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Biomedical subjects

T Chujo

Publications and source records attributed to T Chujo.

67 records · Page 4Linked to original sources
PubMed1978

Neuronal mechanisms of the late N-wave induced in vitro in thin sections of the olfactory cortex of rats.

Experiments were done to elucidate properties of the late N-wave which was induced in vitro in thin sections of the olfactory cortex of the rat in response to stimulation of the lateral olfactory tract. The late N-wave decreased in size at a stimulation rate of more than once every 90 sec or at temperatures higher than 27 degrees C. The late N-wave was suppressed in the presence of GABA, picrotoxin or bicuculline or in the Cl-free medium. Penicillin or pentylenetetrazol, which blocked actions of GABA on the presynaptic potential, also suppressed the late N-wave. The late N-wave first appeared at postnatal ages of 18--25 days. The late N-wave reversed in polarity when recorded from the deep layers of the sections or from the cut surface of the sections. Single cells in the deep portions of the sections discharged during the late N-wave. Cells in the superficial layers fired just before or after the late N-wave. In order to explain these observations, a neuronal model for generation of the late N-wave was presented.

Action Potentials↗
PubMed1977

Inhibition and excitation induced by glutamic acid on cerebellar interneurons.

Thin sections of guinea pig cerebellum were incubated in an artificial medium and responses of neurons in the granular layer to glutamic acid were studied. About half of these neurons were inhibited by glutamate administered electrophoretically (GI cells) and others were excited (GE cells). The GI cells were also inhibited in a medium containing glutamate. Gamma-amino butyric acid inhibited the GI as well as the GE cells. The inhibition in the GI cells induced by glutamate was not susceptible to picrotoxin or strychnine medication, and was not blocked in a CI-free medium or in a medium containing CA2+ in low concentrations and Mg2+ in high concentrations. Some GI cells showed high-amplitude spikes which were recordable at distances of tens of micrometer from the cell. These observations indicate that at least some of the GI cells were large Golgi cells and that the inhibition induced by glutamate in the GI cells was not mediated by inhibitory interneurons.

Action Potentials↗
PubMed1976

Analysis of serum immunoglobulins in hereditary sensory radicular neuropathy.

Serum and salivary immunoglobulins were studied in 11 members of a family including 3 patients with hereditary sensory radicular neuropathy (HSRN) in 1 of whom serum immunoglobulins were measured over a period of about 6 years. It was confirmed that serum IgA and IgG levels rose as the disease progressed. Although our results do not agree, in part, with the findings of Whitaker et al. (1974) who reported an increase in IgA alone, the present study suggested that such dysimmunoglobulinaemia deserves further study. Whether dysimmunoglobulinaemia is a primary phenomenon related to the development of HSRN or simply a secondary change remains to be further explored.

Adolescent↗
PubMed1975

Sensitivity of Purkinje cell dendrites to glutamic acid.

The distribution of glutamate sensitive site was studied in vitro in thin cerebellar sections from guinea-pigs, in which Purkinje cell bodies and some of the principal dendrites were identified microscopically. Glutamate administered near the cell body induced firing. Stronger excitation, however, was produced when glutamate was administered to the molecular layer along a strip of tissue extending from the soma of the cell under study towards the pial surface of the slice. Excitation induced by glutamate slowly declined in some cells during prolonged administration. D-Glutamate was a weaker excitant than the L-isomer. These results suggest that the dendrite of the Purkinje cell is more sensitive to glutamate that the cell soma.

Animals↗