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Biomedical subjects

T Fischer

Publications and source records attributed to T Fischer.

At least 271 records · Page 15Linked to original sources
PubMed1983

Patch testing with sodium tungstate.

Hard metal contains about 90% tungsten carbide. In an investigation of the skin of 853 individuals who are still working or had previously worker in hard metal manufacture, sodium tungstate was included in a patch test with a panel of substances from the environment of the employees. No allergic reactions to tungstate were found. However, irritant pustular reactions appeared in 2.0% of the patch tests. The pustular reactions were often reproducible.

Dermatitis, Contact↗
PubMed1983

Mechanisms of red cell clearance in favism.

Divicine (2,6-diamino-4,5-dihydroxypyrimidine) is a quinoid compound contained in high amounts in all fava bean strains. It elicits a number of metabolic and rheological modifications in G6PD-deficient RBC. Besides this, it stimulates erythrophagocytosis by mouse peritoneal macrophages and formation of crossbonded red cells. The latter are intracellularly membrane-bonded red cells, which form during hypertonic incubation and subsequent swelling. All effects observed in vitro were also observed in vivo in the early phases of fabic hemolysis. In particular, phagocytosis and crossbonding offer a basis for understanding extravasal hemolysis.

Animals↗
PubMed1980

[L. Dopa].

Explore the source record for details and available documents.

Adult↗
PubMed1980

Passive smoking at work.

Air pollution due to tobacco smoke and its effects on employees were investigated in 44 workrooms. For this purpose, the concentrations of CO, NO, NO2, nicotine, and particulate matter were determined, and 472 employees were interviewed about annoyance and irritations. The mean values of the concentrations of the components due to tobacco smoke are: CO = 1.1 ppm, NO = 32 ppb, NO2 = 24 ppb, nicotine = 0.9 micrograms/m3, particulate matter = 133 micrograms/m3. One third of the measured CO values exceeds a critical threshold of 2 ppm CO due to tobacco smoke. One quarter of the persons reports eye irritations at work. One third of the employees qualifies the air with regard to smoke at the workplace as bad. Forty percent of the interviewed persons are disturbed by smoke. The majority of the employees is in favor of a separation into smoking and non-smoking rooms. This seems to be the most appropriate preventive measure for the protection of nonsmokers at work.

Adult↗
PubMed1980

[Passive smoking in the work place].

The air pollution due to tobacco smoke and its effects on employees were investigated in 44 work-rooms. For that purpose the concentration of CO, NO, Nicotine and the Particulate Matter were determined and 472 employees were interviewed about annoyance and irritations. The mean values of the concentrations of the components due to tobacco smoke are: CO = 1.1 ppm, NO = 32 ppb, Nicotine = 0.9 micrograms/m3, Particulate Matter = 133 micrograms/m3. The use of an indicator is discussed. One third of the employees qualifies the air wit regard to smoke at work place as bad. 40% of the interviewed persons are disturbed by smoke. One quarter of th persons indicates eye irritations. The majority of the employees support a separation of the rooms in smoking and non-smoking areas. This seems to be the most appropriate preventive measure for the protection of the nonsmokers at work.

Adult↗
PubMed1980

Aspects of the treatment of mycosis fungoides. A report from the Scandinavian Mycosis Fungoides Study Group.

The Scandinavian Mycosis Fungoides Study Group includes dermatologic clinics in Denmark, Norway, and Sweden. The results of the first three years of activity are presented herein. In plaque stage, topical nitrogen mustard was highly effective. Preceding intravenous tolerance induction seems to be of no value. PUVA induced equally high remission rates. Both modalities were also highly effective in cutaneous tumor stage. In advanced tumor stage and in case of extracutaneous involvement systemic chemotherapy was given. Topical treatment alone was more effective on the cutaneous lesions including tumors than systemic chemotherapy alone. Therefore a combination of topical and systemic treatment is recommended in advanced stages of mycosis fungoides.

Bleomycin↗
PubMed1980

Plasma concentrations after bath treatment and oral administration of trioxsalen.

An analytical method comprising homogenous extraction and determination by gas chromatography mass spectrometry has been developed for the quantitation of trioxsalen in plasma. The limit of sensitivity of the method has been 2 ng/ml of trioxsalen. The method was used to monitor concentrations of trioxsalen in plasma after a 40 mg oral dose or after trioxsalen bath treatment. The concentrations in plasma after oral administration did not exceed 3 ng/ml, while in 2 patients after bath treatment trioxsalen could be determined (2-3 ng/ml). The low plasma concentrations found throw light on the poor UV-sensitizing properties found after oral trioxsalen therapy.

Administration, Oral↗