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Biomedical subjects

T D Daley

Publications and source records attributed to T D Daley.

At least 55 records · Page 3Linked to original sources
PubMed1987

Surgical suction damage: a common tissue artifact.

The vacuum effect of a surgical suction tip can induce significant artifactual alterations in the connective tissue of specimens removed for diagnostic or therapeutic purposes. The alterations described in this article consist of a surgical suction artifact characterized by the formation of numerous, pleomorphic vacuoles that, on casual microscopic examination, resemble the morphology of traumatized adipose tissue. This artifact occurs when a vacuum draws air into connective tissue and mobilizes connective tissue mucins (acid mucopolysaccharides) that localize within the vacuoles that are formed.

Connective Tissue↗
PubMed1987

Benign migratory glossitis in patients with juvenile diabetes.

The prevalence of tissue type HLA-B15 has been shown to be higher in atopic patients with benign migratory glossitis and in patients with insulin-dependent diabetes mellitus than it is in the general population. Despite this apparent link, the possible relationship between benign migratory glossitis and insulin-dependent diabetes mellitus does not appear to have been investigated previously. This study of 87 diabetic patients and 105 age- and sex-matched nondiabetic control subjects revealed a fourfold increase in the prevalence of benign migratory glossitis in the diabetic group. These results suggest that benign migratory glossitis may be linked to diabetes mellitus and that further investigation of this association is warranted.

Adolescent↗
PubMed1986

Clinical and pharmacologic correlations in cyclosporine-induced gingival hyperplasia.

Cyclosporine-induced gingival hyperplasia was investigated in a clinical study of 100 patients over a period of 2 1/2 years. Seventy percent of the patients exhibited at least mild gingival hyperplasia. For doses within the therapeutic range, no direct correlation was found between the oral dose or the serum trough concentration of cyclosporine and the severity of gingival hyperplasia. The presence of dental plaque was found to be related to the presence of gingival hyperplasia, but only a weak correlation existed between the abundance of plaque and the severity of gingival hyperplasia. Children and especially adolescents had a greater risk of developing cyclosporine-induced gingival hyperplasia than adults had. In 21 patients followed for 1 to 18 months after cessation of cyclosporine therapy, induced gingival hyperplasia was found to be clinically reversible.

Adolescent↗
PubMed1985

Lectin probes of glycoconjugates in human salivary glands: 1.

Research into the oligosaccharide content of glycoproteins in saliva indicates that serous saliva primarily contains N-glycosidically linked carbohydrate chains with high concentrations of mannose, whereas mucous saliva contains a predominance of O-glycosidically linked carbohydrate chains with high concentrations of terminal fucose and N-acetylneuraminic acid molecules. These differences between serous and mucous saliva can be visualized morphologically in salivary gland tissues by differential lectin binding in acinar cells and duct contents. This study utilizes a fluorescein-labelled lectin-binding method to demonstrate these differences and to study the characteristics of ductal and myoepithelial cells in salivary gland tissues. The results generally confirm the predictable differential binding.

Concanavalin A↗
PubMed1985

Lectin probes of glycoconjugates in human salivary gland neoplasms: 2.

Lectins are proteins or glycoproteins which exhibit a high affinity for specific sugar molecules. Terminal sugars on cell surface or cytoplasmic oligosaccharides bound to proteins and lipids can be probed with lectins. This study records the lectin-binding characteristics of 20 salivary gland neoplasms and compares them with observations in normal human serous and mucous salivary glands. The results of this study support the current histogenetic concepts for the development of some of the salivary gland neoplasms.

Adenoma, Pleomorphic↗
PubMed1984

Heterotopic gastric cyst of the oral cavity.

The heterotopic gastric cyst of the oral cavity is a rare lesion. A recurrent gastric cyst in the floor of the mouth of a young female patient is presented. Current theories dealing with the histogenesis of these lesions are presented and discussed. Based on the available embryologic and clinical information, a new histogenetic concept for the development of the heterotopic gastric cyst is proposed.

Adolescent↗
PubMed1984

Hemifacial hypertrophy affecting the maxillary dentition. Report of a case.

A case of hemihypertrophy affecting part of the right maxilla was followed for 8 years with sequential radiographs. The effects of this unusual condition on the developing dentition were documented. Advanced root formation prior to active resorption, increased deposition of secondary dentin, and the histopathologic description of a tooth have not been previously recorded.

Child↗
PubMed1984

Canalicular adenoma: not a basal cell adenoma.

The evidence that canalicular adenomas and basal cell adenomas are separate entities is presented in this article. The clinical features were studied in a series of 13 previously unreported salivary gland tumors (5 canalicular adenomas and 8 basal cell adenomas) and 99 examples derived from the literature (68 canalicular adenomas and 31 basal cell adenomas). Representative tumors from the new cases and from 66 referred cases were studied by histologic, histochemical, and electron microscopic techniques. The two tumors differ significantly with respect to the age range of affected patients, site of predilection, and morphologic and histochemical features.

