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Biomedical subjects

S Yanagi

Publications and source records attributed to S Yanagi.

At least 109 records · Page 6Linked to original sources
PubMed1984

[A case of XYY syndrome with male infertility and retentio testis].

A case of the XYY syndrome is reported. A 29-year-old man visited our hospital because of infertility and right undescended testicle. He was tall (181 cm) and his intelligence level was below average but his character was not violent. His right testis was touched in his right inguinal region and it was atrophic. Analysis of the semen showed no sperm. The biopsied specimen of his left descended testis as well as right undescended testicle showed spermatogenic arrest. Consequently we speculated that the spermatogenesis was injured by the surplus Y chromosome. On endocrinologic examination, plasma LH and FSH were high and testosterone revealed to be low. These data were slightly abnormal, but similar to those of most previous investigators.

Adult↗
PubMed1984

Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis.

A probably promoter-specific decrease of L-type pyruvate kinase (L-PK) in Wistar rat liver is described. The possibility of utilizing the decrease in L-PK activity for screening of hepatic promoters is discussed. A significantly decreased level of activity of L-PK was observed during continuous feedings of the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene [(3'-MeDAB) CAS: 55-80-1], which initiates and promotes hepatocarcinogenesis, and of the known hepatic promoters phenobarbital [(PB) CAS: 50-06-6] and dichlorodiphenyltrichloroethane (CAS: 50-29-3) for at least 4 weeks. In contrast, if it occurred, the decrease in L-PK activity by the nonpromoting agents amobarbital (CAS: 57-43-2) and diphenylhydantoin. (CAS: 57-41-0) was temporary and almost overcome by the 4th week. The depression of L-PK activity caused by PB was reversible, was inversely correlated with PB concentration in the diet, and seemed to be organ-specific. Although hepatic promoters lowered L-PK activity in this study, data are so limited that a much more extensive study is necessary before a general conclusion can be drawn. In contrast to L-PK activity, the activity of K-type pyruvate kinase (K-PK) was induced by injections of the carcinogen diethylnitrosamine (CAS: 55-18-5) or the hepatotoxin CCl4 (CAS: 56-23-5) or by the feeding of 3'-MeDAB. However, feeding of PB or 2-methyl-4-dimethylaminoazobenzene (CAS: 54-88-6), which initiates but does not promote hepatocarcinogenesis, did not increase K-PK activity.

Animals↗
PubMed1984

Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids.

The histologic classification of mouse liver tumors, i.e., hepatic nodules type 1 and type 2 and hepatocellular carcinomas, was evaluated by a comparison of several biologic and biochemical markers that have been shown to be useful for the grading of tumor malignancy. The liver tumors were induced by N,N'-2,7-fluorenylenebisacetamide (CAS: 304-28-9; N,N'-fluoren-2,7-ylenebisacetamide) administration to male CD-1 mice. The ability to induce L-type pyruvate kinase activity in response to a high-carbohydrate diet disappeared in almost all the liver tumors. However, fairly good correlations were observed between the histologic classification and the relative weights of liver and intraperitoneal fat pads, between the histologic classification and the level of serum total cholesterol, and between the histologic classification and the K-type pyruvate kinase activity. The results suggest that the present histologic classification reflects the degree of tumor malignancy, and therefore, it would be useful for the classification of mouse liver tumors.

Animals↗
PubMed1983

Coexistence of hyperplasia of renomedullary interstitial cells and juxtaglomerular cells after acute occlusion of renal artery.

A left renal artery aneurysm was found in a 45-year-old normotensive man. In an attempt to evade the possible occurrence of aneurysmal rupture, aneurysmectomy in addition to left renal biopsy (first surgery) was performed. This vascular operation led to a virtually complete renal artery stenosis concomitant with the development of hypertension. The renin-angiotensin-aldosterone system and levels of plasma prostaglandins were also increased following this failed surgery. Reconstruction of the affected renal artery was technically so difficult that left nephrectomy was carried out (second surgery). Renal specimens obtained at the first surgery revealed no histological abnormalities. Discriminating histological findings of the kidney obtained at the second surgery were remarkable; hyperplasia of the juxtaglomerular cells producing renin and hyperplasia of the renomedullary interstitial cells which had pecularities similar to cells known to secrete renal prostaglandins. High levels of the renin-angiotensin-aldosterone system and plasma prostaglandins after the first surgery were reduced following the second surgery. It is suggested that acute constriction of the renal artery led to a hyperplastic change of the juxtaglomerular cells and the renomedullary interstitial cells and stimulated an inappropriate release of renin and renal prostaglandins.

Acute Disease↗
PubMed1982

Successful treatment of renovascular hypertension with a percutaneous transluminal angioplasty.

We report a case of typical renovascular hypertension due to right renal artery stenosis treated with percutaneous transluminal angioplasty. The followup arteriogram demonstrated merely a partial dilatation of the stenotic segment but hypertension was remarkably improved. A right-to-left ratio of plasma renin activity in the renal venous effluent decreased from 2.67:1 to 1.10:1 following treatment. Affected renal function in the previously stenotic side was ameliorated. The procedure was well tolerated by the patient and blood pressure remained normotensive during the 5 months after angioplasty.

Aged↗
PubMed1982

Novel and sensitive activity stains on polyacrylamide gel of serine and threonine dehydratase and ornithine aminotransferase.

A sensitive activity stain for serine and threonine dehydratase is described. After electrophoresis on thin-layer polyacrylamide gel, a reaction mixture containing L-serine or L-threonine as a substrate, NADH, lactate dehydrogenase and agar was solidified on the gel. The oxidation of NADH was recorded by contact printing on photographic paper with UV light. A novel activity stain for ornithine aminotransferase in the gel is also described. A reaction mixture containing substrates, o-aminobenzaldehyde and agar was solidified on the gel. A yellow color developed in a reaction between pyrroline-5-carboxylate and o-aminobenzaldehyde. The photograph was taken by contact printing. Both of the methods are highly sensitive and can detect less than 0.01 unit (mumol product/min at 37 degrees C) of each enzyme.

Animals↗
PubMed1981

Induction by phenobarbital of ornithine decarboxylase activity in rat liver after initiation with diethylnitrosamine.

Dietary administration of 0.1% phenobarbital (PB) for 1-2 weeks increased ornithine decarboxylase (ODC) activity slightly but to a significant extent (P less than 0.05) in livers of rats into which diethylnitrosamine (DEN) (200 mg/kg body wt) had been injected intraperitoneally 2 weeks before phenobarbital feeding. The increase was observed only under the controlled feeding schedule which avoided the effect of food intake.

Animals↗