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Biomedical subjects

S Yalcin

Publications and source records attributed to S Yalcin.

At least 19 recordsLinked to original sources
PubMed2005

Investigation of hearing loss in patients with acute brucellosis by standard and high-frequency audiometry.

This study aimed to determine the effect of acute brucellosis on the auditory system. Forty-two patients with acute brucellosis were evaluated clinically, and with serological and audiological tests, before and after treatment. Hearing threshold averages were calculated at 11 different frequencies (250-8000 Hz) of the auditory airway, and statistical analysis was performed. The average hearing thresholds were > 20 dB, with standard audiometry at 6000-8000 Hz, and < 20 dB at all other frequencies. After treatment, the average auditory threshold decreased to < 20 dB at 6000-8000 Hz (p < 0.0001). Pure-tone hearing thresholds were improved at all frequencies after treatment, with statistically significant differences at all frequencies except 12,000, 14,000 and 16 000 Hz (p < 0.05). There was no permanent hearing loss caused by acute brucellosis, and hearing thresholds were restored after treatment. It was concluded that acute brucellosis affects the auditory system, especially at high frequencies, and that patients with all forms of brucellosis should be evaluated for hearing loss.

Adolescent↗
PubMed2005

Are some cases of spina bifida combined with cerebral palsy? A study of 28 cases.

AIM: This study is a description of a group of children with spina bifida who present with neurological impairments resembling cerebral palsy. Spina bifida is a complex congenital spinal anomaly causing paraparesis. Some children with spina bifida have neurological impairments, which fit into the definition of cerebral palsy. Extensive spasticity discordant with the level of the spina bifida lesion, upper extremity dysfunction and cognitive impairment are suggestive of concomitant cerebral palsy in these cases. The probable etiology for this problem may be neglected hydrocephalus, meningitis or other brain lesions common in spina bifida. METHODS: In this study we have reviewed our cohort of 365 patients and found 28 cases with the above-mentioned findings. Main evaluation parameters used were the Ashworth scale for spasticity, Green and Banks modified classification for hand function, cognitive function, mental status, ambulation and lesion level. RESULTS: Twenty-eight out of 365 children with spina bifida had neurological impairments resembling cerebral palsy. Their mean age was 59.9+/-41.3 (range, 16.8-31.2) months. Seventy percent of the patients were nonambulatory and therapeutic ambulation only was present in 30% of patients. Seventy percent of the children had spasticity of Ashworth grade 2 or higher. Upper extremity dysfunction, and cognitive impairment were also observed in 80% of the patients involved in this study. The spinal lesion was 60% thoracal and 20% upper lumbar, and none of the cases had signs of spinal tethering. CONCLUSIONS: We believe that this group of children with spina bifida may be regarded as having concomitant cerebral palsy. This fact implies that the management of this group of patients having mixed findings must be changed accordingly.

Cerebral Palsy↗
PubMed2004

Synchronous squamous cell carcinoma of the stomach, the lung and the skin.

BACKGROUND: The incidence of multiple primary cancers is reported to be 0.3-4.3%. CASE REPORT: A 70-year-old man was admitted to the hospital because of fatigue, weight loss, epigastric pain with melena. A biopsy taken from a tumoral lesion in the gastric corpus revealed squamous cell carcinoma. A nodular lesion was also detected on the nasal columella and biopsy from this lesion also showed squamous cell carcinoma. Computed tomography performed as a part of metastatic work-up revealed a lesion in the left pulmonary lower lobe. Bronchoscopic biopsy from this lesion also demonstrated squamous cell carcinoma. RESULTS: We report a case with synchronous squamous cell carcinoma of the lung, skin and stomach and discuss the multiple synchronous occurrence of carcinoma with the same histopathology in different sites with a review of the literature.

Aged↗
PubMed2001

Bacteriological and PCR analysis of clinical material aspirated from otitis media with effusions.

