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Biomedical subjects

T Fukaya

Publications and source records attributed to T Fukaya.

At least 163 records · Page 9Linked to original sources
PubMed1983

Cord serum growth hormone in the human fetus. Sex difference and a negative correlation with birth weight.

Cord venous growth hormone (GH) were measured by radioimmunoassay in 88 infants and 11 anencephalic infants. The mean GH levels decreased gradually from midgestation, preterm to term fetus. There was a significant (p less than 0.01) sex difference in the GH level of term fetuses. Anencephalic infants had low GH levels. There was a significant (p less than 0.01) negative correlation between the cord GH level and birth weight in the normal infant. These data suggest that there is a sex difference for fetal GH secretion and that GH is not so important for fetal growth, but the hypothalamus plays an essential role in the regulation of fetal GH secretion.

Anencephaly↗
PubMed1983

Human ACTH, beta-lipotropin and beta-endorphin levels in maternal plasma at delivery.

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-EP) were measured simultaneously in maternal plasma at delivery. Mean concentrations of beta-LPH and beta-EP in maternal plasma at delivery were significantly higher than those in normal control. There were significant positive correlations among ACTH, beta-LPH and beta-EP concentrations, respectively. These data suggest that beta-LPH and beta-EP were elevated during delivery and in parallel with each other.

Adrenocorticotropic Hormone↗
PubMed1983

Changes of serum gonadotropin levels and sex differences in premature and mature infant during neonatal life.

We measured FSH and LH concentrations by RIA in 130 cord sera and 213 peripheral sera obtained as serially as possible from 67 infants who were 5-75 days old and were born between the 28th and 42nd gestational weeks. Cord serum FSH and LH (+hCG) levels were 3.9-13.6 mIU/ml and 43.3-88.6 mIU/ml, respectively; they decreased with advancing gestational age. Postnatal FSH levels in male infants maintained low levels (3.7-8.7 mIU/ml). However, those in female infants increased with peak levels (51.8-270.3 mIU/ml) between 11 and 30 days after delivery, and then decreased; the surge was more marked and prolonged in preterm infants than in term infants. Postnatal LH levels in both sexes decreased rapidly after birth, which may be due to a decrease of placental hCG, and thereafter displayed patterns similar to FSH levels. We found a significant sex difference of serum gonadotropin levels in newborn infants and differences between term and preterm infants. Our results suggest that the sex difference of pituitary gonadal function exists and that the function matures during the fetal and neonatal life.

Chorionic Gonadotropin↗
PubMed1983

Use of a prosthesis for repair of complete common atrioventricular canal.

From April, 1977 to November, 1979, 5 cases with common atrioventricular canal (Rastelli C-type) underwent surgery, in which the leaflets of both the mitral and tricuspid valves were extended using an auto-pericardium patch in order to control regurgitation. Their ages ranged from one year 3 months to 6 years (mean, 3 years 7 months). One case died on the 37th postoperative day from intracranial bleeding unrelated to the cardiac procedure. In the remaining 4 cases, postoperative examination showed an improvement, and their clinical courses which were followed from 2 years 7 months to 5 years 3 months, were favourable, with only minimal valvular regurgitation remaining in all cases. Although the fate of the pericardium patch must be followed over a long period, this procedure appears to be effective for control of regurgitation in this disease.

Child↗
PubMed1983

Simultaneous measurement of human prolactin and growth hormone levels in maternal and fetal serum and amniotic fluid.

Growth hormone (GH) and prolactin (PRL) in maternal and fetal serum and amniotic fluid were measured simultaneously by radioimmunoassay at term deliveries of 20 normal mothers. The PRL level of amniotic fluid was significantly higher than that of maternal and fetal serum. The fetal GH level was significantly higher than the maternal and amniotic levels of GH. There was no significant correlation among hormone levels of maternal and fetal sera and amniotic fluid. These data suggest that PRL and GH levels of maternal and fetal sera and amniotic fluid are controlled separately.

Amniotic Fluid↗
PubMed1983

The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.

Pregnant Wistar rats were daily injected with 5 mg sulpiride into the peritoneal cavity starting on day 14 of gestation. Blood samples were obtained from the maternal carotid artery and fetal axillary vessels on day 20 of gestation. Serum prolactin (PRL) levels were determined by radioimmunoassay using a rat PRL RIA kit. The maternal serum and fetal plasma PRL levels were significantly higher in the sulpiride-treated group than in the saline control group. There was a significant positive correlation between fetal body weight and fetal plasma PRL level. These results suggest that sulpiride which reached the fetus stimulates fetal PRL secretion and that PRL may exert a growth-promoting effect on the fetus.

Animals↗
PubMed1983

Human plasma ACTH, beta-lipotropin and beta-endorphin during delivery.

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-EP) immunoreactivities were measured by high sensitive radioimmunoassay in maternal and umbilical cord plasma samples which were obtained simultaneously in 12 cases. Mean ACTH levels in cord and maternal plasma were significantly higher than those of 8 normal adults. Mean beta-EP to beta-LPH molar ratio of 0.19 in maternal plasma was different from that of cord plasma (0.13). There was no significant correlation between beta-EP levels, or between beta-LPH levels, in the paired fetal and maternal samples. These data suggest that beta-LPH and beta-EP elevate during labor and delivery in response to the stress. Beta-LPH and beta-EP in cord plasma are of fetal and/or placental origin.

