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Biomedical subjects

S Zimmermann

Publications and source records attributed to S Zimmermann.

At least 127 records · Page 7Linked to original sources
PubMed1979

[Ulcer anamnesis and gastroduodenoscopic findings--a contribution to the symptomatology of gastroduodenal ulcers].

513 patients who were gastroduodenoscopically examined on account of suspicion of ulcer were aimedly inquired for 18 typical ulcer complaints. Compared with patients with normal gastroduodenoscopic findings patients peptic ulcers of erosions of the gastric mucous membrane had significantly more frequently symptoms of the gastrointestinal haemorrhage, patients with ulcus ventriculi had, moreover, inappetence and vomiting, patients with duodenal ulcer a late pain in the centre of the epigastrium and in the right epigastrium. But these symptoms did not allow a significant differentiation between the patients with ventricular ulcer and duodenal ulcer. Patients without pathological gastroduodenoscopic findings had significantly more frequently an incompatibility of food and connected with this sensation of fullness. A typical symptomatology of ulcer may, indeed, be present in the individual case, but according to the results of the study it is no sufficient proof for the actual existence of a peptic ulcer and is thus of little differential-diagnostic value.

Diagnosis, Differential↗
PubMed1977

[Fiber-optic endoscopy demonstration, incidence and clinical significance of intestinal lymphangiectasis].

The intestinal lymphangiectasia can be proved enteroscopically, laparoscopically as well as histologically after preceding aimed or unaimed biopsy. In 2,250 fibre-endoscopic examinations of the upper gastrointestinal tract we found 54 times endoscopically and 48 times also histologically a lymphangiectasia. Of these 54 patients 9 had an advanced carcinoma of the stomach. The evoking causes of the lymphangiectasia are discussed. When an intestinal lymphagniectasia is diagnosed it should always be sought for an evoking cause and last not least should be thought of a primary or secondary neoformation in the region of the epigastrium.

Biopsy↗
PubMed1977

[Benign monoclonal gammapathies].

Monoclonal immunoglobulins (= paraproteins) in zone electrophoretic separation on paper, cellulose acetate foil or agar are demonstrated as narrow base gradients, which refers to the homogeneity of the molecules of the immunoglobulins. In unselected population they are observed in 0.1 to 1.2%, in which cases they more frequently appear with growing age, in persons older than 70 years they were established in 3%. The cause in question is only in a small part a plasmocytoma or another lymphoreticular disease. In the majority of cases, particularly in the cases with insignificant concentration of M-gradients the appearance of monoclonal immunoglobulins is the only deviation from the normal in an examination, which led to the notion essential benign monoclonal gammapathy. A therapy of this benign gammapathy is not necessary. For the demarcation of an early form of a plasmocytoma long-term controls with measuring of the concentration of the monoclonal immunoglobulin shall be carried out, since a permanent increase of the paraproteinaemia is the most reliable sign of a malignant gammapathy. Clinical observation and experimental investigations on animals make probable that the causes for the appearance of a benign monoclonal gammapathy are to be traced back to a special antigen stimulation in genetic disposition.

Adult↗
PubMed1977

[Examination of cell-mediated immunity using the leukocyte migration inhibition test in agarose].

The 2-phase-leucocyte-migration-inhibition-test in agarose after Clausen is suitable for the proof of the cell-mediated immunity. Compared with the capillary technique of Soborg and Bendixen it has some methodical advantages. Between the migration inhibition against tuberculin and the result of the intracutaneous tuberculin testing a significant negative correlation was the result. The migration inhibition against a streptolysin-streptokinase-mixture was provable in 21 out of 22 patients with renal insufficiency in the same size as in clinically healthy persons.

Cell Migration Inhibition↗
PubMed1976

[Humoral immune reaction in chronic liver diseases].

In 60 patients with a morphologically ascertained chronic liver disease and 40 hepatologically examined patients with a healthy liver of a control group the quantitative determination of the immunoglobulin and the immunofluorescence-serological determination of antibodies against nuclei, smooth musculature and mitochondria were carried out. Only in one female patient with a chronic active hepatitis out of 51 patients with morphologically ascertained liver cirrhosis or chronic active hepatitis antibodies against nuclei and smooth musculature in a level of the titre of more than 1 : 40 and only in 2 female patients with a primary biliary cirrhosis antibodies against mitochondria could be proved in a level of the titre of more than 160. Titres of antibodies lying below were found in the group of patients with liver diseases and the control group in the same frequency, so that an autoimmune form of the cryptogenic cirrhosis could not be differentiated. The proof of antibodies against nuclei and smooth musculature of a high titre in connection with an isolated increase of the IgG is of special diagnostic importance for the autoimmune form of the chronic active hepatitis; the same is the case in the proof of antibodies against mitochondria of a high titre in connection with an isolated increase of IgM.

Adult↗
PubMed1975

[Determination of immunoglobulins in acute and chronic coronary disease].

51 patients with chronic ischaemic heart disease showed on the average increases of IgA and IgG, but a significance concerning a control group could not be calculated. Compared with the normal group 41 patients with acute myocardial infarction did not reveal a significant increase of all three immunoglobulins. The observations of the course after myocardial infarction had the following result: During the first five days IgG in the majority decreased to 90% of the initial value and in the second to third week it increased to a maximum of on the average 150% of the initial value. 8 patients did not show a change of the IgG-level after infarction, in 4 patients the IgG-level still continuously decreased also in the second week. In 23 patients IgA increased to the double in the second and third week, in 18 patients it remained uninfluenced. The increase of IgM was to be established in 15 patients in whom at the same time in increase of IgA appeared. A relation between the values of IgG and the clinical parameters of the myocardial infarction could not be proved.

Acute Disease↗
PubMed1975

[Problems of hepatitis in dialysis patients, technical personnel and their relatives].

In a centre for dialytic treatment of the district Karl-Marx-Stadt during 16 months patients and staff underwent a continuous clinico-epidemiological observation. By means of determinations of serum enzymes and Au-antigen-investigation regularly carried out in these cases the special risk of hepatitis could be confirmed. Hygienic-antiepidemic and organization measures are discussed and recommendations are given concerning the prophylactically more aimed course. Further investigations are necessary in as far as certain basic diseases (i.g., renal insufficiency) have an influence on the Au-antigen-persistence by impairment of the immune system and which epidemiological effects may result from this.

Female↗
PubMed1975

[Report on results of an intensive care unit at a district hospital].

The experiences of an internal intensive observation and therapy unit in a district hospital are reported. During 4 years 2,803 patients were admitted. 65% showed life-threatening disturbances of the heart and of the circulation. Arrangement of the rooms, personal staff as well as special diagnostic and therapeutic methods are described.

Acute Disease↗