Otitis media with effusions (OME) can lead to significant hearing loss in childhood. Although previous studies have shown that bacterial DNA is present in a significant percentage of effusions sterile by culture, whether the DNA represents viable organisms or 'fossilized remains' is unknown. The aim of the present study was the determination of Streptococcus pneumonia, Moraxella catarrhalis and Haemophilus influenza in the clinical materials from OME. For this purpose, effusion samples aspirated from the mid-ear were analyzed bacteriologically. Samples were also tested with polymerase chain reaction (PCR) assay. A total of 37 samples obtained from 20 patients aging between 4 and 14 were analyzed. In 17 patients, both ears demonstrated effusions, whereas in three patients, only one ear had effusions. In aerobic bacterial culture assays, nine samples (24.3%) showed bacterial growth. None of the samples were positive for anaerobic culture experiments. PCR analysis of the samples showed that 35 samples (94.5%) contained bacterial DNA. In 19 samples, only one bacterial species and in 16 samples more than one bacterial species were detected. The results of this study demonstrate that effusion fluid from otitis media cases contain a battery of bacterial species and these bacteria might play roles in the pathogens of OME. Our results indicate the PCR technique is more specific and sensitive in detection of bacteria in middle-ear effusion of OME, compared with conventional methods.

Adolescent↗
PubMed2000

Primary low grade B-cell lymphoma of the dura in an immunocompetent patient.

Primary central nervous system lymphomas (PCNSL) represent only 1% of all non-Hodgkin's lymphomas (NHLs). A 66 year-old woman was hospitalized due to multiple episodes of syncope and seizures which occurred the week before admission to the hospital. A computerized tomography (CT) scan of the brain showed a right parietal lesion suggesting a subdural effusion. The patient was operated and a dural lesion extending to the epidural space and cerebral cortex was excised. Histologic findings suggested diagnosis of a low-grade lymphoma of the mucosa associated lymphoid tissue (MALT) type. The patient was treated with radiation therapy and has now completely recovered 12 months after surgery.

Aged↗
PubMed1999

Zinc exposure in Chinese foundry workers.

BACKGROUND: Inhalational exposure to zinc oxide fumes is associated with metal fume fever, a self-limited but very uncomfortable condition closely resembling influenza. Very little is known regarding the toxicokinetics of inhaled zinc, making the interpretation of zinc measurements in serum and urine problematic. METHODS: Twenty workers in a zinc foundry in Baiyin, Peoples' Republic of China, were investigated with serial examinations by a physician, chest radiographs, and spirometry. Exposure assessment consisted of the measurement of zinc in serum, urine, and personal air samples. RESULTS: No cases of metal fume fever were observed during the study period despite exposures to as high as 36.3 mg/m3 over less than 4 hr. In addition, no radiographic or functional changes were noted. Serum zinc levels of all workers were within the reference range and did not correlate with external exposure measurements. However, elevations were noted in urinary zinc levels, which showed a significant association (Spearman's correlation coefficient = 0.47, P = 0.04) between exposure to zinc and urine zinc. CONCLUSIONS: These results provide exposure measurements for zinc at which workers demonstrate tolerance to the development of metal fume fever. Furthermore, they suggest that urine may be the preferred biological medium for the assessment of zinc exposure.

Adult↗
PubMed1997

Bone characteristics and body weight of broilers in different husbandry systems.

1. An experiment was conducted to determine the effect of husbandry systems on bone characteristics and body weight. Broilers were reared in 5 different husbandry systems: wire mesh (WM) floored cages from 0 to 7 weeks; WM floored cages from 0 to 3 weeks and then transferred to floor pens; plastic mesh (PM) floored cages from 0 to 7 weeks; PM floored cages from 0 to 3 weeks and then transferred to floor pens; floor pens from 0 to 7 weeks. 2. Body weight at 3 weeks of age was affected by the husbandry systems, being greatest for the birds reared in floor pens. At 7 weeks of age, male broilers reared in PM floored cages had the lowest body weight and body weight gain from 4 to 7 weeks. 3. Humerus weight and ash content were affected by cage rearing whereas tibia weight and ash were not. Birds reared in PM cages had shorter tibia and humeri than birds reared in floor pens.

