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Biomedical subjects

T D Daley

Publications and source records attributed to T D Daley.

At least 37 records · Page 2Linked to original sources
PubMed1993

Intraoral sebaceous hyperplasia. Diagnostic criteria.

Surprisingly little is understood about the physiologic and pathologic processes that involve intraoral sebaceous glands. Neoplasms are rare. Hyperplasia of these glands is undoubtedly more common, but criteria for the diagnosis of intraoral sebaceous hyperplasia have not been established. These lesions are too often misdiagnosed as large "Fordyce granules" or, when very large, as sebaceous adenomas. On the basis of a series of 31 nonneoplastic sebaceous lesions and on published data, the following definition is proposed: intraoral sebaceous hyperplasia occurs when a lesion, judged clinically to be a distinct abnormality that requires biopsy for diagnosis or confirmation of clinical impression, has histologic features of one or more well-differentiated sebaceous glands that exhibit no fewer than 15 lobules per gland. Sebaceous glands with fewer than 15 lobules that form an apparently distinct clinical lesion on the buccal mucosa are considered normal, whereas similar lesions of other intraoral sites are considered ectopic sebaceous glands. Sebaceous adenomas are less differentiated than sebaceous hyperplasia.

Adenoma↗
PubMed1993

Focal epithelial hyperplasia (Heck's disease) with generalized lesions of the gingiva. A case report.

Focal epithelial hyperplasia is an uncommon benign oral condition that occurs mainly in young individuals of certain racial groups. The lesions most commonly affect the mucosal surfaces of the lips and they have been observed frequently to regress within a few months. This is a report of an unusual case of focal epithelial hyperplasia in a young black adult presenting with generalized involvement of the gingiva. There is no clinical evidence of regression of the lesions and the case remains similar to the original appearance 2 years after diagnosis. The diagnosis and management of focal epithelial hyperplasia are discussed.

Adult↗
PubMed1992

Palisaded encapsulated neuroma of oral mucosa.

The palisaded encapsulated neuroma is a solitary, small peripheral nerve lesion that occurs primarily on the facial skin of middle-aged adults. We report a series of 13 cases of palisaded encapsulated neuroma occurring on oral mucosa. The lesions presented as solitary, firm, sessile, partly or completely encapsulated, 2 to 3 mm nodules in adults with a mean age of 51 years (median 55 years). Nine of the neuromas occurred on the hard palate; the remainder were found on the soft palate, lower lip mucosa, upper lip mucosa, and maxillary anterior alveolar ridge. None of the cases was associated with neurofibromatosis or multiple endocrine neoplasia syndrome type III. Microscopically, the tumors were characterized by a moderately cellular, fascicular proliferation of spindle cells that showed some areas of nuclear palisading, suggestive of schwannoma. Immunohistochemical stains revealed that the lesions were composed largely of S-100 protein-positive Schwann cells and variable numbers of peripheral nerve axons, which were identified by their positive neurofilament staining. The fibrous capsule of the lesions showed positive staining for epithelial membrane antigen, indicative of perineurium.

Adult↗
PubMed1992

Langerhans' cell histiocytosis in association with periapical granulomas and cysts.

This report describes a series of six cases of inflammatory periapical disease with small aggregates of Langerhans cells as a minor component. Immunohistochemical findings confirm that the cells are phenotypically related to Langerhans cells. Aggregates of these cells are not normally found in radicular cysts or periapical granulomas and have been interpreted to represent chronic localized Langerhans' cells histiocytosis. Whether these lesions, which arise within the context of chronic inflammatory periapical disease, represent incipient eosinophilic granulomas or are a more benign, minimally destructive form of Langerhans' cell histiocytosis is unknown. Clinical follow-up suggests that these lesions remain localized and that curettage is adequate treatment.

Adult↗
PubMed1992

Oral pathology in Canada: a survey.

The Canadian Academy of Oral Pathology conducted a survey of its active members to obtain information on their demographics, professional activities and university affiliations, and to assess Canada's present and future oral pathology needs. Data were also collected on Canadian oral pathology diagnostic biopsy services. This paper reports the salient findings of the survey, and discusses their implications for the specialty of oral pathology as well as for the Canadian dental community.

Adult↗
PubMed1991

Pregnancy tumor: an analysis.

