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Biomedical subjects

T Harada

Publications and source records attributed to T Harada.

At least 1,063 records · Page 59Linked to original sources
PubMed1983

[Divergent histology in the primary and metastatic lesions of thyroid carcinoma].

The metastatic lesions of malignant diseases tend to present similar histological findings as the primary tumor. However, thyroid carcinoma is one of the malignancies which may be an exception to this rule. We have reviewed 61 consecutive autopsies of thyroid cancer patients at the Ito Hospital and Kawasaki Medical School Hospital during a period between 1969-1982. Fifty-five of 61 cases of thyroid carcinoma were found to have metastatic spreads beyond the thyroid. The uniform pathological findings were present in 5 of 9 papillary adenocarcinomas, 14 of 15 anaplastic carcinomas, and 1 of two squamous cell carcinoma and one epidermoid carcinoma. The remaining 36 patients were found to have different histological findings in metastatic lesions from the primary tumor. The histological types in coexisting metastases varied from one lesion to the other; the primary tumor was adenocarcinoma, but one of the metastases was anaplastic and the others showed adenocarcinoma or its combination. Those histological divergence in the primary tumor and metastases can be considered as the results of anaplastic or squamous cell transformation from adenocarcinoma. Such alteration of the histological findings in thyroid carcinoma calls for the reassessment of the therapeutic strategy.

Adenocarcinoma↗
PubMed1983

[Four cases of so-called atypical central serous choroidopathy].

Four cases of atypical central serous choroidopathy are presented. Serous detachment of the neuro-epithelium associated with multiple yellowish exudates in the macular region was an initial change, and this was followed by peripheral detachment. This condition is considered to be an allied disorder to central serous choroidopathy, fluorescein angiography showing leakage points or detachment of the retinal pigment epithelium, and photocoagulation with Xenon or laser to these points leading to recovery in three of the four cases, though it appears to be closely related to posterior uveitis.

Adult↗
PubMed1982

Carcinoembryonic antigen producing cultured cell lines enable detection of autoantibodies in sera from patients with gastrointestinal cancer.

Of 16 human malignant tumor cell lines established in our laboratory, seven lines, including three gastric cancer cell lines derived from patients with cancer, were found to carry carcinoembryonic antigen on their cell surface, as determined by radioimmunoassay and indirect immunofluorescence. The existence of antibodies (IgG class) against the gastric cancer cell lines (HPE-GAC-T, -2, -3) and lung cancer cell line (HPL-Ad-K) in the sera of patients with gastrointestinal cancer (incidence 70.8%) was demonstrated by indirect immunofluorescence. In nonmalignant cases and healthy controls, the incidence was 7.7 and 3.2%, respectively. Specificity of the antibodies detected in the sera of patients with gastric cancer was examined by absorption and blocking test methods of immunofluorescence. Even though there was an apparent heterogeneity of the specificity among the antibodies, the detection of such antibodies may be a feasible and practical approach to a clinical diagnosis of malignancy.

Adult↗
PubMed1982

Squamous cell carcinoma of the thyroid gland -- transition from adenocarcinoma.

Eight autopsy cases of thyroid carcinoma, in which adenocarcinoma and squamous cell carcinoma coexisted, and presented. In these adenosquamous cell carcinoma, pathological findings suggest direct transition from papillary adenocarcinoma to squamous cell carcinoma, rather than transformation to squamous cell carcinoma via squamous metaplasia. We believe that squamous cell carcinoma arises from adenocarcinoma of the thyroid in most cases.

Adenocarcinoma, Papillary↗
PubMed1982

Efficacy and side effects of the regional arterial infusion of anti-cancer drugs combined with direct hemoperfusion in malignancies of the urinary tract.

Regional arterial infusion of high doses of anti-cancer drugs combined with direct hemoperfusion was done in 12 patients with malignancies of the urinary tract. The perfuser contained 130 gm. activated charcoal, which was coated with cellulose. General toxicity caused by escape of the drug from the tumor area was prevented by adsorption within activated charcoal. The capacity of activated charcoal to adsorb doxorubicin hydrochloride was excellent, as determined by measurements of plasma concentration. With this method, objective tumor reduction was noted in 84 per cent of the patients with prostatic or bladder carcinoma, although results were disappointing in patients with renal cell carcinoma.

Adenocarcinoma↗
PubMed1982

High incidence of angiosarcomas in brown-fat tissue and livers of mice fed sterigmatocystin.

BDF1 female mice fed 30 or 120 ppm sterigmatocystin in their diet for 55 or 51 wk, respectively, developed angiosarcomas of the liver and of the dorsal brown-fat tissue. No tumours were observed in five mice from each group, including the controls, killed after 43 wk, but angiosarcomas were observed in mice from the test groups that died or were killed after more than 43 wk of treatment with sterigmatocystin. Thirty-four out of 53 mice (64.2%) fed 30 ppm sterigmatocystin developed hepatic angiosarcomas. Six (11.3%) of those fed 30 ppm sterigmatocystin and 27 out of the 51 mice (52.9%) fed 120 ppm developed angiosarcomas in the dorsal brown-fat tissue. Benign vascular lesions in the liver and a few angiosarcomas of the ovary and lung were also observed in mice of both test groups. No vascular changes were observed in control mice except for peliosis-like lesions in the spleens of two mice. Increases in the incidences of lung and hepatocellular adenomas were also observed in sterigmatocystin-treated mice.

Adipose Tissue, Brown↗