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Biomedical subjects

T D Chugh

Publications and source records attributed to T D Chugh.

At least 73 records · Page 4Linked to original sources
PubMed1983

Drug resistance among Salmonellae in Kuwait.

The status of drug resistance among Salmonella spp. prevalent in Kuwait during 1979-1980 has been assessed. Antibiotic sensitivity of 345 clinical isolates against 14 antimicrobial agents was done by disc-diffusion technique and their MIC was determined by plate dilution. Only 9.6% of these isolates were sensitive to all the 14 drugs. There was resistance to sulfisoxazole (78%), tetracycline (69%), kanamycin (61%), ampicillin (56%), streptomycin (53%), chloramphenicol (38%) and mezlocillin (38%). Multiple drug resistance (three or more drugs) was seen in 71% of isolates and many of them were resistant to five or more drugs. The common resistance patterns observed were ACGKSSuT, ACKSSuT, ACSSuT, and ASSuT. Co-trimoxazole was the drug of choice as only 15 strains (4%) were resistant to it. The minimum inhibitory concentration (MIC) of the resistant strains was invariably high. Salmonella typhimurium was the commonest (41%) single species and the frequency and level of resistance was higher in this serotype than in others.

Anti-Bacterial Agents↗
PubMed1982

Plasmid-linked drug resistance in Salmonella typhimurium in Kuwait.

A total of 143 strains of S. typhimurium isolated from clinical cases in Kuwait were investigated for drug resistance. Multidrug resistance (3 or more drugs) was seen in 76.9% of the strains. The common resistance patterns were ASuT (16), AKSuT (20), ASSuT (14), CKSSuT (14), ACKSSuT (10), ACGKSSuT (15) and ACKGSSuTTm (8). MIC of resistant strains was usually high. Sixteen isolates were examined for the transferability of the resistance. All had R-plasmids, both autotransferable and non-autotransferable which could be mobilised by factor X.

Anti-Bacterial Agents↗