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Biomedical subjects

S Yang

Publications and source records attributed to S Yang.

At least 631 records · Page 35Linked to original sources
PubMed1990

Effects of multiple dose infections with Ascaris suum on blood gastrointestinal hormone levels in pigs.

Ten consecutive daily doses of infective Ascaris suum eggs were administered to pigs in two experiments and the levels of gastrointestinal hormones in their blood were measured. The piglets in each experiment were divided into low-dose (LDI) and high-dose (HDI) infections and control groups. Infected pigs had lower feed consumption, lower weight gains, and lower feed efficiency than control pigs. Serum gastrin levels in infected pigs were significantly lower than the controls from Days 7 to 17 post first inoculation (PFI), and so were their serum glucagon levels from Days 12 to 24 PFI. Serum insulin levels in infected animals were sometimes lower than those in controls. These differences were usually more intense in the LDI pigs than in HDI pigs. The plasma cholecystokinin (CCK) levels in the LDI group were significantly higher than those in controls from Day 10 PFI to the end of the experiment, while the CCK levels in the HDI group did not differ significantly from the controls. Increased plasma CCK levels could be a satiety factor in A. suum infection since the time of occurrence of high levels of CCK matched the period of reduced feed consumption.

Animals↗
PubMed1990

Serum levels of gastrin, insulin and glucagon as possible factors of anorexia in pigs infected once with Ascaris suum.

In order to determine possible mediators for development of anorexia in pigs infected with Ascaris suum, serum levels of gastrin, insulin and glucagon were measured. After a single high oral dose of 100,000-200,000 embryonated eggs the serum levels of gastrin and insulin in the infected pigs did not significantly differ from those in controls. Serum glucagon levels in the infected groups, however, were lower than those in controls and the difference was more evident 24 days postinoculation and later.

Animals↗
PubMed1990

Tumor necrosis factor-like cytotoxicity and anorexia in Ascaris suum infected pigs.

Tumor Necrosis Factor-Like Cytotoxicity (TNF-LC) was examined in sera from 12 pigs experimentally infected with Ascaris suum. The difference of TNF-LC levels between eight infected and four uninfected controls was not significant. When an endotoxin challenge was intravenously administered 1 month after the first dose of A. suum, the levels of TNF-LC in the sera of infected pigs were one-third that of the controls 125 min post-challenge (PC). In a more detailed study on four infected and two uninfected control pigs, TNF-LC was monitored every 10-15 min until 125 min after endotoxin challenge. The TNF-LC levels in these pigs increased at 40 min PC, reached maximum in another 10-25 min and then decreased. This pattern was seen in all except one infected pig. The infected pigs showed milder shock symptoms and their serum TNF-LC levels returned to pre-challenge levels 30 min earlier than controls.

Animals↗
PubMed1990

[A simplified polygraphic method for studying sleep in the rat].

Experiments were performed on 10 healthy Wistar rats with chronically implanted electrodes for the recording of electrocorticogram (ECoG), electro-oculogram (EOG), and electromyography (EMG). All the rats were prepared for the implantation of recording electrodes under 5% Ketamine (100 mg/kg i.p.) anesthesia. Four to six days after operation, the rat was put in an apparatus which was designed specifically sensitive to detect the movement of the animal without electrode on the body so that electroactogram (EAG) could be recorded readily. One group of experiment animal (n = 5), recorded ECoG, EAG, EOG and EMG simultaneously, was compared to another group (n = 5), recorded ECoG and EAG simultaneously. The results of experiments indicate that the ECoG, recorded from the the mesial frontal and occipital areas, have certain characteristics during different sleep phases, and the characteristics for classifying sleep phases by the two kinds of somnopolygram are similar. Therefore, simultaneous recording of the ECoG and EAG can be used to discriminate the sleep phases in the rat. In this way, the somnopolygraphic recording method for studying sleep in the rat would be simplified.

Animals↗
PubMed1990

[Identification methods of mineral drugs].

This paper recommends thirteen methods for identifying mineral drugs on the basis of their physical characteristics and chemical properties. An identification table of popular mineral drugs is given.