Adrenocorticotropic Hormone↗
PubMed1983

Experimental round window rupture with middle ear effusion.

The effects of laceration of the round window membrane were investigated using the auditory brainstem response in guinea pigs with or without middle ear effusion. Sensorineural hearing impairment occurred in the lower basal turn of the cochlea with middle ear effusion. However, only temporary and mild hearing loss was observed in guinea pigs without middle ear effusion.

Animals↗
PubMed1983

[Case of tinnitus, vertigo, and a loss of caloric response due to neurovascular compression].

The authors report a case of neurovascular compression of the eighth cranial nerve in a 49-year-old businessman. The patient was admitted to the University of Tokyo Hospital because of progressive vertigo and tinnitus on the right without hearing loss over the seven years prior. There were no other symptoms. The general examination was normal. He was neurologically intact except for loss of caloric response. Audiometric studies and brain stem response were normal. The findings of routine hematology, biochemistry, and serology were within normal limits. Tomogram showed that right internal auditory meatus was wider than the left by 2 mm. Computed tomography with metrizamide demonstrated a filling defect in the right cerebellopontine angle. We decided to proceed with exploratory operation with the tentative diagnosis of a left cerebello-pontine angle mass, perhaps neurinoma en plaque meningioma, or epidermoid tumor. Left retromastoid craniectomy with microsurgical exploration of the cerebellopontine angle revealed not a tumor, but a loop of the anterior interior cerebellar artery (AICA) compressing the eighth cranial nerve close to the porus acousticus. A piece of muscle was inserted between the eighth cranial nerve and the AICA. His postoperative course was uneventfull with complete relief of symptoms and without impairment of hearing. In patients with hemifacial spasm and trigeminal neuralgia, neurovascular compression (NVC) has been found at the root entry zone of the facial or trigeminal nerves close to the brain stem at the "junction zone" on the glia and schwann sheath of these nerves.(ABSTRACT TRUNCATED AT 250 WORDS)

Caloric Tests↗
PubMed1983

[A study on testosterone secretion in neonates].

Serum testosterone (T) concentrations in 106 umbilical venous bloods and 104 neonatal venous bloods, which were obtained from preterm (32-36w) and term (36-41w) infants, were measured by RIA. Cord T levels of boys were higher in preterm infants than in term infants, and those of preterm infants were higher in boys than in girls. Neonatal T levels of girls decreased following delivery. But those of boys increased after 10 days of life. T levels were higher in boys than in girls at 11-30 days of life. Differences between preterm and term infants were not significant.

Female↗
PubMed1983

[Studies on the cortisol levels in maternal vein, umbilical artery, and umbilical vein classified according to the mode of delivery].

We measured maternal venous(MV), umbilical arterial(UA), and umbilical venous(UV) cortisol levels of 180 pregnancies at term. In vacuum extraction cases, the cortisol levels of three individual samples were significantly higher than in other modes of delivery. In cesarean section delivery the cortisol levels of three individual samples were the lowest of all modes of delivery. The cortisol level of MV was higher than that of UA and UV in all deliveries. The cortisol levels of three samples showed no difference between the induced labor group and the spontaneous onset of labor group regardless of the delivery mode. In spontaneous vaginal delivery the cortisol levels of three individual samples were significantly higher in primipara than in multipara. Positive correlation was observed in all modes of delivery between the cortisol levels of MV & UA, MV & UV, and UA & UV. There was a negative correlation between the cortisol levels of MV and umbilical arteriovenous cortisol difference in multipara spontaneous vaginal deliveries. There was also a negative correlation between cortisol levels of MV and the umbilical arterial/venous ratio. These data suggest that the fetus may produce cortisol by itself and maternal cortisol may inflow to the fetus.

Female↗
PubMed1983

[Studies on cortisol levels in the maternal vein, umbilical artery, and umbilical vein in cases of fetal distress and neonatal asphyxia].

We measured maternal venous (MV), umbilical arterial (UA) and umbilical venous (UV) cortisol levels of 180 pregnancies at term, and investigated especially cases of fetal distress and neonatal asphyxia. No fetal distress and no neonatal asphyxia cases followed spontaneous vaginal deliveries (94), cesarean sections (18) or breech extractions (6). In cesarean section delivery, the cortisol levels of three individual samples were lower than in other modes of deliveries. The cortisol level of the umbilical artery was significantly higher than that of the umbilical vein in spontaneous vaginal delivery and cesarean section delivery. When spontaneous vaginal deliveries were classified into the fetal distress group and no fetal distress group, the cortisol levels of the umbilical artery and umbilical vein in the former group were significantly higher than those in the latter group. Furthermore, regardless of fetal distress there were significant positive correlations between the cortisol levels of MV & UA, MV & UV, and UA & UV. In addition, as the cortisol level of the maternal vein increased, the umbilical arterial-venous cortisol ratio (UA/UV) gradually approached 1.0. These data suggest that in fetal distress or neonatal asphyxia, the fetus may produce cortisol for itself independent of the mother.

Asphyxia Neonatorum↗