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Biomedical subjects

T C Jones

Publications and source records attributed to T C Jones.

At least 73 records · Page 4Linked to original sources
PubMed1982

Grant writing.

Explore the source record for details and available documents.

Nursing↗
PubMed1981

Response of babesiosis to pentamidine therapy.

Three nonsplenectomized patients were infected with Babesia microti. One had fever, abdominal pain suggesting gallbladder disease, and evidence of disseminated intravascular coagulation; another was considered to have lymphoma, partly because two smears for Babesia before admission were negative. All three patients were treated with pentamidine isethionate and improved clinically. Parasites were no longer seen on smears after 5 days of therapy, but Babesia could still be recovered by hamster inoculation 5 weeks after therapy in one of the patients tested, underscoring the need for this test to properly evaluate eradication of the organism. In one patient, pentamidine was stopped after 7 days because of increased creatinine concentration, and this amount of drug appeared adequate to control the parasitemia. Pain at drug injection sites was a major side effect in all three patients. Pentamidine appears to be useful in controlling clinical manifestations of babesiosis and decreasing parasitemia, but it does not eradicate the organism.

Aged↗
PubMed1981

Interactions between murine macrophages and obligate intracellular protozoa.

The diversity of interactions between obligate intracellular protozoa and murine macrophages is just being elucidated. Protozoa of the genera Toxoplasma, Leishmania, and Trypanosoma all enter and replicate within macrophages. This review describes similarities and differences among these organisms with regard to entry mechanisms, sites of replication in the phagolysosomal system, metabolic requirements, effects on macrophage function, macrophage handling of protozoal antigens, the relationship to genetics of immune response, and the characteristics of lymphokine-induced microbicidal and microbistatic processes. These organisms each enter the macrophage by endocytosis, but they then reside at different sites in relation to the phagolysosomal system. The basis of obligate parasitism remains unknown; however, both the protozoa and the host cell have important effects on the function of the other during parasitism. The macrophage may play a pivotal role in the immunosuppression associated with the early stages of infection by each of these microbes. Genetic influences on the response to infection have been clearly identified in murine models. Lymphocyte products from immune cells have marked effects on the interactions of protozoa and macrophages, under some conditions stimulating protozoacidal mechanisms, and in some protozoastatic responses. The dynamic balance between protozoal parasitism and macrophage response must be further defined in order to determine the potential value of chemotherapeutic or immunologic intervention.

Animals↗
PubMed1980

Serologic diagnosis of acute lymphadenopathic toxoplasmosis.

The diagnosis of acute toxoplasmosis usually depends on serology, yet little data are available to compare the relative usefulness of various serologic tests after the onset of illness. The Sabin-Feldman dye test (DT), the IgM immunofluorescent antibody (IgM-IFA) test, the soluble antigen complement-fixation (CF) test, and the indirect hemagglutination (IHA) test were performed on serial serum specimens from 27 previously healthy patients, each of whom could identify the date of onset of illness within two weeks. IgM-IFA titers of greater than or equal to 1:160 were the best indicators of infection acquired in the past two to four months. The DT was useful for screening, but two-tube rises in titer were rarely documented, and absolute titers were imprecise indicators of the recentness of infection. Although two-tube rises in titer in CF and IHA tests could be seen in the majority of patients, the rises were so slow that both tests were less useful than the IgM-IFA test in documenting the diagnosis of acute toxoplasmosis.

Acute Disease↗
PubMed1979

Autonomic neuropathy in rheumatoid arthritis.

Patients with seropositive and seronegative rheumatoid arthritis (RA) and age-matched controls were investigated for the presence of autonomic neuropathy. Significantly more patients with RA had abnormal autonomic function, suggesting that autonomic neuropathy occurs more commonly in RA than hitherto suspected. The existence of an autonomic neuropathy may be an important complicating factor in rheumatoid disease and may lead to increased morbidity and mortality.

Adult↗
PubMed1979

Eosinophilia, elevated immunoglobulin E level and chronic enteritis due to intestinal helminthiasis.

Recurrent urticaria, abdominal pain, peripheral eosinophilia, hyperimmunoglobulin E and small bowel abnormalities on roentgenograms prompted evaluation of a 36 year old man for intestinal parasitism. Evidence for helminthiasis as the cause of his symptoms included changing antibody titers to helminth antigens and a dramatic response to therapy. Helminth larvae or eggs were not recovered. Diagnosis of strongyloidiasis, the most likely cause of the illness, is discussed.

Adult↗
PubMed1978

The interaction in vitro of Pneumocystis carinii with macrophages and L-cells.

A model was developed for studying the interaction between Pneumocystis, rat-derived cells, and humoral factors. Pneumocystis were obtained in large quantity by bronchial lavage of steroid-treated rats. The trophozoite was the predominant form obtained, and it could readily be recognized by phase contrast microscopy. Organisms maintained a typical morphology for at least 3 days in culture, and 10-20% took up radiolabeled nucleotides. Pneumocystis readily adhered to cell surfaces in a similar manner in alveolar macrophages from steroid-treated or normal rats, mouse peritoneal macrophages, and L-cells. Adherent organisms were not interiorized to a significant degree in the absence of antipneumocystis serum. After addition of rabbit antipneumocystis serum, rapid interiorization of organisms occurred from the surface of macrophages but not L-cells. Organisms appeared to be promptly destroyed within macrophages after interiorization. Persisting or multiplying intracellular forms were not seen. Antipneumocystis serum did not morphologically alter Pneumocystis. These observations suggest a role for antibody and mononuclear phagocytes during the immune response to Pneumocystis.

Animals↗
PubMed1978

Outbreak of toxoplasmosis in a family and documentation of acquired retinochoroiditis.

An outbreak of toxoplasmosis in one household is described. It demonstrates the potential for a common source infection with Toxoplasma gondii to cause multiple cases. Six of seven members of a household investigated for toxoplasmosis demonstrated high antibody titers consistent with recent infection; five of these members (83%) were symptomatic. The most common manifestations were fever and lymphadenopathy, which developed from seven to 18 days (mean 11 days) after a common source ingestion of infected meat. Since inadequately cooked lamb, pork and beef are probably the most common sources of infection in the United States, outbreaks of multiple cases may occur more frequently than is generally appreciated. As more outbreaks of febrile illnesses are examined, especially in families and closed communities, it is likely that more common source epidemics of toxoplasmosis will be recognized. Retinochoroiditis is an unusual manifestation of adult acquired toxoplasmosis. In the index case in this epidemic the patient manifested vision threatening retinochoroiditis 129 days after infection with toxoplasmosis. He represents the ninth well-documented case of toxoplasma retinochoroiditis associated with adult acquired disease.

Adolescent↗
PubMed1978

Chromosome banding patterns and nucleolar organizing regions in three species of Callithricidae (Saguinus oedipus, Saguinus fuscicollis, and Callithrix jacchus).

Chromosome complements of three species of Callithricidae, Saguinus oedipus, Saguinus fuscicollis and Callithrix jacchus, were analyzed by various banding techniques. Morphometric data are presented. A diploid chromosome number of 2n = 46 is reconfirmed for all three species. Several interesting interspecies chromosomal variations were demonstrated by G- and C-band patterns. Active nucleolar organizing regions (NORs) were revealed by the Ag-AS silver histochemical stain.

Animals↗