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Biomedical subjects

T Bando

Publications and source records attributed to T Bando.

At least 127 records · Page 7Linked to original sources
PubMed1991

Cerebral cortical and brainstem areas related to the central control of lens accommodation in cat and monkey.

1. Studies on the central nervous system related to lens accommodation in cat and monkey were reviewed. 2. During the last decade, a considerable amount of neurophysiological data on the peripheral innervation of the ciliary muscle, properties of parasympathetic oculomotor neurons and mesencephalic reticular neurons have accumulated. 3. Neurophysiological and anatomical evidence supporting the contribution of the cerebellum to lens accommodation has been obtained. 4. Recently, cerebral cortical neurons in the parieto-occipital cortex with activities related to lens accommodation were found in cat and monkey.

Animals↗
PubMed1991

A projection of the lens accommodation-related area to the pupillo-constrictor area in the posteromedial lateral suprasylvian area in cats.

The fiber connection between areas related to lens accommodation and to pupillary constriction was studied in the posteromedial lateral suprasylvian area (PMLS) in the extrastriate cortex of the cat. The accommodation-related area was located in the PMLS by microstimulation, and the anterograde tracer Phaseolus vulgaris leucoagglutinin was injected into this area. Anterogradely-labeled fibers and terminals were found in the upper part of the medial bank of the middle suprasylvian sulcus, the area corresponding to the pupillo-constrictor area in the PMLS. The labeling was also found in the fundus of the middle suprasylvian sulcus, the medial bank of the lateral sulcus and the superficial layers of the superior colliculus. It is concluded that the area related to lens accommodation projects to the area related to pupillary constriction in the PMLS.

Accommodation, Ocular↗
PubMed1990

Induction of cells with phenotypic features of neuronal cells by treatment with dibutyryl cyclic adenosine 3',5'-monophosphate in a human parotid gland adenocarcinoma cell line in culture.

A human parotid gland adenocarcinoma cell line, with an intercalated duct cell phenotype of the salivary gland and expression of vasoactive intestinal polypeptide and amylase, was cultivated in the presence of dibutyryl cyclic adenosine 3',5'-monophosphate (dB-cAMP). Morphological changes occurred; cells formed long cytoplasmic processes densely packed with ample microfibrils, as well as microtubules, and grew in a netlike appearance. In addition, it has been found by the immunofluorescence staining technique, immunoblotting, or immunoelectron microscopy that the cells treated with dB-cAMP express neurofilaments, neuron-specific enolase, synaptophysin, and HNK-1 antigen, as well as the alpha- and beta-chains of tubulin, whereas these antigens are not detected in untreated cells. The expression of vasoactive intestinal polypeptide detected diffusely in the cytoplasm of untreated cells was restricted to the cell membranes during the cultivation of cells in the presence of dB-cAMP, while expression of amylase persisted in the treated cells in a fashion similar to that in untreated cells. Moreover, both anchorage-independent and anchorage-dependent growth of the cells was markedly suppressed in the presence of dB-cAMP. After removal of dB-cAMP from the culture, the treated cells returned rapidly to the phenotype and growth rate of the untreated cells. These findings indicate that reversible conversion into cells with phenotypic features of neuronal cells of a human parotid adenocarcinoma cell line occurs in growth medium containing dB-cAMP.

Adenocarcinoma↗
PubMed1989

Projections of the postero-medial lateral suprasylvian area (PMLS) to cortical area 20 in cats with special reference to pupillary constriction: a physiological and anatomical study.

Projections of the pupillo-constrictor area in the postero-medial lateral suprasylvian area (PMLS) to that in cortical area 20 was studied using electrophysiological and anatomical methods. Cats were injected with wheatgerm agglutinin-conjugated horseradish peroxidase in the latter area, which was located by intracortical stimulation. Retrogradely labeled cells were found in the PMLS pupillo-constrictor area. It was concluded that the pupillo-constrictor area in the PMLS has direct projections to that in area 20.

