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Biomedical subjects

S Weinberg

Publications and source records attributed to S Weinberg.

At least 91 records · Page 5Linked to original sources
PubMed1982

Severe sclerosis of the long bodies in sickle cell anemia.

In reviewing the radiographs of 102 patients with known sickle cell anemia, a 7% incidence (seven patients) of severe long-bone sclerosis was found. Of the affected patients 50% had homozygous sickle cell (SS) disease and 50% had sickle cell-hemoglobin C (SC) or S-thalassemia disease. No distinguishing radiographic features were found between these two groups. Those patients with SS disease and long-bone sclerosis were younger, had lower hemoglobin levels, and many more hospital admissions than those with SC or S-thalassemia disease and long-bone sclerosis. A review of the medical charts of these osteosclerotic patients with SS disease showed a probable positive correlation between infarctive episodes and hospital admissions in these patients. Therefore, patients with SS disease and severe long-bone sclerosis are seen much more frequently by the radiologist than those with SC or S-thalassemia and long-bone changes. These observations help negate any impression that severe long-bone sclerosis occurs frequently in and has a predilection for patients with homozygous SS disease.

Adolescent↗
PubMed1979

Congenital unilateral ichthyosis in a newborn.

Ichthyosiform erythroderma is a rare phenomenon occurring in about 1/300,000 live births. Congenital unilateral ichthyosis, described in this case report, is a clinical variant of ichthyosis. Only five previous cases have been reported. In the patient described in this report, superimposed infection of the affected skin developed. Her immunologic system was intact. She manifested failure to thrive, in spite of an adequate caloric intake, and markedly delayed psychomotor development. This patient also demonstrated absorption from the affected dermis of topically applied urea hydrophilic base ointment. She died before her first birthday.

Female↗
PubMed1976

Duration of hospitalization in "uncomplicated completed acute myocardial infarction". An Ad Hoc Committee review.

The clinical and laboratory findings diagnostic of acute myocardial infarction include at least two of the following: (1) a history of pain consistent with myocardial ischemia, (2) electorcardiographic findings consistent with infarction, and (3) a rise in the serum level of specific cardiac enzymes. By the 4th or 5th day of illness, specific criteria can be applied to assign certain patients to a subset with "uncomplicated completed acute myocardial infarction." These criteria include the absence of evidence of (1) continuing cardiac ischemia, (2) left ventricular failure, (3) shock, (4) important cardiac arrhythmias, (5) conduction disturbances, and (6) other serious illnesses in patients with an established acute myocardial infarction. In terms of prognosis and management, patients in this subset should be regarded as substantively different from patients in other subsets. They should respond favorably to short periods of immobilization and hospitalization than those generally used. They may remain at bed rest (modified in regard to sitting and the use of a commode) for 4 days. Subsequently, mobilization with a program of progressive activity over the ensuing 5 to 10 days should reduce the duration of hospitalization to less than the current average of 17.5 to 20.8 days for patients with acute myocardial infarction. Nine to 14 days should suffice in most instances. Current and future trials may indicate that still earlier mobilization and shorter hospitalization periods can be applied to certain patient groups, but the evidence on this point is incomplete. For the individual patient, many factors will determine the optimal duration of bed rest and hospital stay. The patient's physician must consider the therapeutic benefits that may attend earlier mobilization and shorter hospitalization while weighing potential disadvantages. When the responsible physician does not regularly care for the patient, consultation with an experienced cardiologist is desirable. Patients whose condition is classified as "uncomplicated" may manifest deterioration during their illness and require assignment to a subset with a different prognosis and requiring different forms of treatment. For patients with uncomplicated acute myocardial infarction, as well as those in other subsets, absolute rules for therapy are unwise and application of broader principles by the alert physician is more likely to be beneficial.

Arrhythmias, Cardiac↗