Biomedical subjects

S Wang

Publications and source records attributed to S Wang.

At least 307 records · Page 17Linked to original sources

PubMed2001

[Analysis of inductive factors, diagnosis and treatment of 21 cases with pregnancy accompanied with pulmonary edema].

OBJECTIVE: To investigate the inductive factors, the prevention and treatment methods of pulmonary edema during pregnancy. METHODS: The clinical materials of 21 cases of pregnancy with pulmonary edema treated in our hospital from Jan. 1985 to Jan. 2000 were analysed retrospectively. RESULTS: Among 21 patients, 26 pulmonary edema attacked, 9 of them had upper have respiratory diseases, thirteen cases caused by improper infusion. Fourteen cases were well controlled quickly with antiplasm nifedipine, myocardial strength and diuretics. If the symptoms could not be controlled properly, vasodilators were applicated. We had 16 cesarean section under epidural anaesthesia, one vaginal birth, and the other one birth by forceps. CONCLUSIONS: Pulmonary edema in pregnancy usually followed with acute heart failure caused by sever pregnancy induced hypertension. We should pay more attention to the indications of it. During treatment, we should give vasodilators properly, so as to prevent pulmonary edema.

Adult↗

PubMed2001

[An epidemiological study on the factors influencing length of hospitalization for inpatients of burns].

OBJECTIVE: To provide evidence for intervention on secondary prevention of burns through studying the factors influencing the length of hospitalization on inpatients of burns. METHODS: Seven hundred and ninety burnt patients with cluster sampling, combined analyzing with Cox regression and factor analysis. RESULTS: The influential factors on the length of hospitalization in inpatients with burns included a) how did the patients come to the hospital (X3), b) total body surface area involved (X4), c) depth of burns (X5), and d) the time before hospitalization after burnt (X6). The Cox proportional hazard model used was h(t)/h0(t) = e(-0.193 3F1 -0.617 6F2 -0.118 0F3), and the conversion model between factors Fi and original variates were F1 = -0.132X3 - 0.009X4 + 0.655X5 + 0.583X6, F2 = 0.019X3 + 0.875X4 + 0.257X5 - 0.294X6, F3 = 1.010X3 + 0.025X4 - 0.176X5 + 0.030X6. Data showed that the burnt patients had longer hospitalization time when the burns were deep, larger body surface area involved, and with longer delay before getting to the hospitals, where as the patients got cured faster when taken to the hospital by ambulances. CONCLUSION: One of the major prognostic factors of burns was to treat the patients in time. Secondary prevention of burns must be reinforced.

Adolescent↗

PubMed2001

17 beta-Estradiol inhibits carotid sinus baroreceptor activity in anesthetized male rats.

AIM: To study the effect of 17beta-estradiol (E2) on carotid baroreceptor activity (CBA). METHODS: The functional curve of carotid baroreceptor (FCCB) was constructed and the functional parameters of carotid baroreceptor were measured by recording sinus nerve afferent discharge in anesthetized male rats with perfused isolated carotid sinus. RESULTS: E2 3, 10, and 30 micromol/L shifted FCCB to the right and downward, with a marked decrease in peak slope (PS) and peak integral value of carotid sinus nerve discharge (PIV) in a concentration-dependent manner, indicating the inhibitory effect of E2 on CBA. Pretreatment with tamoxifen (TAM) 10 micromol/L, an inhibitor of estrogen receptor, did not block the effect of E2 on CBA. Preperfusion with L-NAME 100 micromol/L, an inhibitor of NO synthase, could completely abolish the effect of E2 on CBA. NO donor SIN-1 10 micromol/L could potentiate the inhibitory effect of E2. CONCLUSION: E2 inhibits CBA via endothelial NO release.

Anesthesia↗

PubMed2001

Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers.