Animals↗
PubMed1989

Solubilization and characterization of a ouabain-sensitive protein from transverse tubule membrane-junctional sarcoplasmic reticulum complexes (TTM-JSR) in cat cardiac muscle.

A new glycoprotein of 31,500 dalton, which has a high affinity for ouabain, and is independent of (Na+-K+)-ATPase, was solubilized from transverse tubule membrane and junctional sarcoplasmic reticulum complexes (TTM-JSR) of cat cardiac muscle. This protein could be extracted only in small amounts from sarcolemma-plasma membrane (SLM-PL) fragments, suggesting that it indeed originates from the TTM-JSR.

Animals↗
PubMed1989

Uptake of [3H]dopamine in the mouse adrenal medulla during dark and light period.

Uptake of exogenous [3H]dopamine in adrenal chromaffin cells of the mouse was studied by autoradiography under a 12-h light, 12-h dark cycle. The uptake of [3H]dopamine in adrenal chromaffin cells was markedly decreased in the dark period. The decrease was prevented by adrenal denervation. It is postulated that there is a neurally mediated suppression of [3H]dopamine uptake by adrenal chromaffin cells in the dark period. Adrenaline-storing (A) cells are more sensitive to the decreased sympathetic activity than noradrenaline-storing (NA) cells while increased sympathetic activity non-selectively affects both types of adrenal chromaffin cells.

Adrenal Medulla↗
PubMed1988

Effect of indomethacin on febrile response to recombinant human interleukin 1-alpha in rabbits.

Effects of indomethacin, a potent inhibitor of prostaglandin (PG) synthesis, on the fever induced by recombinant human interleukin 1-alpha (rhIL 1-alpha) was studied in conscious rabbits. Intracerebroventricularly administered rhIL 1-alpha induced a dose-dependent increase in colonic temperature that was prominently suppressed by pretreatment with indomethacin given either intracerebroventricularly or subcutaneously. On the other hand, fever induced by intravenous administration of rhIL 1-alpha was not completely suppressed by either subcutaneous or intracerebroventricular indomethacin; a small rise in colonic temperature persisted at approximately 45 min after rhIL 1-alpha injection. This rise in colonic temperature was suppressed when indomethacin was given both intracerebroventricularly and subcutaneously. It is suggested that PGs synthesized in the central nervous system contribute to the IL 1 fever and that part of IL 1-alpha given peripherally is also transmitted into the central nervous system to contribute to IL 1 fever.

Animals↗
PubMed1988

[A case report of carcinoid of the rectum coexisting with adenocarcinoma in a single lesion].

A 69-year-old female, chiefly complaining of diarrhea, was admitted to the Toyama Medical & Pharmaceutical University Hospital. A barium enema and an endoscopic examination revealed a villous adenocarcinoma of the rectum. Computerized tomography disclosed multiple metastatic lesions in the liver. She underwent an amptatio recti and an intra-arterial cannulation of the common hepatic artery in order to administer anticancer agents. Gross findings of the resected specimen showed villous adenocarcinoma containing a small ulcerated lesion. Histologic findings of this lesion revealed a collision neoplasm containing both an adenocarcinoma and a carcinoid with no obvious transitional region between the two lesions. The type D carcinoid, determined according to Soga's histologic classification, showed positive argyrophil granules but no argentaffin granules in the cytoplasm. The electron-microscopic findings of the carcinoid revealed small electron-dense endocrine granules measuring about 150 approximately 300 nm in diameter. The woman died 4 months after this operation.

Adenocarcinoma↗
PubMed1987

Depressant effect of cooling of the postero-lateral occipital cortex on pupillo-constriction responses evoked from the lateral suprasylvian area in cats.

