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Biomedical subjects

T Fukuda

Publications and source records attributed to T Fukuda.

At least 1,171 records · Page 65Linked to original sources
PubMed1981

Neorickettsia-like organism isolated from metacercaria of a fluke, Stellantchasmus falcatus.

"Hyuga" fever, reportedly caused by Rickettsia sennetsu, occurring in the west of Japan was suspected to be an endoparasite-borne rickettsiosis. No R. sennetsu, however, was detected in metacercariae found in the muscles of grey mullets (Mugil cephalus) ingested raw by most "Hyuga" fever patients. Instead, another neorickettsia-like organism (SF strain) was isolated occasionally from metacercariae of Stellantchasmus falcatus. A dog was inoculated with SF strain. It developed mild fever after an incubation period of 10 days. No other clinical sign nor any macroscopic change upon autopsy was noted. The organisms were detected in its blood, lymph nodes and spleen, but not further transmissible. From these findings, the pathogenicity of SF strain to the dog seemed to be much lower than that of Neorickettsia helminthoeca or the Elokomin fluke fever agent of neorickettsia. These experiments support our presumption that SF strain may be a new member of neorickettsia, although no comparison of the antigenicity between SF strain and other neorickettsiae has been made.

Animals↗
PubMed1981

[Cranial computed tomography of the neurofibromatosis (author's transl)].

The computed tomography (CT) was performed in 10 cases of neurofibromatosis. The CT scan showed the abnormal findings in 8 cases out of 10. Skull lesions were noted in 3 cases and intracranial tumors were found in 5 among which multiple neoplasms were seen in 3. Although reported cases were not large enough in number, the incidence and variety of the tumors were similar to others reported before CT era.

Adolescent↗
PubMed1981

[Behavioral and EEG effects of coixol (6-methoxybenzoxazolone), one of the components in Coix Lachryma-Jobi L. var. ma-yuen Stapf].

Coixol (6-methoxybenzoxazolone) contained in Coix Lachryma-Jobi L. var. ma-yuen Stapf was compared with chlorzoxazone with respect to behavioral and EEG effects in mice and rats. Coixol 50-100 mg/kg, i.p. decreased locomotor activities of both species and produced hypothermia in rats. These effects of coixol were the same in potency as chlorzoxazone given in the same dose. Coixol was approximately twice as potent as chlorzoxazone in potentiating thiopental-induced sleep. This compound attenuated the writhing syndrome induced by 1% acetic acid and increased the threshold to jumping response induced by foot shock, to the same degree as seen with chlorzoxazone. Coixol was equipotent to chlorzoxazone in preventing convulsions induced by maximal electro-shock, while it was about 1.5 times more potent than chlorzoxazone in suppressing pentylenetetrazol-induced convulsion. Coixol 20-100 mg/kg inhibited the lever pressing response of hypothalamic self-stimulation in rats. In rats with chronically implanted electrodes, coixol 50-100 mg/kg induced drowsy patterns on the spontaneous EEG. The EEG arousal response to the external auditory stimulation was inhibited by the same doses of coixol, whereas it failed to suppress the arousal response to the midbrain reticular stimulation. These results indicate that coixol has pharmacological properties qualitatively similar to chlorzoxazone and acts as a central muscle relaxant with an anti-convulsant effect.

Analgesics↗
PubMed1981

[Antiulcerogenic action of 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509), a new benzodiazepine derivative].

Effects of KB-509, a new derivative of benzodiazepines and expected to be classified as an antianxiety drug, were studied on the experimental stress ulcers and serum 11-hydroxycorticosterone (11-OHCS) in mice. Firstly, we looked for a stress procedure under which diazepam would show antiulcerogenic effects at a lower dose than those required for a muscle relaxant effect in this species. We found that diazepam possessed a strong antiulcerogenic activity under the stress procedure (26 degrees C, 5 hr restraint and water immersion). KB-509 had a potent protective effect on the erosions induced by the present mild stress method at a considerably low dose (ED50: 0.36 mg/kg, p.o.) and the potency was about 3 and 9 times greater than that of diazepam and atropine sulfate, respectively. KB-509 did not affect indomethacin-induced gastric erosions and thermal ulcers, as did diazepam. KB-509 and diazepam depressed stress-induced increase of serum 11-OHCS in mice, but not at the low doses required for antiulcerogenic effects. In conclusion, the results in this study suggest that the stress method described may be used to evaluate the antianxiety effect of benzodiazepines, especially in mice, and that KB-509 is superior to both diazepam and atropine in antiulcerogenic activity.

11-Hydroxycorticosteroids↗
PubMed1981

[Electromyographic study of the gastric motility after atypical selective proximal vagotomy (author's transl)].

During selective proximal vagotomy (SPV), atypical SPV (atyp-SPV) was proposed when either the anterior or posterior nerve of Latarjet was sacrificed. In order to study the gastric motility after atyp-SPV, eight mongrel dogs on which SPV had been performed underwent atyp-SPV, with subsequent transthoracic truncal vagotomy (TV). These surgeries were performed at about 4 to 5 week intervals, and gastric myoelectrical activities were recorded serially through chronically implanted four bipolar electrodes in the stomach. In another four dogs with atyp-SPV, contractile activities of the gastric wall were recorded by means of waterproof strain gauges sutured on the gastric wall. Following atyp-SPV, the mean propagation velocity and discharge interval of the stomach were approximately similar to those in SPV, except for slightly decreased propagation velocity and slightly prolonged discharge intervals in only the early postprandial period after transection of the posterior nerve of Latarjet. Subsequent TV decreased the propagation velocity significantly although it did not alter the discharge intervals except in the early postprandial period. Atyp-SPV maintained gastric contraction with a waxing and waning pattern of varying amplitudes in the antrum and monotonic activities in the corpus. These results substantiate that atyp-SPV keeps gastric motility similar to SPV and can be performed as an alternate modality of SPV, when necessary.

Animals↗