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Biomedical subjects

T Asai

Publications and source records attributed to T Asai.

At least 577 records · Page 32Linked to original sources
PubMed1978

HLA antigens in Kawasaki disease.

Two hundred five patients with Kawasaki disease and 500 normal controls were HLA-typed, using a standard microcytotoxicity test of tissue typing. HLA-BW22 was more common in patients with Kawasaki disease than in normal controls (25.4% instead of 11.8%, corrected P less than .0005). Among subtypes of HLA-BW22 antigen, Kawasaki disease was associated with HLA-BW22J2, which was found specifically in Japanese and not in Caucasians. These facts may suggest that there is a gene controlling the susceptibility to Kawasaki disease and linked with a Japanese-specific HLA antigen.

Child↗
PubMed1977

Immunological and biological characteristics of a new TRF analogue, L-pyroglutamyl-L-histidyl-L-pipecolic acid amide.

The immunological and biological potencies of a new synthetic TRF analogue, L-pyroglutamyl-L-histidyl-L-pipecolic acid amide, were compared with those of TRF. In a radioimmunoassay system for TRF, parallel inhibition curves were obtained with TRF and the analogue, the immunological potency of the latter being approximately 50 per cent of the former. In vitro and in vivo TSH-releasing activities of the analogue were almost equal to those of TRF. As was observed with TRF, the in vitro TSH-releasing effect of the analogue was reduced in the presence of T4, and the analogue was inactivated by incubation with rat serum. The data suggest that the pyrrolidine ring of TRF can be replaced with piperidine ring without significant loss of the biological activity.

Animals↗
PubMed1977

A probable case of Leishmaniasis (Espundia) acquired in Japan.

A case of mucocutaneous leishmaniasis is described in a Japanese patient who had never been abroad, suggesting either contact with an infected person from Brazil or the presence in Japan of indigenous cutaneous leishmaniasis. This case illustrates the value of electron microscopic examination in such infections, since it provided the definitive diagnosis.

Adult↗