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T B Anderson

Publications and source records attributed to T B Anderson.

At least 19 recordsLinked to original sources
PubMed2001

Genetic and transcriptional analysis of absA, an antibiotic gene cluster-linked two-component system that regulates multiple antibiotics in Streptomyces coelicolor.

In Streptomyces coelicolor, the AbsA1-AbsA2 two-component system regulates the expression of multiple antibiotic gene clusters. Here, we show that the response regulator encoded by the absA2 gene is a negative regulator of these antibiotic gene clusters. A genetic analysis shows that the phosphorylated form of the AbsA2 response regulator (phospho-AbsA2), generated by the cognate AbsA1 sensor histidine kinase, is required for normal growth phase regulation of antibiotic synthesis. In the absence of phospho-AbsA2, antibiotics are produced earlier and more abundantly. Overexpression of AbsA1 also deregulates antibiotic synthesis, apparently shifting the AbsA1 protein from a kinase-active to a phospho-AbsA2 phosphatase-active form. The absA1 and absA2 genes, which are adjacent, are located in one of the antibiotic gene clusters that they regulate, the cluster for the calcium-dependent antibiotic (CDA). The absA genes themselves are growth phase regulated, with phospho-AbsA2 responsible for growth phase-related positive autoregulation. We discuss the possible role and mechanism of AbsA-mediated regulation of antibiotic synthesis in the S. coelicolor life cycle.

Anthraquinones↗
PubMed1997

The therapeutic role in later life: husbands, wives and couples.

The present study investigates the extent to which marital partners are different or similar in their ways of enacting the therapeutic, or supportive, role. Specifically, the article compares husbands and wives categorically as in non-dyadic studies and then as marital partners as in dyadic studies. In addition, this study, by using data from the Aging Couples Study, included only dual-earner couples so as to control for the effects of work life on marital relations. Results showed that studies of individual married men and women understate the differences between marital partners in that some wives "overbenefit" in the exchange of conjugal supports. However, husbands more often "overbenefit." Findings also indicated that the norm of reciprocity does not prevail regarding the extent of support, although it does for the types of support exchanged.

Aged↗
PubMed1993

Conjugal support: factor structure for older husbands and wives.

The purpose of this study was to investigate the factor structure of social support among older spouses. The sample consisted of 298 older marital dyads who participated in the Aging Couples Study. Confirmatory factor analysis techniques were used to examine conjugal support in a series of nested measurement models at the couple and individual levels. Two research questions were addressed: (a) the viability of conjugal support as a couple's construct, and (b) the dimensionality of social support within the marital dyad. Results showed that conjugal support was a husband/wife, rather than a couple, construct. Findings also showed that conjugal support was a multidimensional construct consisting of three factors: instrumental support, emotional support, and confiding. Moreover, husbands and wives perceived the dimensions of conjugal support differently.

Aged↗
PubMed1989

Older widows and married women: their intimates and confidants.

Interview data obtained from 132 women sixty-five and older reveals that the widows and married women have a comparable number of primary friends. Being over age seventy-four influences the size of the friendship network for widows but not married women. The primary friendships of widows and married women parallel each other in terms of endurance and stability. Primary ties with men are the exception rather than the norm, for both widows and married women. Widows do differ from married women in that the former rely on confidant friends to a greater extent. Ties between older women and their confidants are characterized by norms of reciprocity.

Aged↗
PubMed1965

Asian influenza in 1963 in two general practices in Cambridge, England.

A clinical, epidemiological and virological investigation was conducted on patients in two general practices in Cambridge, England, during an influenza epidemic between February and April 1963. The epidemiological pattern differed from that of the 1957-58 Asian influenza epidemic in that the overall incidence was considerably lower (3.2%) and that the highest attack rates were not in school children but in pre-school children (71.5 per 1000 persons).Virological investigation confirmed the diagnosis of Influenza A2 infection in 56 of 63 patients (89%). Isolations were made in 29 of 51 specimens tested. Serological studies revealed that the complement fixation test was more reliable than hemagglutination - inhibition or neutralization tests. Clinical features resembled those reported in previous epidemics, cough, headache and limb pains being prominent features.

Adolescent↗