There is some disagreement about the validity of the clinical term "pregnancy tumor." On the basis of its clinical presentation and histologic appearance, some authors believe that it simply represents a pyogenic granuloma (PG), whereas others believe that the lesion is unique because of the apparent influence of female sex hormones. In an attempt to resolve this problem, a study was undertaken to determine whether a significant correlation exists between PG and pregnancy, and whether the clinical term applies to the other epulides. The study involved 42 epulides diagnosed clinically as pregnancy tumors. A chi-square analysis comparing 32 of these lesions with 757 epulides occurring in women revealed a significant disproportion in the number of PGs, whereas the number of peripheral ossifying fibromas and peripheral giant cell granulomas were within the expected range. Very few focal fibrous hyperplasias (fibromas) were diagnosed as pregnancy tumors. Clinical and behavioral features of pregnancy tumors diagnosed microscopically as PGs were also analyzed. The results indicated that the diagnosis of pregnancy tumor is valid clinically in describing a PG occurring in pregnancy, because it describes a distinct lesion not on the basis of histologic features but on etiology, biologic behavior, and treatment protocol.

Adolescent↗
PubMed1991

Orthodontic therapy in the patient treated with cyclosporine.

Cyclosporine is an immunosuppressive drug that is gaining widespread use in the treatment of a variety of disorders. Gingival hyperplasia, a common side effect of cyclosporine therapy, has significant implications for orthodontic treatment, especially as the drug becomes more widely used to treat diseases prevalent in adolescents. A 5-year study of a group of patients with type 1 diabetes who were receiving cyclosporine treatment revealed a series of findings that are of importance to the orthodontist, including the potential for orthodontic appliances to increase the severity of the induced gingival enlargement and the potential of the gingival hyperplasia to complicate orthodontic therapy. Guidelines to minimize the degree of cyclosporine-induced gingival enlargement in the orthodontic patient are suggested.

Adolescent↗
PubMed1991

Heat generated by grinding during removal of ceramic brackets.

When ceramic brackets fracture during treatment or at the time of debonding, it may become necessary to remove residual fragments by grinding with a handpiece. However, the grinding of ceramic surfaces may generate temperatures high enough to have detrimental effects on dental pulp. Intrapulpal temperature measurements were made on extracted teeth during bracket grinding with a small thermocouple probe fixed to the pulpal wall subjacent to the bracket position. These measurements were then compared with established threshold temperatures that have been reported to cause pulpal pathosis. We removed 122 ceramic brackets (A-Company Starfire, GAC Allure, and Unitek Transcend) from eight extracted teeth by grinding with high-speed diamond burs or low-speed green stones, both with and without air or water coolant. It was determined that low-speed grinding without coolant resulted in a significant (p less than 0.001) increase in pulp chamber temperature for all three types of brackets. Neither high-speed nor low-speed grinding during bracket removal caused a rise in pulp chamber temperature when combined with air or water coolant.

Adolescent↗
PubMed1991

Factors associated with increased frequency of HIV-related oral candidiasis.

HIV-related oral candidiasis was investigated in 71 HIV-seropositive patients who received interviews, oral examinations and hematologic investigation. Diagnosis of candidiasis was based on clinical signs and examination of PAS-stained smears. The frequency of candidiasis was 24/71 (34%). The clinical presentations were pseudomembranous 8 (11%), erythematous 14 (20%), angular cheilitis 3 (4%). Twenty-six patients (37%) had candidiasis or were receiving antifungal treatment for recurrent pseudomembranous type. Twelve of 13 (92%) patients with AIDS and 14/58 (24%) without AIDS were affected. Bivariate analyses showed significant associations with AIDS, the use of zidovudine, low T4-count, xerostomia; marital status (sometime married), restricted performance status and age of greater than 35 yr. Multivariate logistic regression analysis showed that the presence of xerostomia was an independent and statistically significant predictor of HIV-related oral candidiasis. T4-count and restricted performance status were the second and third most important predictors.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Diseases of the salivary glands: a review.

The normal function of major salivary glands as well as thousands of minor ones is an important determinant of oral health. Many diseases of these glands are common, yet not often appreciated by the dentist or his staff. This paper reviews common and some less common diseases of salivary glands, including developmental, hypertrophic, reactive, autoimmune and neoplastic conditions.

Cytomegalovirus Infections↗
PubMed1990

X-ray microanalysis of teeth from healthy patients and patients with familial hypophosphatemia.

Energy-dispersive X-ray microanalysis was used to determine calcium/phosphorous (Ca/P) ratios in undecalcified teeth, and the sulfur (S) content of dentin of decalcified teeth from normal patients and patients with familial hypophosphatemia, in an attempt to determine the effect of phosphorus deficiency. The results showed that normal enamel has a slightly elevated Ca/P ratio compared to pure apatite. Enamel from a tooth of an untreated patient with hypophosphatemia exhibited a significantly higher Ca/P ratio than the normal teeth whereas enamel from teeth of an intermittently treated patient exhibited Ca/P ratios similar to pure apatite. Surprisingly, globular dentin in the same teeth showed a Ca/P ratio similar to that of globular dentin of the untreated tooth. The decalcified dentin from teeth of three hypophosphatemic patients and eight normal patients showed a S peak which varied widely in concentration. No detectable differences could be found between normal and diseased teeth.