Adenoma↗
PubMed1984

Epithelial-myoepithelial carcinoma of salivary glands.

Four cases of epithelial-myoepithelial carcinoma of salivary gland origin are presented and discussed. The mean age of these four patients was 68 years, with an age range of 51 to 78 years. Three of the patients were women, and one was a man. This article emphasizes the light microscopic, histochemical, and ultrastructural features of the neoplasm. Electron microscopic examination of glutaraldehyde-fixed fresh tissue and previously formalin-fixed tissue reveals that the characteristic clear cytoplasm of abluminal cells is caused, in part, by glycogen storage granules and the paucity of organelles but largely by an artifact of fixation.

Adenocarcinoma↗
PubMed1984

The canalicular adenoma: considerations on differential diagnosis and treatment.

The canalicular adenoma is an uncommon, benign salivary gland neoplasm that usually occurs in or near the upper lip of elderly patients. A histologic study of 49 tumors revealed that they are often multifocal, may infiltrate their capsule, and are occasionally unencapsulated. Based on these findings, the method of treatment, as well as a differential diagnosis of minor salivary gland lesions, is discussed.

Adenoma↗
PubMed1984

Cyclosporine therapy. Its significance to the periodontist.

Cyclosporine is a relatively new immunosuppressive agent which has been used successfully to prevent organ transplant rejection, to treat type-I diabetes mellitus as well as several other autoimmune disorders. It is anticipated that the therapeutic use of cyclosporine will progressively increase in the future to include the treatment of numerous other disorders. As its clinical use broadens, more health professionals will need to become familiar with the beneficial effects as well as some of the undesirable side-effects of cyclosporine therapy. Two side-effects of the drug which are of interest to the periodontist are gingival hyperplasia and transient perioral hyperaesthesia. It is anticipated that the dental profession, particularly periodontists, will be called upon to help prevent, control or treat these side effects. The purpose of this paper is to familiarize the periodontist with cyclosporine and to discuss its anticipated impact on the practice of periodontics.

Adult↗
PubMed1983

The use of the terms monomorphic adenoma, basal cell adenoma, and canalicular adenoma as applied to salivary gland tumors.

There is considerable confusion in the literature concerning the terms monomorphic adenoma, basal cell adenoma, and canalicular adenoma. This article traces the history of these terms as applied to the pathology of salivary gland tumors and attempts to clarify their usage. It is recommended (1) that monomorphic adenoma be used, as it was originally intended, as a nosologic grouping for all benign epithelial salivary gland tumors that are not pleomorphic adenomas, (2) that basal cell adenoma be used to identify a specific entity that is one component of the monomorphic adenoma group and exhibits a number of histologic subtypes, and (3) that canalicular adenoma be used to describe another entity, distinct from basal cell adenomas but also belonging to the monomorphic adenoma group.

Adenoma↗
PubMed1983

The oral blue nevus: histogenetic implications of its ultrastructural features.

Three cases of oral blue nevus are presented. A comparison of the ultrastructural features of blue nevus cells with those of schwannoma cells indicates that, among other similarities, both exhibit a surrounding external lamina (basement membrane). The significant difference is that blue nevus cells are capable of synthesizing melanin as evidenced by the presence of the entire melanosome maturation sequence within their cytoplasm, a feature not seen in the cells of schwannomas. This fundamental difference suggests that blue nevus cells are more closely related to melanocytes, although they possess some of the characteristics of Schwann cells.

Adult↗
PubMed1983

An unusual parotid tumor with histogenetic implications for salivary gland neoplasms.

This case report describes an unusual parotid salivary gland tumor in which major proliferating elements arise in relation to well-differentiated, branching ducts. Both light and electron microscopic examination indicates that these ducts are formed by two distinct cell layers, an inner row of luminal epithelial cells and an outer layer of modified myoepithelial cells. It is from this outer layer of cells that discrete clusters of uniform basaloid cells develop. Although the majority of basaloid nests were relatively compact, a few showed a small number of clear, slightly widened, intercellular spaces which, ultrastructurally, were lined with basal lamina. Particularly in one area of the lesion, clusters of basaloid cells showed increasing numbers and sizes of these intercellular spaces with the gradual formation of an adenoid cystic pattern of differentiation. Even in this situation, however, luminal epithelial cells forming ducts could still be identified. The bidirectional cellular differentiation, the origin of basaloid clusters in relation to modified myoepithelial cells, and the mode of development of intercellular spaces resulting in an adenoid cystic pattern all have important implications for the histogenesis of salivary gland tumors.

Adenoma↗