses expression of genes that block cell cycle progression and promote cell death. Rapamycin inhibits IL-2-driven proliferation by downregulating the expression of genes required for key processes required for cell cycle progression. Rapamycin also preserves cell survival by keeping intact the IL-2-induced cell survival programs. These complex multifaceted programs of gene expression permit a dynamic regulation of cellular proliferation and cellular survival.
Life stress, chronic subclinical symptoms and vulnerability to clinical depression.
Prospective enquiries of the role of social factors in the aetiology of depression are faced with the problem of who to exclude from the enquiry in terms of psychiatric symptomatology present at first contact. With this problem in mind the role of subclinical symptoms among women not cases of depression has been examined in terms of their relation with a subsequent onset of caseness depression. Psychosocial factors of particular importance in the development of such depression were low self-esteem, marked long-term difficulties and severe life events arising out of (or 'matching') these difficulties. These psychosocial factors were also correlated with the presence of subclinical symptoms. It is concluded that although subclinical symptoms relate to a raised risk of subsequent depression at a caseness level there is no evidence that there is inherent vulnerability stemming from such subclinical symptoms over and above that explained by the psychosocial correlates.
Is weight loss a modifier of the cholesterol-heart disease relationship in older persons? Data from the NHANES I Epidemiologic Follow-up Study.
The relationship between cholesterol and 14-year incidence of coronary heart disease was compared for men and women of two age groups, 25 to 64 years and 65 to 74 years. While cholesterol levels of 6.2 mmol/L or higher were associated with a risk of coronary heart disease in the younger group, this was not true for either men or women aged 65 to 74. Further analyses for older persons showed that weight loss modified the cholesterol-heart disease relationship. Those with stable weight showed a positive relationship between cholesterol and coronary heart disease, similar to the younger age group (relative risk [RR] = 1.8 [95% confidence interval: 1.1, 2.9] for men; RR = 1.6 [.7, 3.4] for women). Among those with a weight loss of 10% or more, the relationship of cholesterol to heart disease was inverse (RR = .8 [.5, 1.2] for men; RR = .6 [.3, 1.0] for women). These data suggest that the relationship of cholesterol to coronary disease in healthier older persons may be similar to that in younger persons, and that health status should be considered in analyses of cholesterol risk in old age.
Scrapie. Persistently puzzling prions.
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A Wj-negative patient with anti-Wj.
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Women and alzheimer disease.
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Examination of several instruments for the electrical detection of holes in latex gloves during use.
The initial purpose of this research was to investigate the use of electrical conductivity for detecting holes in latex gloves, while they are being worn, using both recently developed devices and laboratory equipment. The individual devices were not evaluated or critically compared. The use of this technique as a quality assurance procedure, and to determine the degradation of latex gloves due to storage and exposure to disinfectants, was also investigated. The following conclusions were reached: (1) These devices alarm if the latex is breached by an object of at least 300 um-diameter and both the inside and outside of the glove are wet with a conductive fluid. False alarms from latex hydration is the primary disadvantage. (2) This technique is a sensitive QA procedure if any hole to be detected is wet with a conductive liquid. (3) Sealed, sterile latex gloves may degrade over many months. (4) There was no obvious degradation of latex gloves after two hours' exposure to three commonly used disinfectants.