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Biomedical subjects

T Appelboom

Publications and source records attributed to T Appelboom.

At least 91 records · Page 5Linked to original sources
PubMed1985

Retinoblastoma presenting as a total hyphema.

Retinoblastoma, the most common intraocular malignancy of childhood, presents in many patterns, typically as the easily recognizable signs of leukokoria, glaucoma, strabismus, or vision loss. A small percentage manifest as other more common diagnoses. These more unusual signs can involve any portion of the eye segment, including the orbit and lids, the anterior segment, and the posterior segment, as well as produce systemic illness. This paper deals with the first reported case of retinoblastoma presenting as a spontaneous total hyphema. Accurate diagnosis of similar situations can only be made by means of a high index of suspicion of malignancy and the use of diagnostic tests such as ultrasound and computed axial tomographic scanning.

Diagnosis, Differential↗
PubMed1984

Leukocyte sensitization against synovial components in rheumatoid arthritis: blocking by pregnancy serum.

The leukocyte adherence inhibition (LAI) test in arthritis can serve as an in vitro model for investigating cellular cooperation between mononuclear cells sensitized by cytophilic IgG rheumatoid factor(s) present in rheumatoid arthritis (RA) serum, normal synovial components, and polymorphonuclear cells. Since inflammatory and immunologic responses are altered during pregnancy, we studied the effect of pregnancy serum on the LAI. The adherence of normal leukocytes once sensitized in RA serum is inhibited by a synovial extract, but when these leukocytes are exposed to pregnancy serum prior to sensitization with RA serum, the cells are unresponsive to subsequent stimulation by the synovial extract (p less than 0.01). This blocking effect on sensitization is only present in serum obtained after the first trimester of pregnancy and can be detected even at serum dilutions of 1:100. Leukocytes obtained directly from pregnant subjects, washed, and then incubated with RA serum failed to react. Since pregnancy serum has been shown to mask certain cell membrane receptors, it is possible that our results are due to the blocking of IgG rheumatoid factor binding to mononuclear cells. This finding could contribute to the subsidence during pregnancy of some disorders such as rheumatoid arthritis.

Arthritis, Rheumatoid↗
PubMed1983

Overlapping connective tissue diseases in children.

Of 18 children with different connective tissue diseases four were found to have overlaps. Two presented features of SLE and PSS or SLE and PM and 2 had features of SLE, PSS and JRA. In two of them antiribonucleoprotein antibodies were detected by radical immunodiffusion. But these antibodies were also detected in a few children suffering from a single connective tissue disease. On the other hand, the six children with anti-RNP were not characterized by a particular clinical picture or a better prognosis; when compared to adults, no significant difference could be observed except that the Raynaud phenomenon, sausage fingers and myositis seemed less frequent in childhood. It may be concluded that combinations of connective tissue disease can occur in children but anti-RNP does not appear as a good biological marker.

Adolescent↗
PubMed1981

Rubens and the question of antiquity of rheumatoid arthritis.

Analysis of the hands in paintings attributed to Peter Paul Rubens during the last 30 years of his life seems to show progressive rheumatoid arthritis. Not only does this suggest that rheumatoid arthritis was present at the time, 200 years before some modern authors are willing to date its appearance, but also that Rubens or a major and consistent collaborator suffered from the disease.

Art↗
PubMed1981

Effect of levamisole on leukocyte adherence inhibition.

The leukocyte adherence inhibition test can serve as an in vitro model to investigate the cellular cooperation between T cells, monocytes and polymorphonuclear cells (PMN) but also the mechanism of cell adherence. Therefore, the effect of levamisole on the production of PMN activating factors by mononuclear cells and on cell adherence was studied with leukocytes from polyarthritic patients. Levamisole at concentrations ranging from 10(-9) M to 10(-4) M did not seem to affect the production of activating factors. These results differentiate levamisole from anti-inflammatory drugs which are potent inhibitors. On the other hand, levamisole increased markedly the adherence of leucocytes, mainly mononuclear cells, obtained from polyarthritic patients, or normal cells preincubated in a polyarthritic serum. This could be related to a direct effect of levamisole on the leukocyte membrane.

Anti-Inflammatory Agents↗
PubMed1979

Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes.

This study reports the in vitro influence of morphine, dextromoramide, levomoramide, and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests. Morphine and dextromoramide inhibited the percentage of active T rosettes. This effect was completely reversed in the presence of naloxone, their specific antagonist. The specificity was further demonstrated by the absence of the effect of levomoramide, the inactive enantiomere, upon the rosette system. Methionine-enkephalin increased the percentage of active T rosettes. This effect was specifically inhibited by naloxone. These observations suggest that normal human blood T lymphocytes bear surface receptor-like structures for morphine, dextromoramide, and methionine-enkephalin. Such findings may provide a link between the central nervous system and the immune system.

Binding Sites↗
PubMed1978

Leucocyte adherence inhibition test in arthritis.

Peripheral leucocytes from healthy blood-donors were preincubated in polyarthritic serum or normal serum and their adherence to glass tubes in the presence of synovial extract of control extract was measured. Serum from patients with inflammatory polyarthritis significantly reduced the proportion of leucocytes which adhered in the presence of synovial extract, but not control extract. Serum from patients with polyarthritis with visceral manifestations, patients with degenerative or metabolic polyarthritis or rheumatic fever, and controls did not have this effect. The leucocyte sensitising activity was eluted in the IgG fraction of serum, and could be absorbed by both synovial extract and IgG. It is thus probably IgG rheumatoid factor. In vivo, armed leucocytes in polyarthritic patients may bind to synovial tissue initiating or perpetuating the articular inflammatory process.

Adult↗