UNLABELLED: Elevated levels of choline (trimethyl-2-hydroxyethylammonium) and choline kinase (CK) activity in neoplasms have motivated the development of positron-labeled choline analogs for noninvasive detection of cancer using PET. The aim of this study was to further evaluate [(18)F]fluorocholine (fluoromethyl-dimethyl-2-hydroxyethylammonium [FCH]) as an oncologic probe in comparison with several other closely related molecules. METHODS: FCH, [(18)F]fluoromethyl-methylethyl-2-hydroxyethylammonium (FMEC), [(18)F]fluoroethyl-dimethyl-2-hydroxyethylammonium (FEC), and [(18)F]fluoropropyl-dimethyl-2-hydroxyethylammonium (FPC) were synthesized through [(18)F]fluoroalkylation reactions. In vitro phosphorylation rates of the (18)F-labeled choline analogs and [methyl-(14)C]choline (CH) were studied using yeast CK. Several choline radiotracers were also evaluated in cultured PC-3 human prostate cancer cells. Data on chemical stability, radiation dosimetry, and toxicity of FCH were obtained. PET studies with FCH were performed on a patient with prostate cancer and a patient with a brain tumor. RESULTS: FCH and FMEC revealed in vitro phosphorylation by CK that was similar to that of choline, whereas rates of phosphorylation of FEC and FPC were 30% (P < 0.01) and 60% (P < 0.01) lower, respectively. Accumulations of FCH, CH, and FPC in cultured PC-3 cancer cells were comparable, whereas uptake of FEC was approximately one fifth that of FCH. Dosimetry estimates using FCH biodistribution data in mice indicated that the kidneys are radiation-dose-critical organs for FCH. PET images of a patient with recurrent prostate cancer showed uptake of FCH in the prostatic bed and in metastases to lymph nodes. FCH PET showed uptake in malignancies in a patient with metastatic breast cancer. PET revealed FCH uptake in biopsy-proven recurrent brain tumor with little confounding uptake by normal brain tissues. CONCLUSION: The fluoromethyl choline analog FCH may serve as a probe of choline uptake and phosphorylation in cancer cells, whereas fluoroethyl (FEC) and fluoropropyl (FPC) analogs appear to have relatively poorer biologic compatibility. Preliminary PET studies on patients with prostate cancer and with breast cancer and brain tumor support further studies to evaluate the usefulness of FCH as an oncologic probe.

Adult↗

PubMed2001

[State of soil available sulphur and its requirement along Huaihe River region].

This paper investigated the available S contents of yellow cinnamon soil, fluvisol, shajiang black soil and paddy soil, which were developed from loessial ancient-river alluyium, recent loess-flooding deposit, and Xiashu loess. The input and output, and the abundance and deficiency of soil available S were studied in combination with the mode of land utilization and fertization, and the soil demands of S was predicted. The results showed that the content of soil available S was decreased in the order of paddy soil > shajiang black soil > yellow cinnamon soil > fluvisol, and there was more S in irrigated land than in dry field in case of different land utilization. From the viewpoint of parent material, the deficiency frequency of soil available S was in the order of loessial ancient-river alluvium > Xiashu loess > recent loess-flooding deposit, and the potential deficiency frequency of S was loessial ancient-river alluvium > recent loess-flooding > Xiashu loess. As for soil type, the deficiency frequency of soil available S was in the order of deposit shajiang black soil > yellow cinnamon soil > fluvisol > paddy soil, and the potential deficiency frequency of S was paddy soil > fluvisol > shajiang black soil > yellow cinnamon soil. Shajiang black soil had the largest area of lacking available S, which amounted to 7.0 x 10(4) hm2, yellow cinnamon soil had an area of 2.0 x 10(4) hm2, and fluvisol was 6000 hm2. The total area of lacking S was 9.6 x 10(4) hm2, accounted for 25.06% of total cultivated area. The total area of potentially lacking S was 1.6 x 10(5) hm2, accounted for 42.04% of the total. According to the current available S content in soils and the S demands for high yielding crops, the S demands of 3.8 x 10(5) hm2 farmland in three counties and one district of Bengbu was about 3.0 x 10(6) kg and 1.2 x 10(6) kg in the recent and far future, respectively.

Fertilizers↗

PubMed2001

[Influence of different clipping intensity and R/FR ratio in light radiation on tillering of weeping lovegrass].

Pot experiment with weeping lovegrass was conducted laboratory in the Department of Rangeland, Wildlife and Fisheries Management, Texas Tech University in 1996. The plants grown in green house were used to study the effect of different clipping intensities on tillering, and those grown in laboratory were used to study the interaction between different R/FR(red/farred) ratio of the light reaching to the lower strata of the canopy and different clipping intensities on tillering. The results show that increasing clipping intensity decreased the net gain tillers, bt R/FR ratio had no significant effect on tillering, except no clipping treatment. The compensatory growth effect of tillering did not existed at all clipping intensities, but the elongation speed of young leaves quickened with clipping intensities. It is suggested that suitable utilization, intensified utilization and no utilization were all not beneficial to the growth and development of weeping lovegrass.

