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Biomedical subjects

S Yamane

Publications and source records attributed to S Yamane.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Clinical evaluation of effectiveness of cefmetazole in bone and joint infections in the orthopedic field].

1. Cefmetazole (CMZ) was administered to a total number of 12 patients, 10 having acute or chronic osteomyelitis and 2 pyarthrosis in the orthopedic field. The efficacy rate was 91.7%. 2. Patients received an intravenous instillation of 1 to 2 g CMZ daily for an average period of 29.8 days. 3. Causative organisms were identified in 8 of the cases examined. In 7 cases S. aureus was isolated. CMZ showed an extremely strong antibacterial activity against S. aureus in a disk test in support of its excellent clinical results. 4. No abnormality was found with respect to subjective and objective symptoms and in laboratory tests. 5. The above results and migration of CMZ into the bone tissue at a high concentration suggest that CMZ is an effective and safe drug for bone and joint infection in the orthopedic field.

Adolescent↗
PubMed1979

Efficacy of acycloguanosine against herpetic ulcers in rabbit cornea.

The effect of a new antiherpetic compound of very low toxicity called acycloguanosine (Wellcome 248U) on herpetic ulcers in rabbit cornea was studied by the Corneal Epithelial Lesion Therapeutic Assay (CELTA). The therapeutic effect of 3% acycloguanosine ointment on dendritic ulcers was equal to that of 0.5% 5-iodo-2'-deoxyuridine (IDU) ointment. No toxic symptoms could be detected by slit-lamp on 4 days' treatment with this concentration of acycloguanosine. Because of its selective action on virus only, its extremely low toxicity in animals, and its availability for systemic administration, acycloguanosine seems to be an ideal antiviral compound for use in the treatment not only of herpetic keratitis but also of other herpetic diseases in man.

Animals↗
PubMed1977

Effects of ions and drugs on the negative afterpotential in the longitudinal muscle of pregnant rat myometrium.

Effect of Na, Ca anions and drugs (isoprenaline, TEA, procaine) on the negative afterpotential in the longitudinal muscle of pregnant rat myometrium were investigated using the double sucrose gap method. The negative afterpotential having a peak amplitude of about 15 mV decayed initially rapidly then slowly, the total duration being about 1 sec. Raising the external Ca concentration up to 10 mM or reducing Na to 54 mM increased the amplitude of the negative afterpotential. Replacement of Cl with Br enhanced the negative afterpotential and and replacement with benzene sulphonate or isethionate depressed it. The application of 10 mM TEA increased, while 10 mM procaine reduced the amplitude of both spike and negative afterpotential. 10(-10)-107(-8)g/ml isoprenaline depressed the negative afterpotential dosedependently, while leaving the spike potential nearly unaffected. It was concluded that the negative afterpotential was composed of a least two ionic mechanisms, one of Cl origin, the other of Ca origin.

Animals↗
PubMed1975

Effects of adapting lights on the time course of the receptor potential of the anuran retinal rod.

1. The intracellular receptor potential of the retinal rod cell was recorded in the unperfused, isolated retina of Rana catesbiana and in the perfused, isolated retina of Bufo marinus. Qualitatively, the responses from the two preparations were similar. 2. The rate at which the receptor potential returned to the dark level at the termination of a pulse of light (Voff) was measured at a fixed potential chosen to be about 0-6 of the way from the dark level to the peak of the response. 3. When the light intensity was such that less than about 10-minus 5 of the photopigment was bleached per second, Voff increased as the duration of the pulse was increased, reaching a maximum in 50-100 s. 4. When a brief test flash was presented at various intervals after an adapting pulse lasting about 50 s, Voff for the test flash was greater than the value in the dark adapted state for times up to about 80 s after the adapting pulse. 5. It has been hypothesized that in the vertebrate rod light causes release from the disk sacs of particles which block conducting channels in the surface membrane (Yoshikami & Hagins, 1971, 1973). A modification is proposed in which the blocking particles are converted to an inactive state can be increased by light adaptation. 6. This modified hypothesis will account qualitatively for the further observations that (a) during the response to illumination lasting several seconds the membrane potential recovers part of the way to the dark level and (b) if a second light pulse is superimposed on this background illumination then after the superimposed pulse the depolarization is increased.

Adaptation, Ocular↗