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Biomedical subjects

S Wilkinson

Publications and source records attributed to S Wilkinson.

162 records · Page 9Linked to original sources
PubMedDate not supplied

Peripheral antinociceptive effects of N-methyl morphine.

Morphine and N-methyl morphine were compared in two antinociceptive tests in mice, the hotplate and acetic acid-induced writhing. Whereas morphine was active in both models, N-methyl morphine was only active in the writhing model. In this model, the antinociceptive effects of N-methyl morphine were antagonized by both naloxone and N-methyl nalorphine. In separate experiments the two quaternary analogues were both [14C]-labelled and shown not to penetrate the blood brain barrier. These results indicate a peripheral site of action for the opioid antinociceptive effects of N-methyl morphine in the writhing model.

Analgesia↗
PubMedDate not supplied

Use of a control serum containing a low level of HBsAg for monitoring proficiency in screening for HBsAg.

Aliquots of a serum preparation called "run control" containing low levels (1.4 ng/ml) of hepatitis B surface antigen (HBsAg) were tested by four American Red Cross Blood Services regions using a commercial test based on enzyme-linked immunosorbent assay (EIA). The run control was tested a total of 424 and 892 times by procedures A and C, respectively, as recommended by the manufacturer (Abbott Laboratories, North Chicago, IL) of the EIA test kit. Results of all the tests were analyzed and showed that the run control was stable and reliable under field conditions. Illustrative examples of different approaches for the use of the run control in monitoring quality control of HBsAg testing are discussed.

Blood Banks↗
PubMedDate not supplied

Life after brain injury.

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Adaptation, Psychological↗
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Relative values.

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Communication↗
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Hidden loss.

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Abortion, Spontaneous↗
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Avulsion of the quadriceps tendons in a patient with an unusual deforming arthritis and varied skin lesions.

Spontaneous avulsion of both quadriceps tendons occurred in a young woman who had been treated with corticosteroids for progressive severely deforming seronegative arthritis and recurring skin lesions clinically and histologically suggestive of cutaneous vasculitis and pyoderma gangrenosum. We postulate that recurrent minor trauma to tendons previously damaged by vasculitis and inhibition of tendon repair by oral corticosteroids were predisposing factors to the bilateral tendon avulsions.

Adrenal Cortex Hormones↗
PubMedDate not supplied

On home ground.

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Adaptation, Psychological↗