Aging↗
PubMed1997

Auditory brain stem evoked potentials in patients with leprosy.

Nineteen, randomly selected male patients with lepromatous leprosy were evaluated electrophysiologically. All of these patients had long-standing disease and were treated with dapsone alone. There were statistically significant differences between the values obtained in this group of leprosy patients compared to 20 age-matched controls in auditory brain stem evoked potentials (ABEP). The findings are consistent with a pathologic process located mainly between the cochlear nucleus and the lateral lemniscus in the auditory brain stem pathways. It should be emphasized that our patients had long-standing disease which was treated with dapsone. ABEP could very well be different in leprosy patients diagnosed early and treated for relatively short periods with multidrug therapy. Brain stem evoked response audiometry may be useful for evaluating the possibility of brain stem involvement in leprosy.

Adult↗
PubMed1995

Effect of selection for high or low incidence of tibial dyschondroplasia for seven generations on live performance.

An experiment was conducted to determine the effect of divergent selection for tibial dyschondroplasia (TD) on live performance of broilers. Broilers used in the experiment were produced from the parental lines selected for high (H) and low (L) incidence of TD and a randombred control (C) line. Diallel crosses were made between H and L lines. The offspring produced were HH, HL, LH, LL, and CC, where the first letter refers to sire line and the second letter refers to dam line. Body weights, average daily body weight gains, and exponential growth rates were determined at weekly intervals. The incidence of TD was recorded at 4 and 7 wk of age. There was no difference among body weights of lines up to 5 wk of age. Sire lines influenced body weights of birds from 5 to 7 wk of age. A significant interaction between sire and dam lines for body weight was the result of decreased body weights of birds in the HH line from 5 to 6 wk of age. There was a similar interaction for body weight gain, which resulted in a slower growth rate of birds in the HH line from 3 to 5 wk of age. Tibial dyschondroplasia incidence was 84.1 and 92.0% in the HH line, 5.6 and 5.4% in the LL line, and 7.0 and 13.2% in the CC line at 4 and 7 wk of age, respectively. It was suggested that genetic predisposition for TD was independent of body weight.

Animals↗
PubMed1994

Human herpesvirus 6 and human herpesvirus 7 infections in renal transplant recipients and healthy adults in Turkey.

We explored the prevalence of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) infections in 16 renal transplant recipients and 16 healthy controls by virus isolation, serology, polymerase chain reaction (PCR) followed by dot blot hybridization. HHV-6 variant A was isolated from one renal transplant recipient. Seven patients (44%) and six controls (38%) had HHV-6 variant B DNA in their peripheral blood mononuclear cells. The prevalence of HHV-7 DNA was found to be the same in patients and controls (19%).

Adult↗
PubMed1994

Prevalence of human herpesvirus 6 variants A and B in patients with chronic fatigue syndrome.

Peripheral blood mononuclear cells collected from 13 patients with chronic fatigue syndrome and 13 healthy controls were analyzed for the presence of human herpesvirus 6 (HHV-6) DNA by variant-specific polymerase chain reaction and dot blot hybridization. HHV-6 DNA was detected in 7 of 13 (53%) patients, and of those 7 patients, 4 were positive for HHV-6 variant A DNA and 3 were for variant B. No HHV-6 DNA was detected in the controls. Serum antibody titers to the late antigen and antibody prevalence to the early antigen of HHV-6 were significantly higher in the patient group. These results suggest active replication of HHV-6 in patients with chronic fatigue syndrome.

Antibodies, Viral↗
PubMed1994

Supernumerary molars and paramolars.

Thorough X-ray examination is a valuable adjunct in the clinical assessment of supernumerary teeth. Three cases of supernumerary teeth comprising paramolars and molars are presented with radiographic documentation. All the patients received surgical treatment after full clinical and radiographic evaluation.

Adolescent↗
PubMed1993

Ewing's tumor of the mandible.

A primary Ewing's tumor in the mandible is reported, and the diagnostic imaging features of this lesion are discussed. Modalities used included panoramic and plain films, computed tomography, and 99mTc-MDP scintigraphy.

Adolescent↗