Adolescent↗
PubMed1990

Practical applications of energy dispersive X-ray microanalysis in diagnostic oral pathology.

Energy dispersive X-ray microanalysis is a powerful tool that can reveal the presence and relative quantities of elements in minute particles in biologic materials. Although this technique has been used in some aspects of dental research, it has rarely been applied to diagnostic oral pathology. The purpose of this paper is to inform practicing dentists and oral specialists about the diagnostic potential of this procedure by presenting three case reports. The first case involved the identification of flakes of a metallic material claimed by a 14-year-old girl to appear periodically between her mandibular molars. In the second case, a periodontist was spared a lawsuit when a freely mobile mass in the antrum of his patient was found to be a calcium-phosphorus compound not related to the periodontal packing that had been used. The third case involved the differential diagnosis of amalgam tattoo and graphite tattoo in a pigmented lesion of the hard palate mucosa. The results of the analyses were significant and indicate a role for this technique in the assessment of selected cases. Potential for wider use of energy dispersive X-ray microanalysis in diagnostic oral pathology exists as research progresses.

Adolescent↗
PubMed1990

Foreign body gingivitis: an iatrogenic disease?

Gingival biopsy specimens from eight patients exhibiting a localized, erythematous, or mixed erythematous/leukoplakic gingivitis that was refractory to conventional periodontal therapy were examined histologically and by energy-dispersive X-ray microanalysis. Histologic examination revealed variable numbers of small, usually subtle, sometimes equivocal, and occasionally obvious foci of granulomatous inflammation. Special stains for fungi and acid-fast bacilli were consistently negative. In all cases, the granulomatous foci contained particles of foreign material that were often inconspicuous and easily overlooked during routine histologic examination. Energy-dispersive X-ray microanalysis of these foreign particles disclosed Ca, Al, Si, Ti, and P in most lesions. However, other elements such as Zr, V, Ag, and Ni were found only in specific biopsy specimens. By comparing the elemental analyses, clinical features, and history of the lesions, strong evidence for an iatrogenic source of the foreign material was found in one case, and good evidence in five cases. In the remaining two patients, the source of the foreign particles remains unresolved.

Adult↗
PubMed1990

Common acanthotic and keratotic lesions of the oral mucosa: a review.

White lesions of the oral mucosa are common. Dentists must be aware of the diseases that can cause these lesions, the terminology used to describe them histologically, and their significance to the patient. This paper represents a review of basic terminology and a brief description of common acanthotic and/or keratotic lesions of the oral mucous membranes.

Humans↗
PubMed1990

The major epulides: clinicopathological correlations.

The word "epulis" is a clinical term used to describe a localized growth on the gingiva. Histologic examination of epulides indicates that the vast majority are focal fibrous hyperplasias, peripheral ossifying fibromas, pyogenic granulomas or peripheral giant cell granulomas. Data, derived from a 12-year retrospective study of gingival lesions submitted to the Oral Pathology Diagnostic Service at The University of Western Ontario, are the subject of this paper. The results indicate that the major epulides are common oral lesions with which dentists should be thoroughly familiar. The histologic features and clinical relevance of these lesions are examined and analyzed and their biological and clinical behavior are discussed.

Adolescent↗
PubMed1988

Herpes simplex virus type 1 proteins in human oral squamous cell carcinoma.

Although considerable evidence has accumulated linking herpes simplex virus (HSV) to carcinoma of the uterine cervix, only fragmentary evidence exists linking HSV to oral cancer. The purpose of this study was to search for HSV type 1 (HSV-1) proteins in tissue sections of 132 oral squamous cell carcinomas and 56 age- and site-matched controls. All tissues were incubated in rabbit anti-HSV-1 serum with the use of a modified direct immunoperoxidase technique. More than 42% of the cancers, but none of the controls, reacted positively. Thirteen selected oral carcinomas that exhibited positive polyclonal staining were incubated with the use of a peroxidase-antiperoxidase technique with a mouse monoclonal antibody raised against the 89 kilodalton HSV-1 envelope protein. None of these tissues exhibited a positive reaction. Similarly, no unequivocal ultrastructural viral particles were found in 11 oral carcinomas that stained positively with the polyclonal antibodies. These results are interpreted to indicate partial expression of a noninfectious viral genome. The presence of this genome in a high proportion of lesions in this study lends strong statistical support to the oncogenic relationship between HSV-1 and oral squamous cell carcinoma.

Carcinoma, Squamous Cell↗