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Biomedical subjects

T Davies

Publications and source records attributed to T Davies.

At least 91 records · Page 5Linked to original sources
PubMed1984

Photon absorptiometry for non-invasive measurement of bone mineral content.

Bone mineral content of the distal radius was determined in 106 patients by single photon absorptiometry using iodine-125 monochromatic source. The technique provided a reliable means to assess the degree of mineral loss in conditions such as osteoporosis, renal osteodystrophy in patients on chronic maintenance dialysis, subjects on long-term steroid therapy, and those with diabetes mellitus. It is more sensitive than conventional radiography and completely noninvasive compared to bone biopsy. It is suggested that photon absorptiometry is a simple, sensitive, and reliable technique for assessment and follow-up of the bone mineral content in a host of disorders associated with bone demineralization.

Adult↗
PubMed1983

The estimation of fetal haemoglobin in healthy adults by radioimmunoassay.

A radioimmunoassay (RIA) for the measurement of fetal haemoglobin (HbF) was established and used to determine the distribution of HbF in 2463 British adults between the ages of 18 and 65 years. Although a range in HbF values was similar in both genders a shift towards higher values is seen in females and the mean HbF% is higher, in females, at all ages between 18 and 55. A significant and different fall in HbF over the age range studied was noted between females (47%) and males (23%). The difference in mean HbF between the genders was less marked after age 40 years and a small rise in HbF production was measured in females between ages 50 and 54 years.

Adolescent↗
PubMed1981

Magic bullets.

Explore the source record for details and available documents.

Animals↗
PubMed1979

Thyroid stimulating antibodies and metastatic thyroid carcinoma.

A patient with previously treated follicular carcinoma of the thyroid developed Graves' disease with a high titre of thyroid-stimulating antibodies (TSAb). He developed functioning pulmonary metastases leading to hyperthyroidism. Levels of TSAb paralleled the functional status of the metastases suggesting that hyperfunction of the neoplastic tissues was caused by TSAb.

Adenocarcinoma↗
PubMed1976

The effects of therapy with oestriol succinate and ethinyl oestradiol on the haemostatic mechanism in post-menopausal women.

The effects on the haemostatic mechanism of oestrogen therapy, given to prevent bone loss in post-menopausal women, have been investigated. Oestriol succinate was given orally to 10 women at a level of 2 mg/day for 1 month and for a further 3 months with incremental increase of 2 mg each month. 6 of the 10 women were subsequently treated with 25 mug/day orally of ethinyl oestradiol. Oestriol succinate therapy resulted in a small increase in the level of factor VII, a decrease in factor VIII concentration and increased sensitivity of platelets to aggregating agents. Ethinyl oestradiol treatment resulted in much more widespread changes with marked increases in coagulation factors VII, VIII, IX and X, decreased levels of antithrombin and dramatic increases in circulating plasminogen levels and euglobulin lysis activity. The data suggested that the nature of oestrogens employed therapeutically is important in determining the qualitative and quantitative effect of oestrogen therapy on components of the haemostatic mechanism.

Blood Coagulation Factors↗
PubMed1975

Increase in urinary indican excretion in pancreatic steatorrhoea following replacement therapy.

Urinary indican excretion was studied in 5 patients with steatorrhoea of pancreatic origin, 4 patients with steatorrhoea due to other causes, and 5 normal subjects. Treatment with pancreatic extract resulted in an immediate increase in indican excretion to above the normal range in patients with steatorrhoea due to pancreatic insufficiency. Administration of pancreatic extract did not result in a rise in the patients with steatorrhoea not due to pancreatic insufficiency, or in the normal subjects. In one patient with pancreatic insufficiency maintained on a low protein diet, the rise in indican excretion on replacement therapy was much slower and did not reach as high a level as in the patients on a normal protein diet. The possible mechanisms underlying these observations are discussed. It is suggested that the finding of a low indican excretion in the presence of steatorrhoea and its rise to above normal on pancreatic enzyme therapy is strongly suggestive of exocrine pancreatic insufficiency.

Adult↗