Light↗

PubMed2001

[Distribution characteristics and seasonal dynamics of phosphorus and potassium in wetland ecosystem in the Sanjiang Plain].

From May to October in 1997, the plant, soil and logging water in the wetlands were sampled monthly, and their P and K concentrations were measured. With the method of one-factor non-linear regression analysis, the seasonal dynamics of P and K in two types of wetland i.e., in Carex lasiocarpa-Glyceria spiculosa wetland and in Deyeuxia angustifolia wetland were studied. The concentrations of P and K varied with different species of wetland plant and different organs of the same plant species. But their common property was that the concentration of K was higher than that of P, which shows that the mire-wetland plants had the property of enriching K element. The concentrations of P and K had an obvious seasonal dynamics in plant, soil and logging water, but the patterns were not the same. Some simulation models were obtained, which could be used to forecast the seasonal dynamics of P and K contents.

China↗

PubMed2001

[Study on the effects of leptin on puberty development in children].

OBJECTIVE: To study the effects of leptin on puberty development in children. METHODS: Three hundred obese and 300 healthy children without taking any medication or having evidence of endocrine or metabolic diseases were studied. Their ages of first spermatorrhea and menarche were surveyed, and blood levels of leptin, sex hormones, growth hormone (GH) and insulin (INS) were measured. RESULTS: With increased of age, blood levels of leptin appeared from low to high and from high to low again in the boys, with (1.04 +/- 0.21) nmol/L to (1.20 +/- 0.27) nmol/L and to (0.66 +/- 0.10) nmol/L in the obese group, and with (0.31 +/- 0.06) nmol/L to (0.45 +/- 0.10) nmol/L and to (0.19 +/- 0.04) nmol/L in the control group. While blood level of leptin appeared an increasing trend in girls, with (0.89 +/- 0.15) nmol/L to (1.39 +/- 0.23) nmol/L in the obese group, and (0.46 +/- 0.08) nmol/L to (0.88 +/- 0.18) nmol/L in the control group. Levels of sex hormones also appeared an increasing trend in the all groups. Levels of GH showed an abrupt increased at certain ages, different in boys from girls (14-15 years of age in boys and 13-14 in girls). In the all ages, serum levels of leptin and INS were higher in the obese group than those in the control group, while the level of GH was lower in the obese group than that in the control group. Serum level of leptin was higher in the obese group of both boys and girls than that in the control group, with (0.71 +/- 0.17) nmol/L and (0.30 +/- 0.04) nmol/L and (1.11 +/- 0.21) nmol/L and (0.70 +/- 0.18) nmol/L, respectively. Ages at first spermatorrhea and menarche were much earlier in the obese children than those in the controls, with (12.5 +/- 1.2) and (13.2 +/- 1.2) years of age in boys and (11.6 +/- 0.8) and (12.8 +/- 0.9) in the girls, respectively. Blood levels of leptin was higher in the girls than that in the boys. Age at menarche and earlier in the girls than that of first spermatorrhea in the boys. Blood level of testosterone correlated inversely with that of leptin in boys, while that of estradiol correlated with that of leptin in girls. Level of GH correlated inversely with that of leptin in boys and correlated with that in girls. Level of INS correlated with that of leptin in the control girls. CONCLUSIONS: Leptin might have an effect on initiation of puberty in children, possibly with more importance in girls than in boys. The gender difference in the degree of correlations between levels of leptin and GH may cause their difference in the ages at sudden growth in boys and girls. The gender difference in the degree of correlation between levels of leptin and sex hormone may cause their difference in the ages at first spermatorrhea and menarche in both boys and girls.

Adolescent↗

PubMed2001

[Effect of soybean protein and high calcium intake on the concentration of serum lipids in hypercholesterolemic rats].

