The pathogenesis of corneal inflammation due to Herpes simplex virus. I. Corneal hypersensitivity in the rabbit.
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Biomedical subjects
Publications and source records attributed to T H Pettit.
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Two siblings, a boy and a girl, developed a chronic, bilateral conjunctivitis with large recurrent pseudomembranes. The diagnosis of ligneous conjunctivitis was made by excisional biopsies in both. The family was referred for genetic counseling after the second child developed the disorder. On the basis of this family and previous reports, we believe that ligneous conjunctivitis is a genetic disorder inherited in an autosomal recessive pattern and that genetic counseling should be offered to the parents of affected children.
Freehand corneoscleral lamellar grafts were used in the treatment of advanced Terrien's marginal degeneration of the cornea in four eyes of three patients followed over a period of 12 to 20 years. Anatomic reconstruction of the ectatic thinned peripheral cornea was achieved and irregular astigmatism eliminated in all four eyes. Corneal astigmatism secondary to the corneal ectasia was reduced by 4.00 to 9.00 diopters. The progressive increase in against-the-rule astigmatism associated with advancing Terrien's was arrested for up to 20 years. Gradual thinning of the lamellar graft was noted in all four eyes after 10 years, but the return of corneal ectasia and increasing astigmatism has not occurred.