In anesthetized cats, the postero-lateral occipital cortex corresponding to area 20 was temporarily cooled. Pupillary constriction responses evoked from the middle part of the ipsilateral lateral suprasylvian area (the PMLS of Palmer et al.) decreased by about 50% in amplitude during cooling. These results demonstrate a functional liaison between area 20 and the PMLS.

Animals↗
PubMed1986

An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen.

A neoplastic epithelial cell line, TYS, was isolated from a well-differentiated squamous cell carcinoma expressing carcinoembryonic antigen (CEA) that arose in human oral mucosa. Expressions of CEA and amylase as well as ample tonofilaments were detected in cultured TYS cells. Transplantation of the cells into athymic nude mice resulted in production of adenoid squamous cell carcinoma containing CEA and amylase. Cultivation of TYS cells in the presence of sodium butyrate resulted in suppression of cell growth and production of secretory granules with amylase in the cytoplasm of the cells. When the sodium butyrate-treated cells were transplanted into nude mice, a small mass developed transiently at the inoculation site and then disappeared. This mass was histopathologically interpreted as acinic cell carcinoma with squamoid lesion. These findings suggest that we have established a human adenoid squamous carcinoma cell line presumably derived from a minor salivary gland present in oral mucosa.

Adenoids↗
PubMed1985

Mechanoreceptive submodality channel interactions: psychophysical observations on differential activation of flutter and vibration.

Psychophysical studies on masking of sensations induced by sinusoidal mechanical stimuli were conducted in human subjects to characterize the interactions within and between the submodalities of flutter and vibration. Using a conditioning-test stimulus paradigm, we found that the threshold of a test stimulus was elevated (masking) when the test stimulus was paired with a twice-threshold conditioning stimulus that activated the same submodality. Detection theory analysis further indicated that the observed elevation in threshold resulted in part from a change in stimulus detectability (i.e.d'). In contrast, when the test stimulus and the twice-threshold conditioning stimulus activated different submodalities, no elevation in test stimulus threshold (no masking) was observed. Thus, for stimuli that activate either flutter or vibration, masking (and the inhibitory operations by which it is presumably mediated) is restricted to a given submodality and not distributed across submodalities. This finding suggests that these submodality channels function independently.

Humans↗
PubMed1985

Pupillary constriction evoked from the posterior medial lateral suprasylvian (PMLS) area in cats.

Pupillary constriction was evoked by systematic stimulation using a microelectrode in the upper medial bank of the middle suprasylvian sulcus in the parieto-occipital cortex of the cat. The pupillo-constrictor area corresponded to the rostral and middle parts of the posterior medial lateral suprasylvian (PMLS) area. This pupillo-constrictor area extended by 2-3 mm along the middle suprasylvian sulcus. It is suggested that this pupillo-constrictor area overlaps or lies in close proximity of a part of the region in PMLS area related to lens accommodation, in which unit activity temporally related to lens accommodation was recorded and from which lens accommodation was evoked by electric stimulation.

Accommodation, Ocular↗
PubMed1985

Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line.

Neoplastic intercalated duct cells that originated from a human submandibular salivary gland release transforming growth factor and human epidermal growth factor into serum-free medium. The transforming growth factor with the soft agar colony-forming activity when assayed in the presence of mouse epidermal growth factor on normal rat kidney clone 49F indicator cells, but without mitogenic action to quiescent 3T3 cells, does not compete with epidermal growth factor for receptor binding, is heat and acid resistant but trypsin and dithiothreitol sensitive, and therefore is of the transforming growth factor-beta class. The immunoreactive human epidermal growth factor is detected by radioimmunoassay on certain fractions obtained by the Bio-Gel P-60 chromatography of neoplastic epithelial duct cells originated from a human submandibular salivary gland-conditioned medium and is biologically very similar to mouse epidermal growth factor. Moreover, the presence of human epidermal growth factor in cultured neoplastic epithelial duct cells originated from a human submandibular salivary gland is demonstrated by the peroxidase:antiperoxidase method.

Adenocarcinoma↗