OBJECTIVE: To investigate the effects of dietary soybean protein or/and high calcium intake on the concentration of serum total cholesterol (TC) and serum lipids in hypercholesterolemic rats. METHODS: Following 14 days of inducing the hypercholesterolemia model successfully, 24 female rats were fed 4 experimental diets contained 20% of protein each from either casein or soybean protein and either a normal or high concentration of calcium (0.59% and 1.12%) in a 2 x 2 factorial design. RESULTS: After the experimental diets had been fed for 21 days, TC was (10.56 +/- 2.74, 7.99 +/- 2.19, 5.48 +/- 0.51 and 6.81 +/- 0.98) mmol/L in the rats fed diets containing casein and normal concentration of calcium, casein and high concentration of calcium, soybean, protein and normal concentration of calcium, and soybean protein and high concentration of calcium, respectively. According, Serum apolipoprotein B100(ApoB100) was (0.46 +/- 0.14, 0.31 +/- 0.12, 0.17 +/- 0.07, and 0.21 +/- 0.05) g/L, respectively. Comparing with the rats in casein group, the TC and ApoB100 of the rats in other 3 groups were significantly low (P < 0.05). Whereas, the changes of TG and HDL-C were not significant in these rats. CONCLUSIONS: Dietary soybean protein or/and high calcium intake lower TC in hypercholesterolemic rats and there is an interactive effect of these two dietary factors on lowering TC. Further researches are needed for explaining the possible mechanism of soybean protein and high calcium intake on lowering TC.

Animals↗

PubMed2001

[Experimental study of bacteriostatic activity of Chinese herbal medicines on primary cariogenic bacteria in vitro].

OBJECTIVE: To screen some Chinese herbal medicines for their inhibitory activity on cariogenic bacteria, and investigate their active ingredients, and measure their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC). METHODS: Active components were isolated from every tested Chinese herbal medicine by means of aqueous extraction and ethanolic extraction. Berberine was purified from Coptis chinensis Fra. Disk agar diffusion method was employed in screening herbs with inhibiting effect on cariogenic bacteria. MIC and MBC were determined by broth dilution method. RESULTS: Against Streptococcus mutans Ingbritt, MBCs of Magnolia officinalis ethanolic extract, Berberine, Coptis chinensis Fra aqueous extract and Coptis chinensis Fra ethanolic extract were 0.488, 0.625, 7.800 and 1.950 g/L respectively. Against Streptococcus sobrinus 6715, MBCs of Magnolia extract, Coptis chinensis Fra ethanolic extract, Rhus chinensis Mill ethanolic extract and Phellodendron chinen ethanolic extract were 0.488, 0.625, 1.950, 3.900, 3.900 and 3.900 g/L respectively. Against Actinomyces viscosus ATCC 19246, MBCs of Berberine, Coptis chinensis Fra aqueous extract, Coptis chinensis Fra ethanolic extract, Rheum palmatum L aqueous extract and Rheum palmatum L ethanolic extract were 1.250, 3.900, 3.900, 15.600 and 31.250 g/L respectively. CONCLUSIONS: Magnolia officinalis, Coptis chinensis Fran, Rheum palmatum L aqueous extracts exhibit strong inhibition on cariogenic bacteria. Magnolia officinalis ethanolic extract has the strongest bactericidal effects on Streptococcus mutans and Streptococcus sobrinus.

Cariogenic Agents↗

PubMed2001

[Relationship between the expression of connexin 43 and bystander effect of suicide gene therapy in ovarian cancer].

OBJECTIVE: To explore the relationship of connexin 43(Cx43) and bystander effect in ovarian tumor cells in herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) gene therapy in vitro, and to investigate the effection of all-trans retinoic acid (RA) on expression of Cx43 and bystander effect. METHODS: Cx43 expression was examined with flowcyto-metry, Western Blot, and immunofluorescence in two ovarian tumor cells OVCAR3, CAOV3 before and after RA treatment. Bystander effect was determined by the cells growth inhibitory rate with methyl thiazolyl tetrazolium. RESULTS: Following exposure to ganciclovir, there was much greater bystander killing in OVCAR3 than in CAOV3 (P < 0.05). The expression of Cx43 was detected in OVCAR3 with flowcytometry and Wstern Blot, but it could not be detected in CAOV3. The expression of Cx43 in both cell lines could be induced by RA. Immunofluorescence staining showed that OVCAR3 Cx43 protein is located in membrane surface, whereas CAOV3 is in cytoplasm. RA could not change the location of Cx43 protein in both cell lines. CONCLUSIONS: There is relationship between Cx43 expression and HSV-TK/GCV bystander effect. HSV-TK/GCV bystander effect can be inhanced by RA in ovarian cancer.

Antineoplastic Agents↗

PubMed2001

[Analysis of loss of heterozygosity on 19p in primary gastric cancer].

