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Biomedical subjects

S Yang

Publications and source records attributed to S Yang.

At least 649 records · Page 36Linked to original sources
PubMed1988

[Papilloma of forestomach induced by Fusarium T-2 toxin in mice].

T-2 toxin is one of the important representatives of trichothecin metabolites of Fusarium species. Various proliferative changes in epithelia of forestomach including papillomas were induced in mice after prolonged feeding of T-2 toxin by intubation at 0.1 mg/kg, 3 times a week for 25 weeks. The incidences of hyperkeratosis, papillary hyperplasia, moderate dysplasia and papilloma were 82.9%, 28.6%, 42.9% and 14.3% respectively. The earliest papilloma in forestomach of mice occurred as early as 6th week of the experiment. While in forestomach of mice in the control group, only 4.20% hyperkeratosis and 4.2% simple hyperplasia were found, no papillary hyperplasia or papilloma occurred. The above results indicate that T-2 toxin has a selective tumorigenic effect on the forestomach which is actually the extension of the esophagus in mice. These findings may give important hint to the study of human esophageal carcinogenesis.

Animals↗
PubMed1986

Differential effects of dopamine agonists on acoustically and electrically elicited startle responses: comparison to effects of strychnine.

This study sought to determine where drugs that are known to alter sensorimotor reactivity measured with the acoustic startle reflex ultimately act within the acoustic startle pathway. To do this, startle was elicited either acoustically or electrically within various nuclei believed to comprise the acoustic startle pathway. Direct infusion of serotonin into the subarachnoid space of the lumbar spinal cord increased acoustic startle and startle elicited electrically through the ventral cochlear nucleus (VCN) to a comparable degree. Subconvulsant doses of strychnine increased startle elicited acoustically or electrically through either the VCN or the nucleus reticularis pontis caudalis (RPC), pointing to a spinal locus of action of strychnine after systemic administration. In marked contrast, the dopamine agonists d-amphetamine and apomorphine consistently increased acoustic startle but actually depressed startle elicited electrically through the VCN or the RPC. These later results suggest that dopamine agonists increase sensorimotor reactivity measured with acoustic startle by acting on sensory rather than motor parts of the reflex arc.

Acoustic Stimulation↗