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Biomedical subjects

T Gelfand

Publications and source records attributed to T Gelfand.

At least 19 recordsLinked to original sources

Neurologist or psychiatrist? The public and private domains of Jean-Martin Charcot.

The emergence of neurology as an autonomous, prestigious field in late-nineteenth-century Paris is well known. Less appreciated is the role that neurologists played vis-à-vis the cognate older field of psychiatry. Taking Jean-Martin Charcot, the most influential neurologist of his time, as a test case, this paper contrasts his attitudes and practice in the public setting of teaching and hospital work with his private practice. A staunch defender of a clear distinction between his field and psychiatry, Charcot's private practice displayed more flexibility. Treating hysteria and neurasthenia created a middle ground of nervous diseases for him to cultivate. Unpublished case histories and other materials, especially from the Charcot library, support the conception of neurologists as active agents in constituting a new psychological medicine.

Famous Persons↗

Hysteria behind the scenes: Jane Avril at the Salpetriere.

Jane Avril (1868-1943), the famous dancer of the Moulin Rouge, immortalized by Toulouse-Lautrec, left behind published Memoires (1933). Trustworthy and written with verve, they include an account of her admission to Charcot's service at the Salpetriere in December 1882. There she was kept until June 1884, not so much because of illness but to protect her from her mother's abuse. Jane Avril provides unvarnished testimony of the daily life of the women with hysteria among whom she lived. She wrongly accuses them of simulation. But she accurately portrays the rivalry of the 'crazy girls' who vied to become the center of attention, and she sheds light on the factors that came together to make hysteria contagious (she herself escaped), the loading of symptomatology and the cultivation of the ailment. Charcot has been criticized on this score, since he showed his recognition of the underlying process when he pronounced isolation to be necessary to treatment. If Charcot accommodated hysteria, the ailment amply rewarded him with a fame that continues to this day to overshadow his achievement in neuropathology that he brilliantly forged using the "anatomo-clinical method."

Dancing↗

Novelization.

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Biographies as Topic↗

[How Charcot got his chair].

Charcot's career, as is well-known, reached a summit with his acquisition of the Faculty clinical chair of diseases of the nervous system inaugurated in 1882. Based upon previously untapped archival materials at the Charcot Library and the National Archives, this paper explores four questions: I. Was "Charcot's chair" really the first specialized chair for neurology?; 2. Was it founded specifically for Charcot?; 3. What role did the Faculty of Medicine play and did it offer any opposition?; 4. How important was the creation of the chair for the flourishing of the Salpêtrière school. Evidence is presented to show that Charcot considered a specialized chair in nervous diseases a high priority for his career and his school. Sometime around 1880, convinced of the importance of this project, he began to assemble arguments in its behalf from French and foreign sources, particularly from his German colleagues, Westphal and Erb. He learned that there were no precedents, not even in Berlin. Charcot's carefully prepared manuscript memoir presented a strong case for the "necessity" of the chair based on the recent progress and theoretical as well as practical importance of his subject. He described psychiatry, which already had a Faculty clinical chair, as but a "small part" of neuropathology and rejected the idea of combining the two disciplines. Although the project encountered opposition from several Faculty colleagues, who claimed that it was a personal favor for Charcot, powerful support from political allies such as Gambetta and Ferry ensured government funding. In fact, government action in behalf of the creation of the chair for Charcot preceded and surprised the medical Faculty. This paper shows the extent to which Charcot's own initiatives and arguments set the agenda and defined the role he envisaged for the new foundation at the center of the clinical research and teaching centre emerging under his direction at the Salpêtrière.

Clinical Medicine↗

[Not Available].

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France↗

[Not Available].

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France↗

[Not Available].

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Equipment and Supplies↗

Patterns of fibronectin deposition in normal and neoplastic fibroblasts and mammary tissue.

Deposition of fibronectin (FN) was studied by indirect immunofluorescent staining, employing monospecific rabbit anti-human FN antibody, in the following 3 systems: cultures of cells derived from Rous sarcomas of chickens and of normal chick fibroblasts; frozen sections of chicken Rous sarcomas; and frozen sections of mouse and human mammary tissue, normal and neoplastic. The normal fibroblasts produced a well-oriented, delicate, fibrillar FN network. The sarcoma cells in culture also formed a FN-positive matrix, but one very different in appearance, consisting of coarse, unoriented strands. FN was also present abundantly between the cells of the sarcomas in vivo. In normal mammary tissue, FN was localized predominantly in the basal lamina region, well delineated from the surrounding FN-reactive stroma. The epithelial cells were generally, but not always, FN-negative. In apparently normal tissue areas of the breasts of mammary carcinoma patients, epithelial cells with highly reactive cell peripheries were frequently seen; the stroma surrounding the positive cells was often poor in FN and the basal lamina region lacked the substance. Mammary carcinoma cells were almost always negative, but it was characteristic of these tumours that the surrounding stroma displayed FN richly.

Animals↗