Materia Medica↗
PubMed1990

[Cardiac disease and stroke].

1074 patients with valvular heart diseases (VHD), non-valvular atrial fibrillation (NVAF) and acute myocardial infarction (AMI) in the last ten years were surveyed. 12.1% of patients (130/1074) were associated with stroke. The incidence in VHD was 27.2% (73/268), in NVAF 19.1% (42/220) and in AMI 2.3% (13/569), the former two are significantly higher than the last one (P less than 0.005).

Adolescent↗
PubMed1990

[Sedative-hypnotic effect of caulis Polygoni multiflori decoction].

The sedative-hypnotic effect of Caulis Polygoni multiflori decoction (CPMD) was studied by the rolling cylinder method in mice and by the somnopolygraphic recording method in rats. The result from the rolling method in mice showed that CPMD (9g/kg) did have synergic action with the subthreshold hypnotic dose of sodium pentobarbital (20mg/kg). The result from the somnopolygraphic recording experiment showed that the immediate hypnotic effect of an effective dose of CPMD (20g/kg) was basically similar to that of diazepam (5mg/kg) used under the same experimental condition, chiefly an increase in the duration of slow wave sleep phase (SWS) and a decrease in the duration of paradoxical sleep phase (PS). By the end of a three-day session in dose of twice a day the hypnotic effect appeared more prominent and the reduction of SWS latency became significant.

Animals↗
PubMed1990

[Influence of Rhizoma pinelliae on the occurrence of micronucleus in bone marrow polychromatic erythrocytes (PCE) in mice and frequencies of SCE in cultured human lymphocytes].

Contradictory effects of Rhizoma Pinelliae have been reported in pregnant mice, rats and rabbits, because the decoction of Rhizoma Pinelliae has obvious embryotoxicity. This paper was obtain an experimental analysis of the frequencies of micronucleus of bone marrow polychromatic erythrocytes (PCE) in mice and sister chromatid exchange (SCE) in cultural lymphocytes of human. The results showed that the decoction of Rhizoma Pinelliae neither induces the occurrencies of micronucleus nor SCE frequencies. Therefore, it may be concluded that the decoction does not have toxicogenetical effects.

Animals↗
PubMed1989

Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex.

Previous work has shown that stimulation of alpha 2-adrenergic receptors depresses the startle responses in rats. The present study suggests that this depressant effect involves supraspinal rather than spinal alpha 2-adrenergic receptors because intraventricular but not intrathecal infusion of the hydrophilic alpha 2-adrenergic agonist ST-91 depressed the acoustic startle reflex. To determine the point in the acoustic startle pathway where alpha 2-adrenergic receptor activation might ultimately alter neural transmission, startle responses were elicited electrically from different points along the acoustic startle pathway after systemic administration of clonidine. Clonidine depressed acoustically-elicited startle and startle elicited by electrical stimulation of the ventral cochlear nucleus to a comparable magnitude and over a similar time course. It also partially depressed startle elicited by electrical stimulation of the nucleus reticularis pontis caudalis (RPC). Taken together, these data suggest that alpha 2-adrenergic stimulation depresses startle by acting on supraspinal receptors, but that this effect is ultimately expressed, at least in part, by actions at both spinal and brainstem levels of the acoustic startle response pathway. The results are compared to other drugs known to affect the startle reflex.

Acoustic Stimulation↗
PubMed1989

[Investigation of the mechanism of hoarseness after thyroidectomy].

Electromyography of the intrinsic laryngeal muscles and laryngeal function measurements were performed on 34 patients with hoarseness after thyroidectomy. It is believed that mild laryngeal nerve paralysis might not give rise to disturbances in vocal cord movement. Causes of hoarseness after thyroidectomy could be mild recurrent superior laryngeal or combined nerve paralysis. During recovery, the vocal cord moved from paramedian position to middle position. Normal vocal cord movements did not mean complete recovery from paralysis, since electromyogram still showed abnormal potentials. It is suggested that vocal cord paralysis be divided into three types: severe, moderate and mild.

Adenoma↗