OBJECTIVE: To investigate the loss of heterozygosity (LOH) frequency of microsatellite loci in primary gastric cancer samples and locate the deleted regions on 19p in which might exist human gastric cancer related genes. METHODS: The LOH of microsatellite loci on chromosome 19p was analyzed using PCR-SSLP-silver stain method in 43 primary gastric cancers and their paired normal tissues. RESULTS: In 43 primary gastric tumors, LOH was detected on the site for D19S424(29.63%), D19S216(11.53%), D19S406 (33.33%), D19S413(8.57%), D19S221(13.15%), D19S226(8.00%), D19S411(6.45%), D19S883(6.89%), and D19S886(10.71%), microsatellite instability (MSI) was found at the same time at locus D19S886 (17.85%). CONCLUSION: The most common LOH occurrence at D19S406 and D19S424 might imply the existence of the potential genes related to the tumorigenesis of gastric cancer in these loci.

Chromosome Mapping↗

PubMed2001

[The relationship between maternal infection with human parvovirus B19 and fetal death and congenital malformation].

OBJECTIVE: To study the relationship between matanal infection with human parvovirus B19 and fetal death and congenital malformation. METHOD: B19-DNA was detected by Polymerase Chain Reaction (PCR) in blood samples from 335 pregnant women. The pregnant outcomes were followed. RESULTS: In 335 pregnant women, 67 cases were B19-DNA positive and 268 cases were B19-DNA regative. There were four fetal deaths and one anencephalus in B19-DNA positive group. There was no fetal deaths or congenital malformation in B19-DNA negative group. The difference is significant (P < 0.05). CONCLUSIONS: Maternal infection with human parvovirus B19 may contribute to fetal death and congenital malformation.

Congenital Abnormalities↗

PubMed2001

bcl 10 gene mutation in hepatocellular carcinoma.

OBJECTIVE: To detect the mutation frequency of the bcl 10 gene in the early and advanced stages of hepatocellular carcinoma (HCC). METHODS: Genome DNA samples were extracted from 46 cases of fresh HCC tumor tissues and their non-tumor adjacent tissues. Polymerase chain reaction-single strand conformation polymorphism method was used to detect point mutations of the three exons of the bcl 10 gene. For each individual exon, six random samples from those showing abnormal DNA bands were sequenced to verify those mutations. The relationship between serum alpha-fetoprotein (AFP) level and bcl 10 mutation, between the tumor size and bcl 10 mutation was also analyzed. RESULTS: Among the 46 samples, 26 cases (56.5%) were found to have mutations in exon 1, 5 out of the 6 cases were shown to have 5744 C-->G mutation by sequencing; 25 cases (54.3%) were found to have mutations in exon 2, 4 out of the 6 cases were shown to have 11,311 T deletion mutation by sequencing. Twenty-one cases (45.7%) were found to have mutations in exon 3, all of the 6 cases selected for sequencing were shown to have 14,116 C-->T mutation. Statistical analysis showed that neither serum alpha-fetoprotein level nor the size of hepatocellular carcinoma has a significant relationship with bcl 10 mutation. CONCLUSION: The bcl 10 gene has a high mutation frequency in liver cancer.

Adaptor Proteins, Signal Transducing↗

PubMed2001

Surgical treatment of 52 patients with congenital coronary artery fistulas.

OBJECTIVE: To evaluate the outcome of surgical treatment for congenital coronary artery fistulas (CAF) in 52 patients seen between May 1988 and July 1999. METHODS: Fifty-two patients ranging in age from 9 months 58 years (mean 15.7 +/- 16.4 years) were studied. Thirty-six patients had no other cardiac defects, 9 of those patients were more than 20 years old and presented with symptoms. Only one of 36 patients less than 20 years old had clinical findings before surgery. Sixteen patients had associated cardiac lesions. The site of fistula origin was the right coronary artery in 37 patients (71.2%), and the left coronary artery in 15 patients (28.8%). The sites of CAF drainage were the right ventricle, right atrium, left ventricle, left atrium and pulmonary artery in 22 (42.3%), 16 (30.8%), 6 (11.5%), 3 (5.8%), and 5 (9.6%) patients, respectively. The mean diameter of the fistula in 43 patients with single ostium was 7.34 +/- 4.12 mm. RESULTS: Cardiopulmonary bypass was used in all patients and no patient died. An arteriotomy was made on the anomalous coronary artery and the proximal opening of a fistula was closed within the vessel in 10 patients. Closure of the distal opening of a fistula draining into a cardiac chamber or pulmonary artery was performed in 26 patients. In 16 patients, both the proximal and distal opening were closed. Two and 3 distal opening of a fistula were found in 6 and 3 patients, respectively. No residual shunt was found before patients were discharged from the hospital. Forty patients were followed up for a mean period of 3.14 +/- 1.84 years. The remaining 12 patients could not be contacted during follow-up. No clinical symptoms were found in those patients during follow-up but one patient still presented with ST-T change. CONCLUSION: Early and properly surgical management is safe and effective for congenital coronary fistula.

