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Biomedical subjects

T Davies

Publications and source records attributed to T Davies.

106 records · Page 6Linked to original sources
PubMed1969

Studies on the origin of milk fat. A further study of bovine serum lipoproteins and an estimation of their contribution to milk fat.

1. Tritium-labelled palmitic acid combined in olive-oil triglycerides was introduced into the rumen of a lactating cow and the specific radioactivity of the lipids of milk and of the lipoproteins of both jugular and mammary venous serum was measured. 2. As previously found in a similar experiment with [(3)H]stearic acid, the specific radioactivity of the triglyceride fraction of the dextran sulphate-precipitable lipoproteins reached a maximum earlier and greater than that of the milk fat. 3. This fraction was the only lipid separated that had a significant arteriovenous difference in concentration, and is therefore identified as the main circulating lipid precursor of milk fat. 4. Although the non-esterified fatty acids showed no arteriovenous difference in concentration, they showed a negative difference in specific radioactivity that could have occurred only at the expense of the triglycerides of the precipitable lipoproteins. 5. The mean specific radioactivity of the triglycerides immediately after removal from the blood is calculated and shown to be very close in value to that of the corresponding fraction in mammary venous serum. 6. By comparison of the mean specific radioactivities of milk fat and of this precursor, its contribution is calculated as 36%. 7. This value is discussed with reference to the concentration of C(16) and C(18) fatty acids in milk fat and it is concluded that substantial amounts of these acids must have been derived from a source other than preformed circulating lipids.

Animals↗
PubMed1966

An investigation of serum lipoproteins and of their contribution to mild fat in the dairy cow.

1. Tritium-labelled olive-oil triglycerides were introduced into the rumens of lactating cows and the specific activities of the lipids of milk and plasma and of serum lipoproteins were measured. 2. On treatment of serum with dextran sulphate it was found that the lipid of the precipitated beta-lipoproteins consistently had a specific activity-time curve with a maximum comparable in value with, and occurring earlier than, that of the milk fat. 3. On fractionation of the lipids of these lipoproteins it was found that only the triglycerides and diglycerides had specific activity-time curves with maxima greater than that of milk fat, and on radioactivity data alone they are the only blood constituents studied that meet the requirements for being the precursor of milk fat. 4. From a consideration of abundances and the mean specific activities over the period of the experiment it is shown that the contribution of the diglycerides to the radioactivity in the milk fat must have been negligible and that only the triglycerides could have been responsible for all the radioactivity found in it. 5. Although no other fraction could alone have been responsible for all the radioactivity in the milk fat, at least one, the phospholipids, could have made some contribution. 6. It is calculated that 35-48% by weight of milk fat was derived from the beta-lipoprotein triglycerides, according to whether the phospholipids made an improbably large contribution or none at all.

Animals↗
PubMedDate not supplied

Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.

The localization of cellular oncogenes near the break points of tumour-specific chromosomal aberrations suggests an involvement of these genes in the generation of neoplasms. Recently, we demonstrated the translocation of the human cellular homologue (c-ab1) of the transforming sequence of Abelson murine leukaemia virus (A-MuLV) from chromosome 9 to the Philadelphia chromosome (Ph1) in chronic myelocytic leukaemia (CML). In an attempt to investigate the significance of this translocation in the pathogenesis of CML, we have now studied two CML patients with complex translocations, t(9; 11; 22) and t(1; 9; 22), and two CML Ph1-negative patients with apparently normal karyotypes. In addition to using blot hybridization with human c-ab1 probes and DNA from rodent: CML cell hybrids as before, we have used in situ hybridization of these probes directly to metaphase chromosomes of CML patients. These studies show that the c-ab1 gene is translocated in Ph1-positive but not in Ph1-negative CML patients. CML without the Ph1 chromosome seems to be a distinct entity with a different origin, and this view is supported by clinical observations including correlations which reveal a poorer prognosis.

Abelson murine leukemia virus↗
PubMedDate not supplied

Psychological methods of treating hallucinations and delusions: 1.

This article, the first in a two-part series, describes how the neuro-biological, social and environmental factors involved in the course and treatment of schizophrenia have helped to establish a pathway to recovery or remission that does not embrace pharmacological therapy alone. Research into drug-resistant symptoms and poor adherence rates (Curson et al, 1985) demands effective alternatives and additions to more traditional approaches to treatment such as medication. The second part of the article describes how evidence-based psychological interventions were used to help a client suffering from treatment-resistant delusions, allied to a chaotic lifestyle and substance misuse, that had previously presented a substantial challenge to the mental health services.

Adaptation, Psychological↗
PubMedDate not supplied

Hallucinations and delusions. 2: A dual diagnosis case study.

This article, the second of two parts, describes how evidence-based psychological interventions were used to help a client suffering from treatment-resistant delusions and substance misuse, allied to a chaotic lifestyle, that had previously presented a substantial challenge to services. The first part (Vol 8(15): 998-1002) Investigated how the neurobiological, social and environmental factors involved in the course and treatment of schizophrenia have helped to establish a pathway to recovery or remission that does not involve pharmacological therapy alone.

Adaptation, Psychological↗