Adolescent↗

PubMed2001

Cordotomy for bilateral cord abductal paralysis.

OBJECTIVE: To investigate the clinical effects of cordotomy on bilateral cord abductal paralysis. METHODS: With unilateral cordotomy, we treated 4 patients with bilateral cord paralysis whose glottis size was about 2.0 mm to 2.5 mm. They were followed up for over one year. RESULTS: One week after surgery, the tracheotomy tubes of all 4 patients were plugged and no dyspnea occurred during rest and mild action. Their voices were more hoarse than before surgery. After 3 months, the tracheotomy tubes were successfully decannulated, and in the following one year, their respiration was normal and then speech was clear, although their voices were still a little hoarse. CONCLUSION: We suggest that cordotomy be one option in the treatment of bilateral cord abductal paralysis.

Adult↗

PubMed2001

Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury.

OBJECTIVE: To observe the effect of aloe-emodin on the expression of proliferating cell nuclear antigen (PCNA) in smooth muscle cells (SMCs) after arterial injury and study the molecular mechanism of inhibition of aloe-emodin on SMC proliferation. METHODS: Deendothelialization was performed at the abdominal aorta in Japanese white rabbits using a 3F Fogarty arterial embolectomy catheter. 48 hours later, the medium of abdominal aorta was isolated and primary SMCs culture was performed. Cells were synchronized to G0 by serum starvation, then aloe-emodin at a concentration of 20 micrograms/ml was added to the culture medium containing 10% [v/v] fetal calf serum. Vehicle was also added to the medium as a control. After 18 hours, the expression of PCNA at the level of mRNA and protein were examined using techniques of RT/PCR, Western blotting and inmmunocytochemistry respectively. RESULTS: Compared with the control group, the expression of PCNA mRNA and protein was prominently decreased after addition of aloe-emodin. CONCLUSION: The inhibition of aloe-emodin on SMCs proliferation may be caused by inhibiting the expression of the PCNA gene.

Animals↗

PubMed2001

Infections caused by Flavimonas oryzihabitans.

OBJECTIVE: To assess retrospectively the clinical characteristics and cell immune function of infections caused by Flavimonas oryzihabitans (F. oryzihabitans). METHODS: We indentified 11 cases of F. oryzihabitans positive cultures from all microbial cultures collected in our hospital from November 1994 to December 1998. Relevant clinical information was collected, including demographic data, underlying disease, and clinical manifestations of the F. oryzihabitans infections. Minimal inhibitory concentrations (MICs) of 15 antimicrobial agents against the 11 F. oryzihabitans isolates were determined. Cell immune function tests were determined by flow cytometry including T lymphocyte subsets (CD3, CD4, CD8 and ratio CD4/CD8) and NK cells (CD16 + 56) from peripheral blood. RESULTS: Six of these patients with infections caused by F. oryzihabitans were male, 5 were female and the mean age was 47.64 years (range, 5 to 69 years). All but 1 patients had severe underlying diseases. 9 (81.8%) of these patients developed infection while hospitalization and 2 (18.2%) before hospitalization (Cases 2 and 5). 8 (72.7%) of these patients manifested primary F. oryzihabitans bacteremia and one each (9.1%) had pleurisy, soft tissue infection and peritonitis. All these isolates were susceptible to amikacin, gentamicin and ciprofloxacin, but resistance to cefazolin, nitrofurantoin, penicillin and piperacillin. CD3, CD4, CD4/CD8 and CD16 + 56 value (mean +/- s) of these patients were significantly lower than normal values (P < 0.01). The mean time of body temperature fell < or = 37 degrees C after antibiotic treatment in these patients was 3.5 days (range, 1 to 6 days). All clinical symptom caused F. oryzihabitans after antibiotic treatment disappeared and all patients recovered. CONCLUSIONS: Infections caused by F. oryzihabitans was very few clinically, and relative to underlying diseases and the presence of foreign material. Immune function abnormality was among mostly factor for the F. oryzihabitans infections.

Adult↗